Patents by Inventor Wenwu Zhai

Wenwu Zhai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies for Botulinum Neurotoxins
    Publication number: 20160229921
    Abstract: The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
    Type: Application
    Filed: December 11, 2015
    Publication date: August 11, 2016
    Inventors: James D. Marks, Yongfeng Fan, Jianlong Lou, Maria Consuelo Garcia Rodriguez, Shude Yan, Isin Nergiz Geren, Wenwu Zhai, Subhendu Chakraborti
  • ANTI-INTERLEUKIN-33 ANTIBODIES AND USES THEREOF
    Publication number: 20160168242
    Abstract: The invention provides interleukin-33 (IL-33) antibodies and methods of using the same.
    Type: Application
    Filed: November 10, 2015
    Publication date: June 16, 2016
    Inventors: Philip E. HASS, Meredith HAZEN, Yi-Chun HSIAO, Rajita KHOSLA, Gerald R. NAKAMURA, Dhaya SESHASAYEE, Menno VAN LOOKEREN CAMPAGNE, Hongkang XI, Wenwu ZHAI, Jack BEVERS, III, Nancy CHIANG
  • Method of treating type 1 diabetes with antagonist IL-7 receptor antibodies
    Patent number: 9346885
    Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
    Type: Grant
    Filed: December 17, 2013
    Date of Patent: May 24, 2016
    Assignee: Rinat Neuroscience Corp.
    Inventors: Chia-Yang Lin, Li-Fen Lee, Wenwu Zhai
  • Antibodies for Botulinum Neurotoxins
    Publication number: 20150030600
    Abstract: The present disclosure provides antibodies that specifically bind to botulinum neurotoxins (e.g., BoNT/A, BoNT/B, BoNT/C, BoNT/D, BoNT/E, BoNT/F, BoNT/G, etc.) and the epitopes bound by those antibodies. The antibodies and derivatives thereof that specifically bind to the neutralizing epitopes provided herein can be used to neutralize botulinum neurotoxin and are therefore also useful in the treatment of botulism.
    Type: Application
    Filed: August 31, 2011
    Publication date: January 29, 2015
    Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: James D. Marks, Yongfeng Fan, Jianlong Lou, Maria Consuelo Garcia Rodriguez, Shude Yan, Isin Nergiz Geren, Wenwu Zhai, Subhendu Chakraborti
  • ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS
    Publication number: 20140141018
    Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
    Type: Application
    Filed: December 17, 2013
    Publication date: May 22, 2014
    Applicant: Rinat Neuroscience Corp.
    Inventors: Chia-Yang LIN, Li-Fen LEE, Wenwu ZHAI
  • specific antibodies and uses thereof
    Patent number: 8715673
    Abstract: The present invention provides antagonizing antibodies that bind to S. aureus alpha-toxin. The invention further provides a method of obtaining such antibodies and antibody encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies for the treatment and/or prevention of staphylococcal disease, including, for example, pneumonia, bacteremia, sepsis, eye infection, and abscess.
    Type: Grant
    Filed: December 18, 2012
    Date of Patent: May 6, 2014
    Assignee: Rinat Neuroscience Corp.
    Inventors: Davide Luciano Foletti, Javier Fernando Chaparro Riggers, Jacob Eli Gunn Glanville, Lee Mary Beth Shaughnessy, David Louis Shelton, Pavel Strop, Wenwu Zhai
  • Nucleic acid encoding IL-7 receptor alpha antibody
    Patent number: 8637273
    Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: January 28, 2014
    Assignee: Rinat Neuroscience Corp.
    Inventors: Chia-Yang Lin, Li-Fen Lee, Wenwu Zhai
  • Anti-IL-7 receptor antibodies
    Patent number: 8298535
    Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
    Type: Grant
    Filed: February 23, 2011
    Date of Patent: October 30, 2012
    Assignee: Rinat Neuroscience Corp.
    Inventors: Chia-Yang Lin, Li-Fen Lee, Wenwu Zhai
  • ANTAGONIST ANTI-IL-7 RECEPTOR ANTIBODIES AND METHODS
    Publication number: 20110206698
    Abstract: The present invention provides antagonizing antibodies that bind to interleukin-7 receptor (IL-7R). The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acids. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof for the treatment and/or prevention of type 2 diabetes and immunological disorders, including type 1 diabetes, multiple sclerosis, rheumatoid arthritis, graft-versus-host disease, and lupus.
    Type: Application
    Filed: February 23, 2011
    Publication date: August 25, 2011
    Inventors: Chia-Yang Lin, Li-Fen Lee, Wenwu Zhai
  • AGONIST ANTI-TRKB MONOCLONAL ANTIBODIES
    Publication number: 20100196390
    Abstract: The present invention provides TrkB agonist antibodies. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to improve nerve function, including treatment of peripheral neuropathies, such as Charcot-Marie-Tooth disease.
    Type: Application
    Filed: February 1, 2010
    Publication date: August 5, 2010
    Inventors: Chia-Yang Lin, Javier Fernando Chaparro Riggers, Ruslan Nikolaevich Grishanin, Jennifer Renee Stratton, Wenwu Zhai