Patents by Inventor Wenxi Huang
Wenxi Huang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11011603Abstract: Semiconductor nanocrystals prepared using a mixture of organic ligands (e.g., oxoacids), as well as compositions, kits, and methods of using such semiconductor nanocrystals are disclosed.Type: GrantFiled: August 21, 2018Date of Patent: May 18, 2021Assignee: Life Technologies CorporationInventors: Joseph Bartel, Yongfen Chen, Noah Lermer, Timothy Carter, Scott Sweeney, Chad Teters, Wenxi Huang
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Publication number: 20210063415Abstract: Applications of antibodies to MYO5A protein as a biomarker in terms of determining antiphospholipid syndrome. Antibodies to the MYO5A protein include at least one of IgG, IgM or IgA. It can be used to identify primary and secondary antiphospholipid syndrome. At the same time, a reagent kit is provided, which is made of MYO5A protein, to determine whether there is antiphospholipid syndrome by detecting the presence of antibodies to MYO5A protein. The present disclosure, applications of antibodies to MYO5A protein as a biomarker in terms of determining antiphospholipid syndrome, provides a new biomarker to identify antiphospholipid syndrome and a new application direction which is of great significance for the identification of antiphospholipid syndrome.Type: ApplicationFiled: July 10, 2018Publication date: March 4, 2021Inventors: Chengde YANG, Hui SHI, Wenxi HUANG
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Publication number: 20190074354Abstract: Semiconductor nanocrystals prepared using a mixture of organic ligands (e.g., oxoacids), as well as compositions, kits, and methods of using such semiconductor nanocrystals are disclosed.Type: ApplicationFiled: August 21, 2018Publication date: March 7, 2019Inventors: Joseph Bartel, Yongfen Chen, Noah Lermer, Timothy Carter, Scott Sweeney, Chad Teters, Wenxi Huang
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Patent number: 10224398Abstract: Semiconductor nanocrystals prepared using a mixture of organic ligands (e.g., oxoacids), as well as compositions, kits, and methods of using such semiconductor nanocrystals are disclosed.Type: GrantFiled: December 23, 2011Date of Patent: March 5, 2019Assignee: Life Technologies CorporationInventors: Joseph Bartel, Yongfen Chen, Noah Lermer, Timothy Carter, Scott Sweeney, Chad Teters, Wenxi Huang
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Publication number: 20130295586Abstract: Semiconductor nanocrystals prepared using a mixture of organic ligands (e.g., oxoacids), as well as compositions, kits, and methods of using such semiconductor nanocrystals are disclosed.Type: ApplicationFiled: December 23, 2011Publication date: November 7, 2013Applicant: LIFE TECHNOLOGIES CORPORATIONInventors: Joseph August Bartel, Yongfen Chen, Noah Lermer, Timothy Carter, Scott Sweeney, Chad Teters, Wenxi Huang
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Publication number: 20110226995Abstract: This disclosure provides novel ways to modify/functionalize, including crosslink, ligands in the surface coating or molecules in other coatings on a nanoparticle, by using radical addition reactions to add a reactant group onto a ligand/molecule of a nanoparticle. Examples include using a functionalized benzophenone that can be attached or crosslinked to a ligand in the surface coating of a nanocrystal by photochemically-initiated radical addition.Type: ApplicationFiled: October 2, 2009Publication date: September 22, 2011Applicant: Life Technologies CorporationInventors: Eric Tulsky, Wenxi Huang, James Goodwin, Weiwen Zhao
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Publication number: 20070082019Abstract: A hydrogel layer is applied to a substrate advantageously when the layer is formed in situ, using a polymeric or copolymeric precursor that includes, respectively, monomer subunits that have a photocrosslinkable functionality and monomer subunits that have a chemically selective functionality for binding a biomolecular analyte, such as a protein. A hydrogel-coated substrate thus obtained is particularly useful as a probe for mass spectroscopic analysis, including SELDI analysis. Hydrogel particles also can be used for SELDI analysis.Type: ApplicationFiled: February 20, 2004Publication date: April 12, 2007Inventors: Wenxi Huang, Yury Agroskin, Egisto Boschetti
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Publication number: 20070077596Abstract: The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions, methods of using the device to detect, quantify and identify analytes, and a method of preparing a device of the invention. The luminescent moiety provides a detectable tracer that allows for a rapid, simple quality control assay of devices that incorporate the polymer.Type: ApplicationFiled: August 21, 2006Publication date: April 5, 2007Inventors: Arkadi Krainev, Wenxi Huang, Charanjit Saini
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Publication number: 20060292701Abstract: Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.Type: ApplicationFiled: April 20, 2006Publication date: December 28, 2006Inventors: Wenxi Huang, Pil-je Um
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Publication number: 20060252159Abstract: Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.Type: ApplicationFiled: April 20, 2006Publication date: November 9, 2006Inventors: Wenxi Huang, Pil-Je Um
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Publication number: 20060183242Abstract: Polymers bearing metal chelating groups are readily prepared from easily accessible precursors. The polymers are readily converted to the corresponding metal chelates. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.Type: ApplicationFiled: February 14, 2005Publication date: August 17, 2006Applicant: Ciphergen Biosystems, Inc.Inventors: Wenxi Huang, Aaron Chen, Sarah Ngola, Kamen Voivodov
