Patents by Inventor Wenting ZHENG

Wenting ZHENG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and compositions for treating CD33+ cancers and improving in vivo persistence of chimeric antigen receptor T cells
    Patent number: 12053490
    Abstract: The application relates to a chimeric receptor that targets CD33 and allows activation of the co-stimulatory pathway without binding the natural ligand. The application also relates to polynucleotides that encode the chimeric receptor, vectors, and host cells comprising the chimeric receptor. The application also relates to methods for preparing host cells comprising a chimeric antigen receptor in order to improve the in vivo persistence of the chimeric antigen receptor host cells.
    Type: Grant
    Filed: October 25, 2018
    Date of Patent: August 6, 2024
    Assignee: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
    Inventors: Terrence L. Geiger, Wenting Zheng, Carol E. O'Hear
  • GENE KNOCK-OUTS TO IMPROVE T CELL FUNCTION
    Publication number: 20220226380
    Abstract: The present application provides methods of enhancing T cell function (e.g., expansion, persistence and/or effector functions), particularly by genetic modification of the Regnase-1, Batf, and additional genes (alone or in combination). The application also provides modified T cells manufactured using the methods provided by this invention and related pharmaceutical compositions. The application further provides methods of using the modified T cells for treating a disease (e.g., a cancer or an infectious disease).
    Type: Application
    Filed: April 23, 2020
    Publication date: July 21, 2022
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL, INC.
    Inventors: Hongbo CHI, Jun WEI, Terrence GEIGER, Wenting ZHENG