Abstract: The present disclosure relates to a tobacco flavoring machine, comprising: a drum (1) capable of rotating about an axis thereof as a rotation center; a nozzle (6) disposed in the drum (1) to spray a liquid flavor to tobacco shreds in the drum (1); and a shoveling plate (5) arranged on an inner wall (11) of the drum (1) and extending from an inlet end of the drum (1) towards the interior of the drum (1), the shoveling plate (5) being disposed obliquely with respect to a generatrix (9) of the drum (1). The present disclosure improves the problem of the related art that tobacco shreds cannot flow smoothly from an inlet end toward an outlet end because a shoveling plate (5) is parallel to an axis of a drum (1).

Abstract: The invention in one aspect relates to recombinant replication competent adenovirus that can replicate in and lyse a host cell comprising in the genome of the adenovirus a coding sequence for a glycogen synthase kinase-3 (GSK3) protein operably linked to an expression control sequence. It also relates, among others, to means and methods for treatment of cancer with a coding sequence for a glycogen synthase kinase-3 (GSK3) protein operably linked to an expression control sequence, preferably in the context of an adenovirus. This work was funded in part by European Union Horizon 2020 research and innovation programme, Marie-Sklodowska-Curie grant number 643130.

Abstract: The present disclosure relates to a tobacco flavoring machine, comprising: a drum (1) capable of rotating about an axis thereof as a rotation center; a nozzle (6) disposed in the drum (1) to spray a liquid flavor to tobacco shreds in the drum (1); and a shoveling plate (5) arranged on an inner wall (11) of the drum (1) and extending from an inlet end of the drum (1) towards the interior of the drum (1), the shoveling plate (5) being disposed obliquely with respect to a generatrix (9) of the drum (1). The present disclosure improves the problem of the related art that tobacco shreds cannot flow smoothly from an inlet end toward an outlet end because a shoveling plate (5) is parallel to an axis of a drum (1).

Abstract: The invention in one aspect relates to recombinant replication competent adenovirus that can replicate in and lyse a host cell comprising in the genome of the adenovirus a coding sequence for a glycogen synthase kinase-3 (GSK3) protein operably linked to an expression control sequence. It also relates, among others, to means and methods for treatment of cancer with a coding sequence for a glycogen synthase kinase-3 (GSK3) protein operably linked to an expression control sequence, preferably in the context of an adenovirus. This work was funded in part by European Union Horizon 2020 research and innovation programme, Marie-Sklodowska-Curie grant number 643130.