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Publication number: 20060183863Abstract: Zwitterionic polymers bearing positive and negative charges are readily prepared from easily accessible precursors. The polymers show enhanced binding affinities for analytes under high salt conditions, compared to similar polymers bearing a charge of a single polarity. The polymers can also include an energy absorbing moiety for use in matrix assisted laser desorption/ionization mass spectrometry. The polymer can also include a photo-curable group, which can be used to form cross-links within the bulk polymer or between the polymer and a surface functionalized with a polymerizable moiety. The polymers are incorporated into devices of use for the analysis, capture, separation, or purification of an analyte. In an exemplary embodiment, the invention provides a substrate coated with a polymer of the invention, the substrate being adapted for use as a probe for a mass spectrometer.Type: ApplicationFiled: February 14, 2005Publication date: August 17, 2006Applicant: Ciphergen Biosystems, Inc.Inventors: Wenxi Huang, Sarah Ngola, Kamen Voivodov
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Patent number: 7045366Abstract: Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.Type: GrantFiled: March 17, 2004Date of Patent: May 16, 2006Assignee: Ciphergen Biosystems, Inc.Inventors: Wenxi Huang, Pil-je Um
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Publication number: 20050059086Abstract: Hydrogel polymer blends including precursors and crosslinked forms of the compositions. The blends provide an improved approach to achieve high quality, uniform coatings with better commercial viability than other approaches including copolymerization. Applications include mass spectral analysis of biomolecular analytes such as proteins. Dextran and acrylamide systems are preferred. Benzophenone groups can be used as photocrosslinking groups. Photoinitiators are not needed. Functionalities which can selectively bind to biomolecular analytes are included.Type: ApplicationFiled: March 17, 2004Publication date: March 17, 2005Inventors: Wenxi Huang, Pil-je Um
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Publication number: 20050013733Abstract: The present invention provides a polymer that includes a trace amount of a luminescent moiety. The polymers have unique properties that make them ideally suited for use in diverse analyses, including desorption/ionization mass spectrometry of analytes. The invention also provides a device that incorporates the polymeric compositions of the inventions, methods of using the device to detect, quantify and identify analytes, and a method of preparing a device of the invention. The luminescent moiety provides a detectable tracer that allows for a rapid, simple quality control assay of devices that incorporate the polymer.Type: ApplicationFiled: May 21, 2004Publication date: January 20, 2005Applicant: Ciphergen Biosystems, Inc.Inventors: Arkadi Krainev, Wenxi Huang, Charanjit Saini
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Patent number: 6054554Abstract: The invention herein relates to a novel soluble polyimide resin comprising polyalicyclic structures and the process of preparation of the same, wherein aromatic tetracarboxylic dianhydride and novel aromatic diamine having an polyalicyclic group with various structures are used to yield a novel form of a polyimide resin, which has superior heat-resistance, solubility, and transparency.More specifically, the invention herein relates to a novel polyimide resin having excellent heat-resistance and solubility, which is prepared by means of reacting diamine monomers having a novel chemical structure with various types of aromatic carboxilic dianhydrides, in stead of aromatic diamine used for the preparation of the conventional polyimide resin. As a result, the polymers so obtained had the glass transition temperature of 260.degree. C..about.410.degree. C. and showed a increase in solubility in proportion to the increase in a number of the aromatic rings between two phenyl groups.Type: GrantFiled: May 7, 1999Date of Patent: April 25, 2000Assignee: Korea Research Institute of Chemical TechnologyInventors: Kil Yeong Choi, Mi Hie Yi, Wenxi Huang
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Patent number: 6031067Abstract: The invention herein relates to a soluble polyimide resin and the process of preparation of the same, wherein aromatic tetracarboxylic dianhydride and aromatic diamine having an alicyclic group with various structures of substituted alkyl groups are used to yield a novel form of a polyimide resin, which has superior heat-resistance, solubility and transparency.More specifically, the invention herein relates to a novel polyimide resin having excellent heat-resistance and solubility, which is prepared by means of reacting aromatic diamine monomers having a novel chemical structure with various types of aromatic tetracarboxilic acid dianhydrides, in stead of aromatic diamine used for the preparation of the conventional polyimide resin. As a result, the polymers so obtained had the glass transition temperature of 250.degree. C..about.400.degree. C. and showed a increase in solubility in proportion to the increase in volume of the alkyl group.Type: GrantFiled: May 29, 1998Date of Patent: February 29, 2000Assignee: Korea Research Institute of Chemical TechnologyInventors: Kil-Yeong Choi, Mi-Hie Yi, Wenxi Huang