Patents by Inventor Wenlan Liu

Wenlan Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Blood biomarker for early blood brain barrier disruption in ischemic stroke
    Patent number: 10591491
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Grant
    Filed: January 30, 2019
    Date of Patent: March 17, 2020
    Assignee: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • Blood biomarker for early blood brain barrier disruption in ischemic stroke
    Patent number: 10254295
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: April 9, 2019
    Assignee: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • BLOOD BIOMARKER FOR EARLY BLOOD BRAIN BARRIER DISRUPTION IN ISCHEMIC STROKE
    Publication number: 20170199205
    Abstract: Methods and apparatus for determining blood brain barrier (BBB)damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Application
    Filed: March 20, 2017
    Publication date: July 13, 2017
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • Blood biomarker for early blood brain barrier disruption in ischemic stroke
    Patent number: 9606129
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: March 28, 2017
    Assignee: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • Blood biomarker for early blood brain barrier disruption in ischemic stroke
    Patent number: 9599625
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: March 21, 2017
    Assignee: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • Blood Biomarker for Early Blood Brain Barrier Disruption in Ischemic Stroke
    Publication number: 20150198617
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Application
    Filed: April 2, 2015
    Publication date: July 16, 2015
    Applicant: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan
  • Blood Biomarker for Early Blood Brain Barrier Disruption in Ischemic Stroke
    Publication number: 20140314737
    Abstract: Methods and apparatus for determining blood brain barrier (BBB) damage and treating patients who may have suffered from BBB damage due to an ischemic event are provided. The methods and apparatus involve detecting the presence of cleaved occludin fragments in a sample of blood. According to some embodiments, the method further provides determining the degree of BBB damage based on the concentration of occludin fragments in the sample. In further embodiments the present disclosure provides kits for detecting the presence of occludin fragments in a blood sample.
    Type: Application
    Filed: July 7, 2014
    Publication date: October 23, 2014
    Applicant: STC.UNM
    Inventors: Ke Jian Liu, Wenlan Liu, Graham Timmins, Rong Pan