Abstract: The present invention belongs to the technical field of biological pharmacy, and particularly relates to a long-acting HM-3 fusion protein molecule and an application thereof. In the present invention, on the basis of the sequence of HM-3 molecule, an active polypeptide HM-3 and derivatives thereof are linked to a human Fc (IgG) fragment or a fragment of an Fc (IgG) mutant directly or by a linker peptide (Linker), thus forming a novel molecular entity. The general formula of the molecular entity is (HM-3)n-Linker-Fc(IgG), Fc(IgG)-Linker-(HM-3)n, or (HM-3)n-Linker-Fc(IgG)-Linker-(HM-3)n. The fusion protein effectively prolongs the half-life of HM-3, is low in cost and overcomes the major problem of druggability of small peptides. Therefore, the fusion protein of the present invention may serve as a potential drug for the treatment of autoimmune diseases, neovascular diseases, osteoarthritis and the like.

Abstract: The present invention belongs to the technical field of biological pharmacy, and particularly relates to a long-acting HM-3 fusion protein molecule and an application thereof. In the present invention, on the basis of the sequence of HM-3 molecule, an active polypeptide HM-3 and derivatives thereof are linked to a human Fc (IgG) fragment or a fragment of an Fc (IgG) mutant directly or by a linker peptide (Linker), thus forming a novel molecular entity. The general formula of the molecular entity is (HM-3)n-Linker-Fc(IgG), Fc(IgG)-Linker-(HM-3)n, or (HM-3)n-Linker-Fc(IgG)-Linker-(HM-3)n. The fusion protein effectively prolongs the half-life of HM-3, is low in cost and overcomes the major problem of druggability of small peptides. Therefore, the fusion protein of the present invention may serve as a potential drug for the treatment of autoimmune diseases, neovascular diseases, osteoarthritis and the like.

Abstract: The present disclosure provides an electrically controllable optical device and a method for operating the same. The electrically controllable optical device comprises a multi-stable liquid crystal layer and a controller, wherein the electrically controllable optical device is switchable between a transparent state and a non-transparent state. The method for operating the electrically controllable optical device comprises applying a voltage to the multi-stable liquid crystal layer, controlling at least one of the amplitude, frequency and number of pulses of the voltage to switch the electrically controllable optical device between a transparent state and a non-transparent state, and removing the voltage.

Abstract: The present invention relates to a high scattering smectic liquid crystal material and display device using the same. In the present invention, a series of smectic A phase liquid crystals having compact arrangement of crystal domains or a series of smectic liquid crystal mixed materials having a degree of order higher than that of the smectic A phase and an optical texture different from that of the smectic A phase are obtained by mixing a smectic liquid crystal with an organic compound having a high optical anisotropy (?n) or mixing different types of smectic phases. When used in a smectic stable state liquid crystal display pattern, these materials have high scattering properties and can effectively improve the contrast of a smectic liquid crystal display device. The present invention also improves contrast when it used in a reflective smectic liquid crystal display device.

Abstract: The present invention relates to a smectic A phase liquid crystal material, which contains at least one heterocyclic compound. The smectic A phase liquid crystal material of the present invention may further contain at least one ester compound and an ionic compound. By using the smectic A phase liquid crystal material in a display device, a displayed image can be completely erased without any residual images after a long-term placement or a long-term drive, the contrast is generally higher than 10, and the drive voltage is generally 20 to 50 V.

Abstract: The present invention relates to a high scattering smectic liquid crystal material and display device using the same. In the present invention, a series of smectic A phase liquid crystals having compact arrangement of crystal domains or a series of smectic liquid crystal mixed materials having a degree of order higher than that of the smectic A phase and an optical texture different from that of the smectic A phase are obtained by mixing a smectic liquid crystal with an organic compound having a high optical anisotropy (?n) or mixing different types of smectic phases. When used in a smectic stable state liquid crystal display pattern, these materials have high scattering properties and can effectively improve the contrast of a smectic liquid crystal display device. The present invention also improves contrast when it used in a reflective smectic liquid crystal display device.