Patents by Inventor Wenjun Ouyang

Wenjun Ouyang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Novel PRO1199 gene disruptions, and methods relating thereto
    Publication number: 20120174239
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: October 27, 2011
    Publication date: July 5, 2012
    Inventors: Stephen Jay Anderson, Jane Brennan, Frederic J. de Sauvage, Zhiyong Ding, Joel Edwards, Nelda A. Fikes, Wenhu Huang, Wenjun Ouyang, Carolina Rangel, Mamta Sangha, Zheng-Zheng Shi, Mary Jean Sparks, Joseph Trackey, Melissa Vetter, Ching-Yun Wang, Jessica Woodings
  • Anti-PRO87299 Antibodies
    Publication number: 20120171208
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
    Type: Application
    Filed: March 2, 2012
    Publication date: July 5, 2012
    Applicant: Genentech, Inc.
    Inventors: Hilary Clark, Daniel L. Eaton, Bernd Wranik, Wenjun Ouyang, Lino Gonzalez, Austin L. Gurney, Kelly Loyet
  • METHODS FOR TREATMENT OF MICROBIAL DISORDERS
    Publication number: 20110280828
    Abstract: The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
    Type: Application
    Filed: May 20, 2011
    Publication date: November 17, 2011
    Inventors: Alexander R. ABBAS, Nico P. Ghilardi, Zora Modrusan, Dimitry M. Danilenko, Frederic J. De Sauvage, Wenjun Ouyang, Patricia A. Valdez, Yan Zheng
  • IL-17A/F Heterologous Polypeptides and Therapeutic Uses Thereof
    Publication number: 20110256126
    Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: March 2, 2011
    Publication date: October 20, 2011
    Inventors: David P. Arnott, Mercedes Z. Balazs, Nico Ghilardi, Austin L. Gurney, Philip E. Haas, Sarah Hymowitz, James M. Lee, Wenjun Ouyang, Melissa A. Starovasnik, Yan Wu
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20110245090
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: March 11, 2011
    Publication date: October 6, 2011
    Inventors: Alexander Abbas, Hilary Clark, Wenjun Ouyang, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • Anti-PRO87299 antibodies
    Patent number: 7863422
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
    Type: Grant
    Filed: July 25, 2008
    Date of Patent: January 4, 2011
    Assignee: Genentech, Inc.
    Inventors: Hilary Clark, Daniel L. Eaton, Bernd Wranik, Wenjun Ouyang, Lino Gonzalez, Austin L. Gurney, Kelly Loyet
  • COMPOSITIONS AND METHODS FOR TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH CYTOKINE SIGNALING
    Publication number: 20100316596
    Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
    Type: Application
    Filed: April 13, 2010
    Publication date: December 16, 2010
    Inventors: Yvonne M. Chen, Anan Chuntharapai, Dimitry Danilenko, Wenjun Ouyang, Susan Sa, Patricia Valdez, Terence Wong, Jianfeng Wu, Yan Zheng
  • TREATMENT OF INSULIN-RESISTANT DISORDERS
    Publication number: 20100266595
    Abstract: The invention concerns the treatment of insulin-resistant disorders. In particular, the invention concerns the treatment of insulin-resistant disorders by administration of IL-17, such as IL-17A and/or IL-17F antagonists, such as anti-IL-17A and/or IL-17F and/or IL-17Rc antibodies, or antibody fragments.
    Type: Application
    Filed: March 30, 2010
    Publication date: October 21, 2010
    Inventors: Ganesh A. Kolumam, Yan Hu, Wenjun Ouyang
  • Compositions and methods for the treatment of diseases and disorders associated with cytokine signaling
    Patent number: 7737259
    Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
    Type: Grant
    Filed: November 30, 2006
    Date of Patent: June 15, 2010
    Assignee: Genentech, Inc.
    Inventors: Yvonne M. Chen, Anan Chuntharapai, Dimitry Danilenko, Wenjun Ouyang, Susan Sa, Patricia Valdez, Terence Wong, Jianfeng Wu, Yan Zheng
  • CROSS-REACTIVE AND BISPECIFIC ANTI-IL-17A/F ANTIBODIES
    Publication number: 20100055103
    Abstract: The present invention relates generally to antibodies cross-reactive with IL-17A and IL-17F, and bispecific anti-IL-17A/F and their uses.
    Type: Application
    Filed: August 26, 2009
    Publication date: March 4, 2010
    Inventors: YONGMEI CHEN, YAN (HELEN) HU, WENJUN OUYANG, SCOTT STAWICKI, YAN WU
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20100034817
    Abstract: The present invention relates to compositions containing novel proteins and methods of using those compositions for the diagnosis and treatment of immune related diseases.
    Type: Application
    Filed: October 7, 2009
    Publication date: February 11, 2010
    Inventors: Alexander Abbas, Hilary Clark, Wenjun Ouyang, P. Mickey Williams, William I. Wood, Thomas D. Wu
  • Compositions and methods for treatment of microbial disorders
    Publication number: 20090202475
    Abstract: The present invention relates to compositions and methods for treatment of microbial disorder by modulation of the host immune response. More particularly, the present invention relates to compositions that mediate an anti-microbial immune response, and methods of treating a microbial infection using such compositions.
