Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

Abstract: The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

Abstract: The present invention provides an IP telephone gatekeeper system and an implementation method thereof, characterized in that two or more individual gatekeepers are connected each other, so as to forming a gatekeeper system that can be regarded as a single gatekeeper system by the controlled gateways, in which the gatekeepers can substitute and backup mutually. A plurality of computer systems are used to realized the cooperation of a plurality of gatekeepers, for breaking through the limit of capacity of individual gatekeeper group and improving the reliability of the whole system, so that backing-up and substituting mutually can be achieved.

Abstract: The present invention relates to a method for generating a charge ID in Internet ONLY service, generating the charge ID that includes printable characters using a call ID in the IP gateway; the process is simple and resulted charge ID is absolutely unique. Wherein including: configuring the charge ID including 32 printable characters, each of which is represented with 4 binary bits; taking the call ID including 16 characters, each of which is represented with 8 binary bits; corresponding each call ID character with two charge ID characters, wherein the upper four from eight bits of one of the call ID characters referring to 4 binary bits of one of the charge ID characters, the lower four bits corresponding to 4 binary bits of another charge ID character. Because the scope represented by four binary bits is from 0 to 15, the charge ID characters can exactly correspond one by one relationship with printable characters of 0-9 and A-F.

Abstract: The present invention provides an IP telephone gatekeeper system and an implementation method thereof, characterized in that two or more individual gatekeepers are connected each other, so as to forming a gatekeeper system that can be regarded as a single gatekeeper system by the controlled gateways, in which the gatekeepers can substitute and backup mutually. A plurality of computer systems are used to realized the cooperation of a plurality of gatekeepers, for breaking through the limit of capacity of individual gatekeeper group and improving the reliability of the whole system, so that backing-up and substituting mutually can be achieved.

Abstract: The present invention relates to a method for generating a charge ID in Internet ONLY service, generating the charge ID that includes printable characters using a call ID in the IP gateway; the process is simple and resulted charge ID is absolutely unique. Wherein including: configuring the charge ID including 32 printable characters, each of which is represented with 4 binary bits; taking the call ID including 16 characters, each of which is represented with 8 binary bits; corresponding each call ID character with two charge ID characters, wherein the upper four from eight bits of one of the call ID characters referring to 4 binary bits of one of the charge ID characters, the lower four bits corresponding to 4 binary bits of another charge ID character. Because the scope represented by four binary bits is from 0 to 15, the charge ID characters can exactly correspond one by one relationship with printable characters of 0-9 and A-F.