Abstract: Disclosed is an oral sustained-release composition for an insoluble drug, which is especially suitable for a low-dose insoluble drug, the oral sustained-release composition comprises a sustained-release granule part and a gel skeleton part, the sustained-release granule part comprises the insoluble drug, an enteric material, and a strong liquid sorbent, and the gel skeleton part comprises a hydrophilic gel skeleton material; and the sustained-release granules are obtained by preparing the insoluble drug and the enteric material into a suspension and then spraying the suspension onto the strong liquid sorbent, the sustained-release granules are wrapped by the gel skeleton to form a multiple sustained-release system technology, which prolongs a release time, and has a simple preparation process, high efficiency, uniform drug mixing, and less content loss.