Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.

Abstract: TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer.

Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

Abstract: Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as ROR?t modulators that have a formula represented by the following: and wherein n1, n2, R1, R2, R3, and R4 are as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Abstract: The present invention relates to compounds of formula P-1 and related compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The definitions of A, Y, R1, R2, Ra, Ra?, Rb, Rb?, Rc, Rc?, Rd, Rd?, Re, and Re? are provided herein. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.

Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein Cy1, Cy2, n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to a drug-eluting stent comprising said compounds and methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.

Abstract: Provided herein are PAK inhibitors and methods of utilizing PAK inhibitors for the treatment of Fragile X syndrome.

Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

Abstract: The present invention relates to compounds and compositions useful for inhibiting and/or reducing platelet deposition, adhesion and/or aggregation. The present invention further relates to methods for the treatment or prophylaxis of thrombotic disorders, including stroke, myocardial infarction, unstable angina, peripheral vascular disease, abrupt closure following angioplasty or stent placement and thrombosis as a result of vascular surgery.

Abstract: Amido compounds are disclosed that have a formula represented by the following: and wherein n1, n2, R1a, R1b, R2, R3, R4, R5, and R6 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Abstract: Heterocyclic compounds, and pharmaceutical compositions thereof, are disclosed as ROR?t modulators that have a formula represented by the following: and wherein n1, n2, R1, R2, R3, and R4 are as described herein. These compounds may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, inflammatory conditions, autoimmune disorders, cancer, and graft-versus-host disease.

Abstract: The present invention is directed to methods of inhibiting a tauopathy in a patient by administration of a compound of formula I: Novel aminothienopyridazine compounds are also described.

Abstract: TSHR inverse agonists and neutral antagonists that are useful for treating Graves' orbitopathy, Graves' hyperthyroidism and/or thyroid cancer.

Abstract: Disclosed are oxo-hydroquinazolines that are useful as selective TSHR agonists. The compounds may be used for detecting or treating thyroid cancer, or treating a bone degenerative disorder.

Abstract: This invention relates to a method of speed control selection for an electronically commutated motor comprising the following steps: (a) a motor controller receives an input signal T from a speed control selection circuit; (b) the motor controller retrieves a corresponding value for a motor running speed S from a comparison list correlating the input signal with the motor running speed, which list has been stored in the motor controller in advance, by searching the comparison list for the input signal T; and (c) the motor controller controlling a motor M to run at the motor running speed S, achieving the purpose of the speed selection. This method allows for from 2 to 256 speed choices with a single signal wire only. Such a circuit structure has the advantages of high integration, simple wiring, low cost, good performances, low failure rate, higher number of optional speeds, and simpler and more practical control.

Abstract: The invention teaches a speed control system for a brushless DC motor for a ceiling fan, comprising a power circuit 1, a microprocessor circuit 2, a power drive circuit 3, a speed regulation circuit, and a brushless DC permanent magnetic motor 5, wherein the input terminal of the power circuit 1 is connected to the output terminal 101 of an AC power source, the output terminal of the power circuit 1 serves to power the various circuits, the output terminal of the microprocessor circuit 2 is connected to the input terminal of the power drive circuit 3, the output terminal of the power drive circuit 3 is connected to the coil windings 501 of the brushless DC permanent magnetic motor, and the output terminal of the speed regulation circuit is connected to the input terminal of the microprocessor circuit 2. The speed control system of the invention provides the advantages of low energy consumption, low noise during the operation of the motor, and a stable operation at low speeds.

Abstract: The invention teaches a ceiling fan motor, and specifically, a brushless DC external rotor motor, comprising an electrical control member and a motor structural member, wherein the motor structural member comprises a shaft 1, a stator 2, and a rotator 3, the stator is fit over the shaft 1, the rotator is fit over the stator 2, and the stator 3 is engaged with the shaft 1 via a pair of bearings 4. The rotator 3 comprises a top end cover 5, a bottom end cover 6, an outer shell cover ring 7, and a plurality of magnets 8, wherein the magnets 8 are positioned along the circumferential direction of the inner wall of the outer shell cover ring 7. The top end cover 5 and the bottom end cover 6 are installed on the top and bottom of the cover ring 7, respectively, and are connected to each other by means of a plurality of bolts and nuts. The ceiling fan motor of the invention provides the advantages of efficient energy consumption, low noise, and high operational stability at low speeds.