Patents by Inventor Wenrun Ye

Wenrun Ye has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of purifying a salt, sodium salt and disodium salt of pemetrexed
    Patent number: 8686140
    Abstract: A method of purifying a salt of pemetrexed having a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: April 1, 2014
    Assignee: Chongqing Pharmaceutical Research Institute Co., Ltd.
    Inventors: Jie Luo, Meng Lin, Bo Lin, Wenrun Ye, Yongmei Qin, Jie Deng
  • Morphinan derivatives and preparation methods thereof
    Patent number: 8563721
    Abstract: The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.
    Type: Grant
    Filed: June 19, 2009
    Date of Patent: October 22, 2013
    Assignee: Chongqing Pharmaceutical Research Institute Co., Ltd.
    Inventors: Huafu Sun, Jie Luo, Wenrun Ye, Jie Deng, Bo Lin, Chunyan Dan, Bin Fan
  • Crystalline forms of Pemetrexed diacid, and preparations thereof
    Patent number: 8324382
    Abstract: Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof are disclosed. These preparation processes are simple and have better practicality.
    Type: Grant
    Filed: September 21, 2009
    Date of Patent: December 4, 2012
    Assignee: Chongqing Pharmaceutical Research Institute Co., Ltd.
    Inventors: Jie Luo, Meng Lin, Zhengyong Zhu, Junlai Luo, Wenrun Ye, Yongmei Qin, Jie Deng
  • HIGH-PURITY FEBUXOSTAT AND THE METHOD FOR PREPARATION
    Publication number: 20110282069
    Abstract: A febuxostat which purity is not less than 99.0%, method for preparation thereof, and pharmaceutical composition thereof. The method for preparation includes recrystallizing febuxostat in a mixed solvent. The said pharmaceutical composition can be used in manufacture of medicaments for treating diseases associated with hyperuricemia.
    Type: Application
    Filed: January 20, 2010
    Publication date: November 17, 2011
    Applicant: CHONGQING PHARMACEUTICAL RESEARCH INSTITUTE CO/. LTD.
    Inventors: Xingguo Zhou, Xuemin Tang, Ruina Shi, Wenrun Ye, Jie Luo, Jie Deng, Bin Fan
  • NEW CRYSTALLINE FORMS OF PEMETREXED DIACID, AND PREPARATIONS THEREOF
    Publication number: 20110172424
    Abstract: Three new crystalline forms of pemetrexed diacid, preparation methods and uses thereof are disclosed. These preparation processes are simple and have better practicality.
    Type: Application
    Filed: September 21, 2009
    Publication date: July 14, 2011
    Applicant: Chongqing Pharmaceutical Research Institute Co., LTD.
    Inventors: Jie Luo, Meng Lin, Zhengyong Zhu, Junlai Luo, Wenrun Ye, Yongmei Qin, Jie Deng
  • MORPHINAN DERIVATIVES AND PREPARATION METHODS THEREOF
    Publication number: 20110112297
    Abstract: The present invention relates to morphinan derivatives and preparation methods thereof, especially to ketal hydroxyl protected compounds of morphinan derivatives and preparation method thereof, and to a method for preparing corresponding alkylated morphinan derivatives by using the ketal hydroxyl protected compounds as intermediates, and more especially to a ketal hydroxyl protected compound of methylnaltrexone as intermediate for preparing methylnaltrexone and a method for preparing methylnaltrexone through said intermediate.
    Type: Application
    Filed: June 19, 2009
    Publication date: May 12, 2011
    Applicant: Chongqing Pharmaceutical Research Institute Co., Ltd.
    Inventors: Huafu Sun, Jie Luo, Wenrun Ye, Jie Deng, Bo Lin, Chunyan Dan, Bin Fan
  • METHOD OF PURIFYING A SALT, SODIUM SALT AND DISODIUM SALT OF PEMETREXED
    Publication number: 20100305319
    Abstract: A method of purifying a salt of pemetrexed have a structure of formula (III) by salting-out, wherein if M3+ is H+, then each of M1+ and M2+ is independently H+, Li+, Na+ or K+, provided that both of them are not H+; if M3+ is Li+, Na+ or K+, then each of M1+ and M2+ is independently Li+, Na+ or K+.
    Type: Application
    Filed: October 21, 2008
    Publication date: December 2, 2010
    Applicant: Chongquing Pharmaceutical Research Institute Co. ltd
    Inventors: Jie Luo, Meng Lin, Bo Lin, Wenrun Ye, Yongmei Qin, Jie Deng