Patents by Inventor Wenli Zheng
Wenli Zheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11568230Abstract: The present disclosure provides a method, a device and a computer readable storage medium for food risk traceability information classification.Type: GrantFiled: September 2, 2020Date of Patent: January 31, 2023Assignees: SHENZHEN ACADEMY OF INSPECTION AND QUARANTINE, SHENZHEN CUSTOMS INFORMATION CENTER, SHENZHEN CUSTOMS ANIMAL AND PLANT INSPECTION AND QUARATINE TECHNOLOGY CENTERInventors: Yina Cai, Xianyu Bao, Zhouxi Ruan, Wenli Zheng, Heping Li, Tikang Lu, Zhinan Chen
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Publication number: 20220282332Abstract: Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g., to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus.Type: ApplicationFiled: May 12, 2022Publication date: September 8, 2022Inventors: Yuk Ming Dennis Lo, Kwan Chee Chan, Wai Kwun Rossa Chiu, Wenli Zheng
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Patent number: 11365448Abstract: Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus.Type: GrantFiled: April 20, 2018Date of Patent: June 21, 2022Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Kwan Chee Chan, Wai Kwun Rossa Chiu, Wenli Zheng
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Publication number: 20220093212Abstract: A fractional concentration of fetal relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments of a particular size or range of sizes. DNA fragments may be sequenced to obtain sequence reads, and the sequence reads may be aligned to a reference genome to determine sizes of the DNA fragments. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a parameter providing a statistical measure of a size profile and the fractional concentration of the fetal DNA. For a given sample, a value of the parameter can be determined from DNA fragments of a particular size or range of sizes in a sample. A comparison of the value to the calibration data points can provide the estimate of the fractional concentration of the fetal DNA.Type: ApplicationFiled: November 5, 2021Publication date: March 24, 2022Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Publication number: 20220004947Abstract: The present disclosure provides a logistics route prediction method and apparatus. The method includes: obtaining chain network information of a logistics chain network corresponding to a logistics unit, and determining a target analysis domain and confidence node(s) of the logistics unit according to the chain network information; determining fast node(s) according to the chain network information, the target analysis domain, and a timeliness level of each of the logistics nodes in the logistics chain network; and determining a predicted logistics route corresponding to the logistics unit according to the chain network information, the target analysis domain, and the confidence node(s). In which, the fast nodes at which the logistics unit passing through is determined first, thereby improving the prediction efficiency, and the confidence nodes are used as the basis for determining the predicted logistics route among multiple possible flow routes, thereby improving the reliability of the prediction.Type: ApplicationFiled: August 31, 2020Publication date: January 6, 2022Inventors: Xianyu BAO, Lixun CHENG, Wenli ZHENG, Lijuan HE, Ruizhi HE, Yun GUO, Zhifeng QIN, Tikang LU, Jianzhong ZHONG
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Publication number: 20220004859Abstract: The present disclosure provides a method, a device and a computer readable storage medium for food risk traceability information classification.Type: ApplicationFiled: September 2, 2020Publication date: January 6, 2022Inventors: Yina Cai, Xianyu Bao, Zhouxi Ruan, Wenli Zheng, Heping Li, Tikang Lu, Zhinan Chen
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Publication number: 20220004986Abstract: The present disclosure provides a logistics node tracing method and apparatus for finding a trace node among logistics nodes in a logistics chain network corresponding to a logistics unit. The method includes: obtaining chain network information of a logistics chain network corresponding to a logistics unit, and determining a target analysis domain and confidence node(s) of the logistics unit according to the chain network information; determining fast node(s) according to the chain network information, the target analysis domain, and a timeliness level of each of the logistics nodes in the logistics chain network; determining a predicted logistics route corresponding to the logistics unit according to the chain network information, the target analysis domain, and the confidence node(s); and determining the trace node corresponding to the logistics unit according to the fast node(s) and the predicted logistics route.Type: ApplicationFiled: September 1, 2020Publication date: January 6, 2022Inventors: XIANYU BAO, Lixun CHENG, Wenli ZHENG, Yina CAI, Ruizhi HE, Heping LI, Tikang LU, Zhifeng QIN, Zhouxi RUAN
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Patent number: 11217330Abstract: A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA.Type: GrantFiled: January 30, 2018Date of Patent: January 4, 2022Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Patent number: 11108676Abstract: A method for detecting network quality includes: acquiring, by a data processing device, file download rates of a first node for files on a second node in a target time period within a pre-defined number of historical rate-collecting cycles; determining, by the data processing device, a plurality of network quality detection parameters from the first node to the second node in the target time period based on the file download rates, where the plurality of network quality detection parameters include a regular network speed, a network speed fluctuation range, and a network speed lower limit; creating, by the data processing device, a network fluctuation model from the first node to the second node in the target time period based on the plurality of network quality detection parameters and respective pre-defined weights, and providing the network fluctuation model to a central scheduling device; and detecting, by the central scheduling device, a network quality from the first node to the second node in the targType: GrantFiled: June 14, 2018Date of Patent: August 31, 2021Assignee: WANGSU SCIENCE & TECHNOLOGY CO., LTD.Inventors: Meihong Huang, Wenli Zheng
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Publication number: 20210251309Abstract: A wearable device and a system, the wearable device including a wearable textile body including a plurality of interwoven or knitted yarns; one or more textile sensors each located at an area on the wearable textile body, each textile sensor including a plurality of functional yarns integrally interwoven or knitted with the yarns of the wearable textile body at the located area; and an interface communicatively coupled with the one or more textile sensors.Type: ApplicationFiled: March 23, 2020Publication date: August 19, 2021Inventors: Zhengrong TANG, Wenli Zheng, Zhen Cai
