Patents by Inventor Wenqing LIN

Wenqing LIN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination Therapy Comprising A2A/A2B and PD-1/PD-L1 Inhibitors
    Publication number: 20250041310
    Abstract: The present application provides methods of treating cancer using a combination of an inhibitor of A2A and/or A2B and an inhibitor of PD-1 and/or PD-L1.
    Type: Application
    Filed: July 10, 2024
    Publication date: February 6, 2025
    Inventors: Hui Wang, Peter Niels Carlsen, Taisheng Huang, Yong Li, Luping Lin, Chao Qi, Pramod Unnikrishnan Thekkat, Xiaozhao Wang, Liangxing Wu, Wenqing Yao, Wenyu Zhu
  • METHOD FOR PREPARING (S)-NICOTINE BY REDUCTION
    Publication number: 20240124908
    Abstract: A method for preparing (S)-nicotine by reduction includes conducting a reduction process on an alkene compound as shown in Formula I and/or an iminium cation compound as shown in Formula II, thereby producing (S)-nicotine. The method is simple, safe, reliable, and yields both high purity and high quantities of (S)-nicotine production.
    Type: Application
    Filed: November 28, 2023
    Publication date: April 18, 2024
    Inventors: Wenqing LIN, Hongjie ZHENG, Xiaobo LIU, Zecong CHEN, Lingyu LI, Qingjun ZHOU, Songhe WANG, Yongtang YUE, Jicheng HU, Yue ZHANG, Shanshan MIAO
  • Method of preparation of (1R,3S)-3-amino-1-cyclopentanol and salt thereof
    Patent number: 11459291
    Abstract: Provided is a method of preparation of (1R, 3S)-3-amino-1-cyclopentanol, the method including: contacting N-acylhydroxyamine and cyclopentadiene for an asymmetric cycloaddition, to yield a first intermediate I; hydrogenating the first intermediate I to yield a second intermediate II; hydrolyzing, ammonolyzing, hydrazinolyzing, or alcoholyzing an amido bond of the second intermediate II to yield a third intermediate III; and hydrogenating the third intermediate III to yield (1R, 3S)-3-amino-1-cyclopentanol.
    Type: Grant
    Filed: January 31, 2021
    Date of Patent: October 4, 2022
    Assignee: PORTON PHARMA SOLUTIONS LTD.
    Inventors: Wenqing Lin, Hongjie Zheng, Jianping Zhu, Yong Zhang, Jianchong Wang
  • METHOD OF PREPARATION OF (1R,3S)-3-AMINO-1-CYCLOPENTANOL AND SALT THEREOF
    Publication number: 20210147339
    Abstract: Provided is a method of preparation of (1R, 3S)-3-amino-1-cyclopentanol, the method including: contacting N-acylhydroxyamine and cyclopentadiene for an asymmetric cycloaddition, to yield a first intermediate I; hydrogenating the first intermediate I to yield a second intermediate II; hydrolyzing, ammonolyzing, hydrazinolyzing, or alcoholyzing an amido bond of the second intermediate II to yield a third intermediate III; and hydrogenating the third intermediate III to yield (1R, 3S)-3-amino-1-cyclopentanol.
    Type: Application
    Filed: January 31, 2021
    Publication date: May 20, 2021
    Inventors: Wenqing LIN, Hongjie ZHENG, Jianping ZHU, Yong ZHANG, Jianchong WANG
  • Rosuvastatin calcium intermediate and method for preparing the same
    Patent number: 8933269
    Abstract: A method for preparing a rosuvastatin calcium intermediate, including a) contacting a halogenated ethene with magnesium metal to obtain a halogenated ethene Grignard reagent, and carrying out a Grignard reaction between the halogenated ethene Grignard reagent and R-epichlorohydrin; b) adding sodium cyanide for carrying out a nucleophilic substitution reaction; c) adding alcohol for carrying out an alcoholysis reaction; d) adding a basic solvent for carrying out protection of a first hydroxyl group; e) selectively oxidizing a second hydroxyl group; and f) adding triphenylphosphine in alkaline condition for carrying out a Wittig reaction.
    Type: Grant
    Filed: August 16, 2012
    Date of Patent: January 13, 2015
    Assignee: Porton Fine Chemicals Ltd.
    Inventors: Wenqing Lin, Hongjie Zheng, Xiaobo Liu
  • Method for preparing rosuvastatin calcium intermediate
    Patent number: 8703944
    Abstract: A method for preparing a rosuvastatin calcium intermediate represented by formula I. The method includes: hydrolyzing an ester compound represented by formula II (in which, R represents C1-C5) in the presence of a metal compound to obtain a carboxylic acid compound represented by formula III; and reducing the carboxylic acid compound in the presence of a reductant.
    Type: Grant
    Filed: February 3, 2013
    Date of Patent: April 22, 2014
    Assignee: Porton Fine Chemicals Ltd.
    Inventors: Wenqing Lin, Hongjie Zheng, Peng Yang
  • ROSUVASTATIN CALCIUM INTERMEDIATE AND METHOD FOR PREPARING THE SAME
    Publication number: 20120310000
    Abstract: A method for preparing a rosuvastatin calcium intermediate, including a) contacting a halogenated ethene with magnesium metal to obtain a halogenated ethene Grignard reagent, and carrying out a Grignard reaction between the halogenated ethene Grignard reagent and R-epichlorohydrin; b) adding sodium cyanide for carrying out a nucleophilic substitution reaction; c) adding alcohol for carrying out an alcoholysis reaction; d) adding a basic solvent for carrying out protection of a first hydroxyl group; e) selectively oxidizing a second hydroxyl group; and f) adding triphenylphosphine in alkaline condition for carrying out a Wittig reaction.
    Type: Application
    Filed: August 16, 2012
    Publication date: December 6, 2012
    Applicant: PORTON FINE CHEMICALS LTD.
    Inventors: Wenqing LIN, Hongjie ZHENG, Xiaobo LIU