Patents by Inventor Wen-sen Li

Wen-sen Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for preparing isobenzofuran-1(3H)-one compound
    Patent number: 9884835
    Abstract: A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification.
    Type: Grant
    Filed: October 14, 2015
    Date of Patent: February 6, 2018
    Assignee: EVERFRONT BIOTECH INC.
    Inventor: Wen-Sen Li
  • Method for Preparing Isobenzofuran-1(3H)-One Compound
    Publication number: 20170260155
    Abstract: A method for preparing an isobenzofuran-1(3H)-one based compound of the following formula I is provided. R1, R2 and p are defined in the specification.
    Type: Application
    Filed: October 14, 2015
    Publication date: September 14, 2017
    Inventor: Wen-Sen LI
  • ?-Lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 7176326
    Abstract: Novel ?-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling ?-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: October 20, 2004
    Date of Patent: February 13, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Method for the preparation of fused heterocyclic succinimide compounds and analogs thereof
    Patent number: 6953679
    Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
    Type: Grant
    Filed: December 19, 2001
    Date of Patent: October 11, 2005
    Assignee: Bristol-Myers Squibb Company
    Inventors: Mark E. Salvati, Toomas Mitt, Ramesh N. Patel, Ronald L. Hanson, David Brzozowski, Animesh Goswami, Linda Nga Hoong Chu, Wen-sen Li, James H. Simpson, Michael J. Totleben, Weixuan He
  • METHOD FOR THE PREPARATION OF FUSED HETEROCYCLIC SUCCINIMIDE COMPOUNDS AND ANALOGS THEREOF
    Publication number: 20050119228
    Abstract: Fused cyclic compounds, methods of using such compounds in the treatment of nuclear hormone receptor-associated conditions such as cancer and immune disorders, and pharmaceutical compositions containing such compounds.
    Type: Application
    Filed: December 19, 2001
    Publication date: June 2, 2005
    Inventors: Mark Salvati, Toomas Mitt, Ramesh Patel, Ronald Hanson, David Brzozowski, Animesh Goswami, Linda Chu, Wen-sen Li, James Simpson, Michael Totleben, Weixuan He
  • Novel beta-lactams methods for the preparation of taxanes, and sidechain-bearing taxanes
    Publication number: 20050107605
    Abstract: Novel ?-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling ?-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Application
    Filed: October 20, 2004
    Publication date: May 19, 2005
    Inventors: John Thottathil, Ivan Trifunovich, David Kucera, Wen-Sen Li
  • Process for the preparation of epothilone analogs
    Patent number: 6518421
    Abstract: The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
    Type: Grant
    Filed: February 1, 2001
    Date of Patent: February 11, 2003
    Assignee: Bristol-Myers Squibb Company
    Inventors: Wen Sen Li, John E. Thornton, Zhenrong Guo, Shankar Swaminathan
  • Process for the preparation of epothilone analogs
    Publication number: 20030004338
    Abstract: The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
    Type: Application
    Filed: September 5, 2001
    Publication date: January 2, 2003
    Inventors: Wen Sen Li, John E. Thornton, Zhenrong Guo, Shankar Swaminathan
  • Substituted alkylketo compounds and process
    Patent number: 6486331
    Abstract: Substituted alkylketo compounds of the formula can be converted to the corresponding amino acid by a stereoselective enzymatic process. The resulting amino acid compounds can be employed as starting materials for pharmaceutically active compounds. This invention is directed to the substituted alkylketo compounds and their method of preparation.
