Patents by Inventor Wenlii Lin

Wenlii Lin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Enhanced large scale cultivation of bordetella pertussis cells for vaccine production using lactoglobulin
    Patent number: 4699786
    Abstract: A Bordetella pertussis vaccine is prepared by deep tank cultivation using a seed grown in a biphasic culture system. An anion exchange resin in combination with .beta.-lactoglobulin and a Modified Cohen-Wheeler or Modified Stainer-Schlolte medium is used in the process resulting in enhancement of the growth, antigen production and potency of the phase I Bordetella pertussis vaccine. An acellular Bordetella pertussis vaccine derived from the culture broth and cells of Bordetella pertussis useful in preparing an acellular vaccine and which are grown in a medium containing .beta.-lactoglobulin and an anion exchange resin is also disclosed.
    Type: Grant
    Filed: May 9, 1986
    Date of Patent: October 13, 1987
    Assignee: American Cyanamid Company
    Inventors: Wenlii Lin, William A. Griffith
  • Multivalent pneumococcal vaccine and preparation thereof
    Patent number: 4686102
    Abstract: A multivalent pneumococcal vaccine consisting of immunogenic amounts of purified pneumococcal capsular polysaccharide (substantially absent "C" polysaccharide) of pneumococcal types (Danish designation) 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F and 33F, and from none to one or both of 6A and 25, and combinations thereof and methods of purifying pneumococcal capsular polysaccharide types 3, 5, 9V, 10A, 11A, 15B, 17F, 19A, 22F and 33F.
    Type: Grant
    Filed: April 12, 1984
    Date of Patent: August 11, 1987
    Assignee: American Cyanamid Company
    Inventors: Mary B. Ritchey, Francis R. Cano, Gerald J. O'Hara, James D. English, Wenlii Lin
  • Large scale cultivation of Bordetella pertussis cells for vaccine production
    Patent number: 4429046
    Abstract: A Bordetella pertussis vaccine is prepared by deep tank cultivation using a seed grown in a biphasic culture system. An anion exchange resin and a Modified Cohen-Wheeler medium used in the process, results in increased antigenicity and a minimization of toxicity in the phase I Bordetella pertussis vaccine.
    Type: Grant
    Filed: July 26, 1982
    Date of Patent: January 31, 1984
    Assignee: American Cyanamid Company
    Inventors: Wenlii Lin, John W. Imbaratto