    Type: Application
    Filed: November 7, 2008
    Publication date: August 13, 2009
    Applicant: Genentech, Inc.
    Inventors: Alexander R. Abbas, Nico P. Ghilardi, Zora Modrusan, Dimitry M. Danilenko, Frederic J. De Sauvage, Wenjun Ouyang, Patricia A. Valdez, Yan Zheng
  • NOVEL COMPOSITIONS AND METHODS FOR THE TREATMENT OF IMMUNE RELATED DISEASES
    Publication number: 20090175855
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
    Type: Application
    Filed: March 14, 2007
    Publication date: July 9, 2009
    Inventors: Hilary Clark, Daniel L. Eaton, Jill Fenaux, Lino Gonzalez, Austin L. Gurney, Kelly M. Loyet, Wenjun Ouyang, Bernd Wranik
  • ANTI-PRO87299 ANTIBODIES
    Publication number: 20090081229
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease
    Type: Application
    Filed: November 12, 2008
    Publication date: March 26, 2009
    Applicant: GENENTECH, INC.
    Inventors: HILARY CLARK, DANIEL L. EATON, BERND WRANIK, WENJUN OUYANG, LINO GONZALEZ, AUSTIN L. GURNEY, KELLY LOYET
  • ANTI-PRO87299 ANTIBODIES
    Publication number: 20090022713
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease
    Type: Application
    Filed: July 25, 2008
    Publication date: January 22, 2009
    Applicant: Genentech, Inc.
    Inventors: Hilary Clark, Daniel L. Eaton, Bernd Wranik, Wenjun Ouyang, Lino Gonzalez, Austin L. Gurney, Kelly Loyet
  • Anti-PRO87299 antibodies
    Patent number: 7479544
    Abstract: The present invention relates to compositions containing a novel protein and methods of using those compositions for the diagnosis and treatment of immune related disease.
    Type: Grant
    Filed: November 12, 2004
    Date of Patent: January 20, 2009
    Assignee: Genentech Inc.
    Inventors: Hilary Clark, Daniel L. Eaton, Bernd Wranik, Wenjun Ouyang, Lino Gonzalez, Austin L. Gurney, Kelly Loyet
  • Novel Gene Disruptions, Compositions and Methods Relating Thereto
    Publication number: 20070292438
    Abstract: The present invention relates to transgenic animals, as well as compositions and methods relating to the characterization of gene function. Specifically, the present invention provides transgenic mice comprising disruptions in PRO224, PRO9783, PRO1108, PRO34000, PRO240, PRO943, hu A33, PRO230, PRO178, PRO1199, PRO4333, PRO1336, PRO19598, PRO1083, hu TRPM2 or PRO1801 genes. Such in vivo studies and characterizations may provide valuable identification and discovery of therapeutics and/or treatments useful in the prevention, amelioration or correction of diseases or dysfunctions associated with gene disruptions such as neurological disorders; cardiovascular, endothelial or angiogenic disorders; eye abnormalities; immunological disorders; oncological disorders; bone metabolic abnormalities or disorders; lipid metabolic disorders; or developmental abnormalities.
    Type: Application
    Filed: December 13, 2004
    Publication date: December 20, 2007
    Inventors: Stephen Anderson, Jane Brennan, Frederic de Sauvage, Zhiyong Ding, Joel Edwards, Nelda Fikes, Wenhu Huang, Wenjun Ouyang, Carolina Rangel, Mamta Sangha, Zheng-Zheng Shi, Mary Sparks, Joseph Trackey, Melissa Vetter, Ching-Yun Wang, Jessica Woodings
  • COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASES AND DISORDERS ASSOCIATED WITH CYTOKINE SIGNALING
    Publication number: 20070212356
    Abstract: Compositions and methods are provided for the diagnosis and treatment of inflammation and autoimmune disorders, such as psoriasis. Compositions and methods for modulating IL-23 or IL-22 signaling are provided.
    Type: Application
    Filed: November 30, 2006
    Publication date: September 13, 2007
    Inventors: Yvonne Chen, Anan Chuntharapai, Dimitry Danilenko, Wenjun Ouyang, Susan Sa, Patricia Valdez, Terence Wong, Jianfeng Wu, Yan Zheng
  • Compositions and methods for the treatment of immune related diseases
    Publication number: 20070184444
    Abstract: The present invention relates to composition containing novel proteins and method of using those compositions for the dignosis and treatment of immune related diseases.
    Type: Application
    Filed: August 11, 2004
    Publication date: August 9, 2007
    Inventors: Alexander Abbas, Hilary Clark, Wenjun Ouyang, P. Mickey Williams, William Wood, Thomas Wu
  • IL-17A/F heterologous polypeptides and therapeutic uses thereof
    Publication number: 20070160576
    Abstract: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
    Type: Application
    Filed: November 29, 2006
    Publication date: July 12, 2007
    Applicant: Genentech, Inc.
    Inventors: David Arnott, Mercedesz Balazs, Nico Ghilardi, Austin Gurney, Philip Hass, Sarah Hymowitz, James Lee, Wenjun Ouyang, Melissa Starovasnik, Yan Wu