Abstract: Provided are targeting conjugates comprising a targeting moiety and an effector molecule, wherein the effector molecule is conjugated to the targeting moiety via a conjugation site, wherein the effector molecule can be released from the targeting conjugate via cleavage. Also provided are compositions and methods of treatment or diagnosis using the targeting conjugates.

Abstract: Provided are targeting conjugates comprising a targeting moiety, a therapeutic agent, and an oligonucleotide, wherein the oligonucleotide is attached to the targeting moiety via a targeting moiety binding fragment (TBF), wherein the therapeutic agent and/or the oligonucleotide can be released from the targeting conjugate via cleavage. Also provided are pharmaceutical compositions and methods of treatment using the targeting conjugates.

Abstract: An embedded protrusion integrated condom, a manufacturing process, and a piece of special production equipment are disclosed. The condom includes a condom body and a function adjusting component configured to adjust the usage effect. The manufacturing process includes a condom body forming step, a function part paste step, a function part embedding step, and an embedded condom body structure reinforcement step. The special production equipment includes a multi-station synchronous impregnation mold, at least one series of combined impregnation pool, a control system, an automatic latex brush mechanism matching the combined impregnation pool, an automatic paste mechanism, and an automatic blanking mechanism. The condom has the usage effects such as good body touch effect and being able to realize physical delay; the manufacturing process and the special production equipment has the technical advantages of high automation degree, high production efficiency, and the like.

Abstract: An apparatus for purifying sodium metal including: a top flange, a transparent slice, a hollow flange, a vacuum distillation kettle, gaskets, and bolts. With this apparatus, solid sodium is liquefied by heating. The volatile impurities contained in the liquid sodium metal evaporate out of the vacuum pump. After heating the liquid sodium to a high temperature, circulating cooling water is added to the condenser tube by radiation-auxiliary distillation. High-purity argon is then added to remove volatile impurities, and thermal radiation is performed to accelerate the evaporation rate at the surface of the liquid sodium. Consequently, gaseous sodium rapidly condenses on the condenser tube and becomes solid sodium.

Abstract: This invention provides a method to purify sodium metal. The developed apparatus consists of a top flange, a transparent slice, a hollow flange, a vacuum distillation kettle, gaskets, and bolts. With this apparatus, solid sodium is liquefied by heating. The volatile impurities contained in the liquid sodium metal evaporate out of the vacuum pump. After heating the liquid sodium to a high temperature, circulating cooling water is added to the condenser tube by radiation-auxiliary distillation. High-purity argon is then added to remove volatile impurities, and thermal radiation is performed to accelerate the evaporation rate at the surface of the liquid sodium. Consequently, gaseous sodium rapidly condenses on the condenser tube and becomes solid sodium. Thermal radiation-auxiliary distillation is finally realized to refine sodium metal.