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Publication number: 20210257053Abstract: A fractional concentration of tumor DNA in a plasma sample is estimated by analyzing a biological sample of an organism. One or more sequence reads obtained from a sequencing of the DNA fragment are received. The one or more sequence reads are aligned to a reference genome to obtain aligned locations for both ends of the DNA fragment. Using the aligned locations, a size of the DNA fragment is determined. For each size of a plurality of sizes, an amount of a set of the plurality of DNA fragments from the plasma sample corresponding to the size is determined. A first value of a first parameter is calculated based on the amounts of DNA fragments at multiple sizes. The first value is compared to a calibration value. A fractional concentration of tumor DNA in the plasma sample is estimated based on the comparison.Type: ApplicationFiled: May 6, 2021Publication date: August 19, 2021Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Patent number: 11031100Abstract: A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.Type: GrantFiled: June 26, 2020Date of Patent: June 8, 2021Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Publication number: 20210105201Abstract: A method for detecting network quality includes: acquiring, by a data processing device, file download rates of a first node for files on a second node in a target time period within a pre-defined number of historical rate-collecting cycles; determining, by the data processing device, a plurality of network quality detection parameters from the first node to the second node in the target time period based on the file download rates, where the plurality of network quality detection parameters include a regular network speed, a network speed fluctuation range, and a network speed lower limit; creating, by the data processing device, a network fluctuation model from the first node to the second node in the target time period based on the plurality of network quality detection parameters and respective pre-defined weights, and providing the network fluctuation model to a central scheduling device; and detecting, by the central scheduling device, a network quality from the first node to the second node in the targType: ApplicationFiled: June 14, 2018Publication date: April 8, 2021Inventors: Meihong HUANG, Wenli ZHENG
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Publication number: 20200327960Abstract: A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.Type: ApplicationFiled: June 26, 2020Publication date: October 15, 2020Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Patent number: 10741270Abstract: A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.Type: GrantFiled: January 20, 2017Date of Patent: August 11, 2020Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Patent number: 10297342Abstract: A classification of a level of cancer in an organism is determined by analyzing a biological sample of the organism. The biological sample comprises clinically-relevant DNA and other DNA. At least some of the DNA is cell-free in the biological sample. An amount of a first set of DNA fragments from the biological sample corresponding to each of a plurality of sizes is measured. A first value of a first parameter is calculated based on the amounts of DNA fragments at the plurality of sizes. The first value is compared to a reference value. A classification of a level of cancer in the organism is determined based on the comparison.Type: GrantFiled: May 5, 2017Date of Patent: May 21, 2019Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Publication number: 20180237858Abstract: Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus.Type: ApplicationFiled: April 20, 2018Publication date: August 23, 2018Inventors: Yuk Ming Dennis Lo, Kwan Chee Chan, Wai Kwun Rossa Chiu, Wenli Zheng
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Publication number: 20180157793Abstract: A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA.Type: ApplicationFiled: January 30, 2018Publication date: June 7, 2018Inventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao
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Patent number: 9982300Abstract: Systems, methods, and apparatuses for performing a prenatal diagnosis of a sequence imbalance are provided. A shift (e.g. to a smaller size distribution) can signify an imbalance in certain circumstances. For example, a size distribution of fragments of nucleic acids from an at-risk chromosome can be used to determine a fetal chromosomal aneuploidy. A size ranking of different chromosomes can be used to determine changes of a rank of an at-risk chromosome from an expected ranking. Also, a difference between a statistical size value for one chromosome can be compared to a statistical size value of another chromosome to identify a significant shift in size. A genotype and haplotype of the fetus may also be determined using a size distribution to determine whether a sequence imbalance occurs in a maternal sample relative to a genotypes or haplotype of the mother, thereby providing a genotype or haplotype of the fetus.Type: GrantFiled: November 25, 2013Date of Patent: May 29, 2018Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Kwan Chee Chan, Wai Kwun Rossa Chiu, Wenli Zheng
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Patent number: 9892230Abstract: A fractional concentration of clinically-relevant DNA in a mixture of DNA from a biological sample is determined based on amounts of DNA fragments at multiple sizes. For example, the fractional concentration of fetal DNA in maternal plasma or tumor DNA in a patient's plasma can be determined. The size of DNA fragments in a sample is shown to be correlated with a proportion of fetal DNA and a proportion of tumor DNA, respectively. Calibration data points (e.g., as a calibration function) indicate a correspondence between values of a size parameter and the fractional concentration of the clinically-relevant DNA. For a given sample, a first value of a size parameter can be determined from the sizes of DNA fragments in a sample. A comparison of the first value to the calibration data points can provide the estimate of the fractional concentration of the clinically-relevant DNA.Type: GrantFiled: March 7, 2013Date of Patent: February 13, 2018Assignee: The Chinese University of Hong KongInventors: Yuk Ming Dennis Lo, Wai Kwun Rossa Chiu, Kwan Chee Chan, Wenli Zheng, Peiyong Jiang, Jiawei Liao