Abstract: The present disclosure provides a display substrate and a display device. The display substrate includes a test area, the test area includes a plurality of signal lines coupled to signal lines in a display area of the display substrate, the signal lines are divided into a plurality of groups, each group of signal lines in at least a portion of the groups are coupled through a plurality of shorting bars, and each of the shorting bars is coupled to a same group of signal lines.

Abstract: The present disclosure relates to a counter substrate and display panel. The counter substrate includes a base substrate, PS pattern layer and alignment film. A surface of the PS pattern layer away from the base substrate is a support surface, and the PS pattern layer includes: main PSs in a display area and a peripheral barrier wall in a non-display area. The peripheral barrier wall has an elongated-strip shape and has a same length direction as a corresponding display area side, the support surface of the peripheral barrier wall is closer to the base substrate than that of the main PS, and a distance between the support surfaces of the peripheral barrier wall and main PS in a thickness direction is a first distance.

Abstract: Provided is a liquid crystal display panel, including an array substrate and a color filter substrate that are arranged oppositely, and a plurality of photo spacers disposed between the array substrate and the color filter substrate. The array substrate is provided with a plurality of via holes, wherein the plurality of via holes are arranged in an array along two directions. In at least one of the two directions, widths of target end faces of at least part of the plurality of photo spacers are greater than widths of first opening faces of the via holes, wherein the target end face of the photo spacer is an end face, proximal to the array substrate, of the photo spacer, and the first opening face of the via hole is an opening face, proximal to the color filter substrate, of the via hole.

Abstract: The present disclosure provides a thin film transistor liquid crystal display panel and a preparation method thereof. The display panel has an array substrate, an opposite substrate and a frame sealant, and has a substrate layer, a first protective passivation layer, an organic film layer, and a second protective passivation layer, wherein an orthographic projection of the second protective passivation layer on the substrate extends to an outer region outside the frame sealant. The display panel further has a water insulation layer, which covers a portion of the second protective passivation layer where its orthographic projection on the substrate layer is in the outer region, such that the second protective passivation layer is not in contact with an external environment of the display panel.

Abstract: Provided is a display substrate. The display substrate includes a base substrate, a patterned film disposed on a side of the base substrate, and a planarization film disposed on a side, distal from the base substrate, of the patterned film, wherein a surface, distal from the base substrate, of the patterned film has a depressed portion and a non-depressed portion. A thickness of the depressed portion is less than a thickness of the non-depressed portion, and lyophilicity of the depressed portion is higher than the lyophilicity of the non-depressed portion.

Abstract: The present disclosure provides an array substrate and a method of manufacturing the same and a display panel, which belongs to the field of display technologies. The method of manufacturing the array substrate comprises: providing a base substrate; forming a drive circuit layer on the base substrate, wherein the drive circuit layer includes a switching transistor; forming an insulating material layer on one side of the drive circuit layer distal to the base substrate, wherein the insulating material layer has a connection via-hole exposing at least a part region of a drain electrode of the switching transistor; and forming an electrode layer on one side of the insulating material layer distal to the base substrate, wherein a surface of the electrode layer distal to the base substrate has groove structures extending to the connection via-hole.

Abstract: A drug conjugate of a glucocorticoid receptor agonist, and an application thereof in medicine. Specifically, the present invention relates to an antibody-drug conjugate as represented by formula (I): Ab-(L-D)k (I), wherein Ab is an antibody or an antigen-binding fragment thereof, L is a linker covalently linking Ab to D, k is 1 to 20, and D is as represented by formula (II-A) or (II-B). The groups in the formulas are as defined in the description. The antibody-drug conjugate can effectively treat autoimmune diseases.

Abstract: The present disclosure provides an array substrate and a method of manufacturing the same and a display panel, which belongs to the field of display technologies. The method of manufacturing the array substrate comprises: providing a base substrate; forming a drive circuit layer on the base substrate, wherein the drive circuit layer includes a switching transistor; forming an insulating material layer on one side of the drive circuit layer distal to the base substrate, wherein the insulating material layer has a connection via-hole exposing at least a part region of a drain electrode of the switching transistor; and forming an electrode layer on one side of the insulating material layer distal to the base substrate, wherein a surface of the electrode layer distal to the base substrate has groove structures extending to the connection via-hole. The manufacturing method may avoid the occurrence of poor coating in forming an orientation layer.

Abstract: An array substrate includes: a substrate, and a thin film transistor TFT, a first passivation layer and a transparent electrode disposed on the substrate. Only the first passivation layer is disposed between the transparent electrode and an active layer in the TFT. In this way, a film structure of the array substrate is effectively simplified because no organic insulation layer is disposed in the array substrate, thereby simplifying a manufacturing process of the array substrate and reducing the manufacturing cost of the array substrate.

Abstract: The present disclosure relates to a counter substrate and display panel. The counter substrate includes a base substrate, PS pattern layer and alignment film. A surface of the PS pattern layer away from the base substrate is a support surface, and the PS pattern layer includes: main PSs in a display area and a peripheral barrier wall in a non-display area. The peripheral barrier wall has an elongated-strip shape and has a same length direction as a corresponding display area side, the support surface of the peripheral barrier wall is closer to the base substrate than that of the main PS, and a distance between the support surfaces of the peripheral barrier wall and main PS in a thickness direction is a first distance.

Abstract: A drug-loaded macromolecule and a preparation method therefor, the macromolecule specifically being a dentritic polymer loaded with a drug and a pharmacokinetic modifier, and relating in particular to connecting the drug to the dentritic polymer by means of a specific linker. The present macromolecule can be used to regulate the release speed of the drug, specifically by means of the selection of linker.

