Abstract: Disclosed are a Micro-LED pixel arrangement structure, an arrangement method, and a display panel. The pixel arrangement structure comprises a plurality of pixel groups, each comprises a plurality of sub-pixels. The arrangement directions of the sub-pixels in the plurality of pixel groups on the leftmost column and in the plurality of pixel groups on the rightmost column are perpendicular to the arrangement direction of the sub-pixels in other pixel groups on the first row or the last row. The arrangement directions of the sub-pixels in the pixel groups on the leftmost column and in the pixel groups on the rightmost column in the Micro-LED pixel arrangement structure are perpendicular to the arrangement directions of the sub-pixels in other pixel groups on the first row or the last row, thereby avoiding edge color shift and improving the display quality.