    Type: Grant
    Filed: May 3, 2001
    Date of Patent: November 26, 2002
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Ronald L. Hanson, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, John J. Venit
  • Stereoselective reductive amination of ketones
    Patent number: 6468781
    Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
    Type: Grant
    Filed: February 22, 2000
    Date of Patent: October 22, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald Hanson, Mary Jo Donovan, Steven Goldberg, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, Laszlo J. Szarka, John J. Venit
  • Novel beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Publication number: 20020137927
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Application
    Filed: December 5, 2001
    Publication date: September 26, 2002
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • Phosphonooxymethyl ethers of taxane derivatives
    Patent number: 6455575
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Grant
    Filed: June 6, 1997
    Date of Patent: September 24, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: Jerzy Golik, Dolatrai Vyas, John J. Wright, Henry Wong, John F. Kadow, John K. Thottathil, Wen-Sen Li, Murray A. Kaplan, Robert K. Perrone, Mark D. Wittman
  • Substituted alkylketo compounds and process
    Publication number: 20020049342
    Abstract: Substituted alkylketo compounds of the formula 1
    Type: Application
    Filed: May 3, 2001
    Publication date: April 25, 2002
    Inventors: Ronald L. Hanson, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, John J. Venit
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6350886
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6350887
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxanes such as taxol and taxol derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxanes, and to novel sidechain-bearing taxanes.
    Type: Grant
    Filed: May 12, 1995
    Date of Patent: February 26, 2002
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • &bgr;-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes
    Patent number: 6310201
    Abstract: Novel &bgr;-lactams finding utility as intermediates in the preparation of sidechain-bearing taxes such as tall and tall derivatives. The present invention also relates to novel methods of coupling &bgr;-lactams to form such sidechain-bearing taxes, and to novel sidechain-bearing taxes.
    Type: Grant
    Filed: June 11, 1999
    Date of Patent: October 30, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: John K. Thottathil, Ivan D. Trifunovich, David J. Kucera, Wen-Sen Li
  • PHOSPHONOOXYMETHYL ETHERS OF TAXANE DERIVATIVES
    Publication number: 20010023255
    Abstract: The present invention concerns antitumor compounds. More particularly, the invention provides novel taxane derivatives, pharmaceutical compositions thereof, and their use as antitumor agents.
    Type: Application
    Filed: June 6, 1997
    Publication date: September 20, 2001
    Inventors: JERZY GOLIK, DOLATRAI VYAS, JOHN J. WRIGHT, HENRY WONG, JOHN F. KADOW, JOHN K. THOTTATHIL, WEN-SEN LI, MURRAY A. KAPLAN, ROBERT K. PERRONE, MARK D. WITTMAN
  • Stereoselective reductive amination of ketones
    Patent number: 6140088
    Abstract: Processes for stereoselective enzymatic conversion of certain keto carboxylic acid derivatives to form the corresponding alkylamino acid compounds are described. The invention also concerns an engineered yeast host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase, as well as an engineered host cell containing recombinant nucleic acid capable of expressing a phenylalanine dehydrogenase enzyme and nucleic acid capable of expressing a formate dehydrogenase enzyme.
    Type: Grant
    Filed: July 8, 1999
    Date of Patent: October 31, 2000
    Assignee: Bristol-Myers Squibb Company
    Inventors: Ronald Hanson, Mary Jo Donovan, Steven Goldberg, Paul A. Jass, Wen-Sen Li, Ramesh Patel, Keith Ramig, Laszlo J. Szarka, John J. Venit
  • Reduction and resolution methods for the preparation of compounds useful as intermediates for preparing taxanes
    Patent number: 5817867
    Abstract: Reduction and resolution methods for the preparation of compounds useful as intermediates in the preparation of taxanes, and particularly for preparation of desired stereoisomers for use in the formation of the C-13 sidechain of pharmaceutically useful taxanes such as paclitaxel.
    Type: Grant
    Filed: November 1, 1996
    Date of Patent: October 6, 1998
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Wen-Sen Li, John K. Thottathil
  • Process for the preparation of epothilone analogs
    Patent number: RE39356
    Abstract: The present invention relates to a process for the preparation of epothilone analogs by initially forming novel ring-opened epothilones and carrying out a macrolactamization reaction thereon. The subject process is amenable to being carried out in a single reaction vessel without isolation of the intermediate compound and provides at least about a three-fold increase in yield over prior processes for preparing the desired epothilone analogs.
    Type: Grant
    Filed: February 11, 2005
    Date of Patent: October 17, 2006
    Assignee: Bristol-Myers Squibb Co.
    Inventors: Wen Sen Li, John E. Thornton, Zhenrong Guo, Shankar Swaminathan, Robert M. Borzilleri, Soong-Hoon Kim, Denis Favreau