Abstract: Provided are an anti-CD79B antibody-drug conjugate, and a preparation method therefor and pharmaceutical use thereof. In particular, provided are an antibody-drug conjugate (ADC) which comprises an anti-CD79B antibody conjugated with an MMAE or a derivative thereof, exatecan or a derivative thereof, or Eribulin or a derivative thereof, a pharmaceutical composition containing the ADC, and use thereof in preparation of a drug for treatment of a CD79B-mediated disease or disorder, especially use thereof in preparation of an anti-cancer drug.

Abstract: The present disclosure relates to a counter substrate and display panel. The counter substrate includes a base substrate, PS pattern layer and alignment film. A surface of the PS pattern layer away from the base substrate is a support surface, and the PS pattern layer includes: main PSs in a display area and a peripheral barrier wall in a non-display area. The peripheral barrier wall has an elongated-strip shape and has a same length direction as a corresponding display area side, the support surface of the peripheral barrier wall is closer to the base substrate than that of the main PS, and a distance between the support surfaces of the peripheral barrier wall and main PS in a thickness direction is a first distance. A ratio between a width of the support surface of the peripheral barrier wall and the first distance is less than 100.

Abstract: A pick-and-place device of display screen substrate and a control method for picking and placing a display screen substrate are disclosed. The pick-and-place device of display screen substrate includes a housing, a support assembly and a control component. The support assembly is disposed in the housing and includes: a support plate extending in a first direction, and two sets of support bars disposed opposite to each other and spaced apart from each other in the first direction. Each set of support bars includes a plurality of support bars arranged at intervals along a second direction, and each support bars is movable in a third direction. The support plate and the support bar are connected with the housing respectively, and the support plate is provided with an opening configured to allow the support bar to move along the third direction.

Abstract: The present disclosure relates to a drug conjugate of an Eribulin derivative, a preparation method therefor and an application thereof in medicine. Specifically, provided is an antibody-drug conjugate, which contains an Eribulin derivative drug portion. The present disclosure further relates to a method for treating cancer by administering the antibody-drug conjugate provided herein.

Abstract: A liquid crystal aligning agent includes polymer(s) from at least one of polyamic acid and group of polyimides by ring closure thereof. The acid includes a first segment structure formed by first dianhydride of formula (I) and first diamine of formula (II) or (III). X1 is an amorphous first soft segment. L is single bond, double bond, divalent or trivalent hydrocarbon group having 1 to 3 Cs. Y1 is single bond, O, NH, S, unsaturated double bond(s), or aliphatic, aromatic, heterocyclic or fused ring. One A1 and one A2, combined with Y1, are each C. Remaining A1s and A2s are each CH, CR or N. Z1 is aliphatic, aromatic, heterocyclic or fused ring. A3s and A4s are each CH, CR or N. Neither of numbers of Ns in the A1s, A2s, A3s and A4s is more than two, R1, R2 and R are each hydrogen or aliphatic hydrocarbon group.

Abstract: The present disclosure relates to a counter substrate and display panel. The counter substrate includes a base substrate, PS pattern layer and alignment film. A surface of the PS pattern layer away from the base substrate is a support surface, and the PS pattern layer includes: main PSs in a display area and a peripheral barrier wall in a non-display area. The peripheral barrier wall has an elongated-strip shape and has a same length direction as a corresponding display area side, the support surface of the peripheral barrier wall is closer to the base substrate than that of the main PS, and a distance between the support surfaces of the peripheral barrier wall and main PS in a thickness direction is a first distance. A ratio between a width of the support surface of the peripheral barrier wall and the first distance is less than 100.

Abstract: The present disclosure relates to a counter substrate and display panel. The counter substrate includes a base substrate, PS pattern layer and alignment film. A surface of the PS pattern layer away from the base substrate is a support surface, and the PS pattern layer includes: main PSs in a display area and a peripheral barrier wall in a non-display area. The peripheral barrier wall has an elongated-strip shape and has a same length direction as a corresponding display area side, the support surface of the peripheral barrier wall is closer to the base substrate than that of the main PS, and a distance between the support surfaces of the peripheral barrier wall and main PS in a thickness direction is a first distance. A ratio between a width of the support surface of the peripheral barrier wall and the first distance is less than 100.

Abstract: The present disclosure provides a thin film transistor liquid crystal display panel and a preparation method thereof. The display panel has an array substrate, an opposite substrate and a frame sealant, and has a substrate layer, a first protective passivation layer, an organic film layer, and a second protective passivation layer, wherein an orthographic projection of the second protective passivation layer on the substrate extends to an outer region outside the frame sealant. The display panel further has a water insulation layer, which covers a portion of the second protective passivation layer where its orthographic projection on the substrate layer is in the outer region, such that the second protective passivation layer is not in contact with an external environment of the display panel.

Abstract: The present disclosure provides an array substrate and a method of manufacturing the same and a display panel, which belongs to the field of display technologies. The method of manufacturing the array substrate comprises: providing a base substrate; forming a drive circuit layer on the base substrate, wherein the drive circuit layer includes a switching transistor; forming an insulating material layer on one side of the drive circuit layer distal to the base substrate, wherein the insulating material layer has a connection via-hole exposing at least a part region of a drain electrode of the switching transistor; and forming an electrode layer on one side of the insulating material layer distal to the base substrate, wherein a surface of the electrode layer distal to the base substrate has groove structures extending to the connection via-hole. The manufacturing method may avoid the occurrence of poor coating in forming an orientation layer.