Patents by Inventor Wenyan Shen

Wenyan Shen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 12378312
    Abstract: The present disclosure provides binding proteins, such as antibodies or binding fragments thereof, that bind beta klotho, including human beta klotho, and methods of their use such as in producing an antibody or binding fragment thereof. The present disclosure also provides vectors and cells comprising polynucleotides encoding antibodies or binding fragments thereof that bind beta klotho, including human beta klotho.
    Type: Grant
    Filed: January 12, 2023
    Date of Patent: August 5, 2025
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Kalyani Mondal, Betty Chan Li, Yu Chen, Taruna Arora, Hugo Matern, Wenyan Shen
  • Publication number: 20250188174
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha Like (GFRAL) protein, including human GFRAL protein, and methods of their use.
    Type: Application
    Filed: November 20, 2024
    Publication date: June 12, 2025
    Inventors: Wenyan Shen, Jie Tang, Yan Wang, Hugo Matern
  • Publication number: 20250049938
    Abstract: A linker, comprising an amino acid unit (RL). The RL comprises -Val-Ala-Q-Gly-Phe-Gly-, wherein Q is a bond, a single amino acid or a dipeptide. By optimizing a polypeptide sequence, the purpose of more effectively releasing small molecule drugs in tumor cells by ADC drugs is achieved. In addition, the present invention further relates to linker drug containing the above-mentioned linker, a conjugate, and the use of the linker drug and the conjugate.
    Type: Application
    Filed: November 30, 2022
    Publication date: February 13, 2025
    Inventors: Aidong QU, Hongyuan LIANG, Wenyan SHEN, Jingye ZHU, Jianhua QIU, Xu ZHOU
  • Patent number: 12180289
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha Like (GFRAL) protein, including human GFRAL protein, and methods of their use.
    Type: Grant
    Filed: March 5, 2021
    Date of Patent: December 31, 2024
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Wenyan Shen, Jie Tang, Yan Wang, Hugo Matern
  • Patent number: 12173060
    Abstract: A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: November 7, 2022
    Date of Patent: December 24, 2024
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Wenyan Shen, Darrin Anthony Lindhout, Raj Haldankar, Hugo Matern
  • Publication number: 20240084023
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind glucagon receptors, including a human glucagon receptor, and methods of their use.
    Type: Application
    Filed: June 27, 2023
    Publication date: March 14, 2024
    Inventors: Wenyan Shen, Yan Wang, Hugo Matern, Zhonghao Liu
  • Publication number: 20230312696
    Abstract: A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Application
    Filed: November 7, 2022
    Publication date: October 5, 2023
    Inventors: Wenyan Shen, Darrin Anthony Lindhout, Raj Haldankar, Hugo Matern
  • Patent number: 11732049
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind glucagon receptors, including a human glucagon receptor, and methods of their use.
    Type: Grant
    Filed: March 19, 2021
    Date of Patent: August 22, 2023
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Wenyan Shen, Yan Wang, Hugo Matern, Zhonghao Liu
  • Publication number: 20230256070
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
    Type: Application
    Filed: January 12, 2023
    Publication date: August 17, 2023
    Inventors: Kalyani Mondal, Betty Chan Li, Yu Chen, Taruna Arora, Hugo Matern, Wenyan Shen
  • Patent number: 11667708
    Abstract: The present disclosure provides binding proteins, such as antibodies, and binding fragments thereof, that bind beta klotho, including human beta klotho, and exemplary specific sequences of their complementarity determining regions, variable regions, heavy chains, and light chains. The present disclosure also provides method of making the antibody or fragment thereof and methods of their use, including, in activating beta-klotho/FGF receptor complex, inducing FGF19-like and/or FGF21-like signaling, improving glucose and lipid metabolism, and treatment of nonalcoholic steatohepatitis.
    Type: Grant
    Filed: August 28, 2020
    Date of Patent: June 6, 2023
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Kalyani Mondal, Betty Chan Li, Yu Chen, Taruna Arora, Hugo Matern, Wenyan Shen
  • Patent number: 11596676
    Abstract: The present disclosure provides binding proteins, such as antibodies and binding fragments thereof, that bind beta klotho, including human beta klotho, and methods of their use, including in the treatment of nonalcoholic steatohepatitis. The present disclosure also provides exemplary specific sequences of complementarity determining regions, variable regions, heavy chains, and light chains of the antibodies and/or binding fragments thereof.
    Type: Grant
    Filed: July 14, 2020
    Date of Patent: March 7, 2023
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Kalyani Mondal, Betty Chan Li, Yu Chen, Taruna Arora, Hugo Matern, Wenyan Shen
  • Patent number: 11530260
    Abstract: A complex comprising a GDF15 polypeptide is described. Methods of treating individuals with a metabolism disorder, such as, glucose metabolism disorder and/or a body weight disorder, and compositions associated therewith, are provided.
    Type: Grant
    Filed: January 15, 2020
    Date of Patent: December 20, 2022
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Wenyan Shen, Darrin Anthony Lindhout, Raj Haldankar, Hugo Matern
  • Publication number: 20220073627
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha Like (GFRAL) protein, including human GFRAL protein, and methods of their use.
    Type: Application
    Filed: March 5, 2021
    Publication date: March 10, 2022
    Inventors: Wenyan Shen, Jie Tang, Yan Wang, Hugo Matern
  • Publication number: 20210332144
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind glucagon receptors, including a human glucagon receptor, and methods of their use.
    Type: Application
    Filed: March 19, 2021
    Publication date: October 28, 2021
    Inventors: Wenyan Shen, Yan Wang, Hugo Matern, Zhonghao Liu
  • Publication number: 20210253741
    Abstract: The present disclosure relates to multispecific binding agents, in particular tetravalent bispecific antibodies, related polynucleotides, vectors, host cells, compositions, and methods of producing the binding agents.
    Type: Application
    Filed: July 2, 2019
    Publication date: August 19, 2021
    Inventors: Alan Kent Kutach, Wenyan Shen, Jie Tang, Wenwu Zhai
  • Patent number: 10995145
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind glucagon receptors, including a human glucagon receptor, and methods of their use.
    Type: Grant
    Filed: January 26, 2018
    Date of Patent: May 4, 2021
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Wenyan Shen, Yan Wang, Hugo Matern, Zhonghao Liu
  • Publication number: 20210115133
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
    Type: Application
    Filed: August 28, 2020
    Publication date: April 22, 2021
    Inventors: Kalyani Mondal, Betty Chan Li, Yu Chen, Taruna Arora, Hugo Matern, Wenyan Shen
  • Patent number: 10975154
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind to a GDNF Family Receptor Alpha Like (GFRAL) protein, including human GFRAL protein, and methods of their use.
    Type: Grant
    Filed: September 12, 2018
    Date of Patent: April 13, 2021
    Assignee: NGM Biopharmaceuticals, Inc.
    Inventors: Wenyan Shen, Jie Tang, Yan Wang, Hugo Matern
  • Publication number: 20210030857
    Abstract: The present disclosure provides binding proteins, such as antibodies, that bind beta klotho, including human beta klotho, and methods of their use.
    Type: Application
    Filed: July 14, 2020
    Publication date: February 4, 2021
    Inventors: Kalyani Mondal, Betty Chan Li, Yu Chen, Taruna Arora, Hugo Matern, Wenyan Shen
  • Patent number: D1018341
    Type: Grant
    Filed: May 24, 2023
    Date of Patent: March 19, 2024
    Assignee: BAOLI TIANTONG INSTRUMENTS CORP.
    Inventor: Wenyan Shen