Patents by Inventor Wenqiu Liu

Wenqiu Liu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 5 NM Nickel-NTA-Gold Nanoparticles
    Publication number: 20120244075
    Abstract: The present disclosure relates to the product, process, and use of 5 nm Nickel-Nitrilotriacetic acid (Ni-NTA) gold nanoparticles. Applications include diagnostic tests, imaging, therapies, detection technologies, gold conjugation to other molecules, and novel material constructs.
    Type: Application
    Filed: March 25, 2011
    Publication date: September 27, 2012
    Applicant: Nanoprobes, Inc.
    Inventors: Wenqiu Liu, James F. Hainfeld
  • Kit for enzymatic deposition of a metal
    Patent number: 7951554
    Abstract: The present invention provides compositions, kits, assemblies of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention concerns using enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to linking of metals to enzyme substrates, control of enzymatic metal deposition and applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using microscopy.
    Type: Grant
    Filed: February 17, 2010
    Date of Patent: May 31, 2011
    Assignee: Nanoprobes, Inc.
    Inventors: James F. Hainfeld, Wenqiu Liu
  • Method for detecting a target using enzyme directed deposition of elemental metal
    Patent number: 7888060
    Abstract: Disclosed embodiments concern site-specific, enzymatic-directed deposition of elemental metal for in-situ analysis. Enzyme substrates are contacted with metal ions and subsequently direct the deposition of elemental metals. Sensitive and selective detection of target molecules, such as biomarkers in various biological samples, can be obtained using various methods, such as in-situ chromogenic immunohistochemical (IHC) detection with bright field light microscopy.
    Type: Grant
    Filed: March 4, 2008
    Date of Patent: February 15, 2011
    Assignee: Nanoprobes, Inc.
    Inventors: James F. Hainfeld, Wenqiu Liu, Richard D. Powell, Vishwas N. Joshi
  • SITE-SPECIFIC ENZYMATIC DEPOSITION OF METAL IN SITU
    Publication number: 20100221727
    Abstract: The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to linking of metals to enzyme substrates, control of enzymatic metal deposition and applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.
    Type: Application
    Filed: February 17, 2010
    Publication date: September 2, 2010
    Inventors: JAMES F. HAINFELD, Wenqiu Liu
  • Method for detecting a target molecule by metal deposition
    Patent number: 7691598
    Abstract: The present invention provides methods for the use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.
    Type: Grant
    Filed: March 5, 2007
    Date of Patent: April 6, 2010
    Assignee: Nanoprobes, Inc.
    Inventors: James F. Hainfeld, Wenqiu Liu
  • SITE-SPECIFIC ENZYMATIC DEPOSITION OF METAL IN SITU
    Publication number: 20080213783
    Abstract: The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to linking of metals to enzyme substrates, control of enzymatic metal deposition and applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.
    Type: Application
    Filed: March 4, 2008
    Publication date: September 4, 2008
    Inventors: James F. Hainfeld, Wenqiu Liu
  • Site-specific enzymatic deposition of metal in situ
    Publication number: 20070224625
    Abstract: The present invention provides compositions, kits, assembles of articles and methodology for carrying out processes that permit biological enzymes to act directly on metals and metal particles. In particular, the invention relates to use of enzymes to selectively deposit metal to the vicinity of a target molecule. The invention also relates to linking of metals to enzyme substrates, control of enzymatic metal deposition and applications of enzymatic metal deposition to sensitively and selectively detect target molecules such as biomarkers in various biological samples, such as chromogenic immunohistochemical (IHC) detection in situ by using bright field light microscope.
    Type: Application
    Filed: March 5, 2007
    Publication date: September 27, 2007
    Inventors: James Hainfeld, Wenqiu Liu