Abstract: The present invention discloses the use of an alkaloid compound in the preparation of products for the prevention and/or treatment of cardiac damage. Activity studies are conducted on the alkaloid compound, and it is verified that the alkaloid compound provided by the present invention is capable of inhibiting apoptosis induced by cardiotoxic effects. Specifically, it can inhibit cardiomyocyte apoptosis induced by the anthracycline DOX by down-regulating the expression level of p-JNK and/or Cleaved-Caspase-3, thus preventing and/or treating cardiomyocyte toxicity. The alkaloid compound can be used in the preparation of drugs for the prevention and/or treatment of diseases related to cardiac damage.

Abstract: The disclosure provides a use of an alkaloid compound Hip in treatment and/or prevention of cardiac trauma. Upon studying activity of the alkaloid compound Hip, it is verified that the alkaloid compound Hip provided in the disclosure can inhibit apoptosis induced by cardiomyocyte toxicity, through down-regulating expression levels of p-JNK and/or Cleaved-Caspase-3 to inhibit anthracycline DOX-induced cardiomyocyte apoptosis, thereby alleviating cardiomyocyte toxicity to achieve treatment and/or prevention of cardiomyocyte toxicity. Thus, the alkaloid compound Hip can be used to manufacture a medicine for treatment and/or prevention of myocardial injury-related diseases.