Patents by Inventor Wenjun Wei

Wenjun Wei has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250115613
    Abstract: The present invention provides a diaryl compound as a tubulin/Src dual target inhibitor. The present invention also provides a diaryl compound represented by formula I, a tautomer, a stereoisomer, a solvate, a pharmaceutically acceptable salt, or a prodrug thereof. The diaryl compound can be used as a dual target inhibitor against tubulin and Src kinase and can also be used as a mono-target inhibitor against tubulin or Src kinase. The compound of the present invention can significantly inhibit the polymerization of tubulin monomers and cell proliferation.
    Type: Application
    Filed: January 13, 2023
    Publication date: April 10, 2025
    Applicant: Wuhan Humanwell Innovative Drug Research and Development Center Limited Company
    Inventors: Xuejun ZHANG, Yang ZANG, Hui YANG, Sijun LEI, Wenjun WEI, Zhiqiang WU, Lifei LIU, Xin ZHANG, Li'e LI, Jun YANG
  • Publication number: 20240287064
    Abstract: The present invention relates to a tricyclic compound used as a GPR84 antagonist, and in particular relates to a tricyclic compound having a structure shown in formula I, and tautomers, stereoisomers, hydrates, solvates, pharmaceutically acceptable salts or prodrugs thereof; the definitions of the ring Cy, L1, R1 are as described in the present invention; the tricyclic compound has significant GPR84 antagonism, good pharmaceutical developability and high safety.
    Type: Application
    Filed: June 21, 2022
    Publication date: August 29, 2024
    Applicant: Wuhan Humanwell Innovative Drug Research and Development Center Limited Company
    Inventors: Xuejun ZHANG, Yang ZANG, Wenjun WEI, Qun LI, Xin ZHAO, Qing XU, Ping NI, Li'e LI, Jun YANG
  • Publication number: 20220204479
    Abstract: The present disclosure relates to pyrimidine compounds, and more specifically, relates to pyrimidine compounds, preparation methods thereof, and uses thereof in manufacture of medicaments. Provided is a compound represented by Formula (I) or a tautomer, stereoisomer, hydrate, solvate, pharmaceutical acceptable salt, or prodrug of the compound represented by Formula (I). The compound has a significant inhibitory effect on ATX enzyme, exhibits excellent liver metabolism stability, is metabolized more slowly in the human body, and has higher exposure.
    Type: Application
    Filed: March 4, 2022
    Publication date: June 30, 2022
    Applicant: Wuhan Humanwell Innovative Drug Research And Development Center Limited Company
    Inventors: Xuejun ZHANG, Lie LI, Jie SHEN, Wenjun WEI, Sijun LEI, Xiaohua DING, Yang ZANG, Hongna SUN, Qiangqiang FU
  • Patent number: 9303108
    Abstract: The present invention relates to a propylene-butene-1 random copolymer which has a butene-1 content of 1-6 mol % and a relative dispersity of butene-1, as determined according to NMR method, of greater than 98.5%. The propylene-butene-1 random copolymer of the present invention has a high relative dispersity of butene-1, as well as better transparency and heat resistance, so that it is more suitable for packaging food that may be edible after heating. Moreover, the copolymer has a lower xylene solubles content at room temperature. In addition, the present invention further relates to a method for preparing the copolymer and to a composition and an article comprising the copolymer.
    Type: Grant
    Filed: October 29, 2012
    Date of Patent: April 5, 2016
    Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, BEIJING RESEARCH INSTITUTE OF CHEMICAL INDUSTRY, CHINA PETROLEUM & CHEMICAL CORPORATION
    Inventors: Meifang Guo, Wenbo Song, Liying Zhang, Liping Hou, Wenjun Wei, Hao Zhang, Yujing Tang, Huijie Hu
  • Patent number: 9068030
    Abstract: The present invention provides a process for preparing high melt strength propylene polymer by direct polymerization, comprising that a propylene polymer with wide molecular weight distribution and containing “very high molecular weight fraction” can be prepared by controlling the species and ratios of the external electron donors in the Ziegler-Natta catalyst system at different reaction stages according to the requirement for different molecular weight fractions in the different propylene polymerization stage of the series operation, and said polymer has excellent mechanical properties, especially with very high melt strength. The present invention also provides a propylene homopolymer with high melt strength, comprising the following features: (1) the MFR is 0.2-10 g/10 min at 230° C. with a load of 2.16 kg; (2) the molecular weight distribution Mw/Mn is 6-20; (3) the content of the fraction with a molecular weight higher than 5,000,000 is higher than or equal to 0.
    Type: Grant
    Filed: January 21, 2011
    Date of Patent: June 30, 2015
    Assignees: China Petroleum & Chemical Corporation, Beijing Research Institute of Chemical Industry, China Petroleum & Chemical Corporation
    Inventors: Wenbo Song, Meifang Guo, Shijun Zhang, Wenjun Wei, Honghong Huang, Luqiang Yu, Tao Liu, Huijie Hu, Huan Xu, Peiqian Yu, Xiaomeng Zhang
  • Publication number: 20130023598
    Abstract: The present invention provides a process for preparing high melt strength propylene polymer by direct polymerization, comprising that a propylene polymer with wide molecular weight distribution and containing “very high molecular weight fraction” can be prepared by controlling the species and ratios of the external electron donors in the Ziegler-Natta catalyst system at different reaction stages according to the requirment for different molecular weight fractions in the different propylene polymerization stage of the series operation, and said polymer has excellent mechnical properties, especially with very high melt strength. The present invention also provides a propylene homopolymer with high melt strength, comprising the following features: (1) the MFR is 0.2-10 g/10 min at 230° C. with a load of 2.16 kg; (2) the molecular weight distribution Mw/Mn is 6-20; (3) the content of the fraction with a molecular weight higher than 5,000,000 is higher than or equal to 0.
    Type: Application
    Filed: January 21, 2011
    Publication date: January 24, 2013
    Inventors: Wenbo Song, Meifang Guo, Shijun Zhang, Wenjun Wei, Honghong Huang, Luqiang Yu, Tao Liu, Huijie Hu, Huan Xu, Peiqian Yu, Xiaomeng Zhang