Abstract: Provided in the present invention is a recombinant hEGF-CRM197 tumor therapeutic vaccine formulation. Specifically, the formulation of the present invention contains a therapeutically effective amount of a conjugate of a recombinant human epidermal growth factor (hEGF) and a diphtheria toxin mutant (CRM197), a phosphate base buffer solution with the pH in a range of 7.5-8.5, a polysorbate 20 surfactant and optionally a monosaccharide or disaccharide. The protein conjugate molecule in the formulation of the present invention can break immune tolerance and induce the production of an anti-human epidermal growth factor antibody in the human body; In addition, the protein conjugate molecule produces a lower proportion of polymers, and has a more uniform molecular weight distribution in the buffer, and better stability. Therefore, the formulation of the present invention can achieve large-scale production and can be stably stored for a long time.

Abstract: Disclosed is a preparation system and a preparation method for high-quality xylitol crystals. The preparation system comprises a blending tank, a heat exchanger, a decolorization tank, an ion exchange system, a microporous filter, a first evaporator, a first crystallization kettle, a first centrifuge, a fluidization drying bed, a xylitol dissolution tank, a second evaporator, a second crystallization kettle, a second centrifuge, a hot air drying tank, and a cold air fluidization bed sequentially connected through pipelines. Liquid outlet of the first centrifuge is connected with first inlet of the blending tank. Liquid outlet of the second centrifuge is connected with first inlet of the xylitol dissolution tank. The blending tank is provided with second inlet for receiving xylitol hydrogenation solution. The xylitol dissolution tank is provided with water inlet for pure water. The material output from a product outlet of the cold air fluidization bed is xylitol crystal product.

Abstract: Disclosed is a preparation system and a preparation method for high-quality xylitol crystals. The preparation system comprises a blending tank, a heat exchanger, a decolorization tank, an ion exchange system, a microporous filter, a first evaporator, a first crystallization kettle, a first centrifuge, a fluidization drying bed, a xylitol dissolution tank, a second evaporator, a second crystallization kettle, a second centrifuge, a hot air drying tank, and a cold air fluidization bed sequentially connected through pipelines. Liquid outlet of the first centrifuge is connected with first inlet of the blending tank. Liquid outlet of the second centrifuge is connected with first inlet of the xylitol dissolution tank. The blending tank is provided with second inlet for receiving xylitol hydrogenation solution. The xylitol dissolution tank is provided with water inlet for pure water. The material output from a product outlet of the cold air fluidization bed is xylitol crystal product.

Abstract: The present disclosure discloses systems and methods for preparing compound crystals of erythritol and high-intensity sweeteners. The systems may comprise a fermentation liquid storage tank, a ceramic membrane filtration system, a nanofiltration system, a first evaporator, a first crystallization kettle, a first centrifuge, a sugar dissolution tank, a decolorization tank, an ion exchange column, a blending tank, a second evaporator, a second crystallization kettle, a second centrifuge, a hot-air drying tank, a fluidized drying bed, and a finished product tank sequentially connected through pipelines. The systems may further comprise a high-intensity sweetener storage tank, a primary mother liquor tank, and a secondary mother liquor tank. The finished product tank may store a prepared compound crystallization product of the erythritol and the high-intensity sweetener.

Abstract: The present invention relates to a sweetener liquid for preventing and relieving intestinal sugar alcohol intolerance. The sweetener liquid per 100ml includes 0.01 to 0.04 g of low-esterification pectin, 0.01 g to 0.1 g of ?-carrageenan, 0.01 g to 0.3 g of locust bean gum, 30 g to 60 g of xylitol, 5 g to 15 g of maltitol and 1 g to 10 g of sorbitol and remaining water; the low-esterification pectin is a pectin concentrate including, based on parts by weight, 15 parts of calcium citrate, 60 parts of low-molecular-weight pectin, 85 parts of ethylene glycol, 5 parts of carboxymethyl cellulose sodium and 30 parts of sodium citrate; the low-molecular-weight pectin includes a low-sugar fruit juice and a lemon juice; the sweetener liquid has a pH of 5-6.5 and a viscosity of 0.1 to 25 mPa•S. The present invention further provides a method of preparing a sweetener liquid and an application thereof.

Abstract: A fluid diverting module includes a multi-position fluid diverting device comprising three-dimensional movable flow-paths with minimal tortuosity in the movable portion (the rotor) of the fluid diverting device. In some embodiments, the device is also equipped with a filtration module that is capable of filtering solid particulates from fluidic samples. The invention relates to an area of non-disruptive sampling from various sample sources including ones containing solids. The fluid diverting device maintains fluid communication between the sample source and a pressure creating device in all positions of the fluid diverting device, thus conserving the pressure inside the sample source during sampling. The sampling operation is controlled from a controller, which is equipped with a software for manual or intelligent control.

Abstract: The present invention relates to a method for improving sensory attributes of a sugar alcohol and application thereof. After analyzing the difference between the sugar alcohol used as a sugar substitute and sucrose in multiple sensory attribute dimensions by flavor analysis, corresponding taste modifying substances are added according to the intensity of the difference, thereby solving the problem that there are differences between the sugar alcohol used as a sugar substitute and the sucrose in taste sensory attributes in the field of food at present. According to the invention, the taste difference between the sugar alcohol and the sucrose in multiple sensory attribute dimensions is analyzed, so that the level of taste improvement is broader. Multidimensional accurate quantification of differences is realized by means of a sensory flavor wheel, thereby realizing accurate taste modification and improving the accuracy of taste improvement.

Abstract: A multidimensional chromatographic assembly includes a chromatographic medium selector module, which receives a sample from an injector module and moves the sample through one of at least two chromatographic media of a chromatographic medium module using at least one eluent from at least one fluid moving module. At least a portion of the sample is re-circulated through the same or the second chromatographic medium using a multi-configuration fluid diverting module, which isolates a selected portion of the chromatographed eluent containing at least a portion of the sample in at least one fluid holding compartment and later moves the isolated portion through one of the chromatographic media in an iterative manner until all attributes of the isolated portion in question are analyzed.

Abstract: The present disclosure relates to a method for calculating a tolerated dose of a human body to sugar alcohol and functional sugar.

Abstract: A fluid diverting module includes a multi-position fluid diverting device comprising three-dimensional movable flow-paths with minimal tortuosity in the movable portion (the rotor) of the fluid diverting device. In some embodiments, the device is also equipped with a filtration module that is capable of filtering solid particulates from fluidic samples. The invention relates to an area of non-disruptive sampling from various sample sources including ones containing solids. The fluid diverting device maintains fluid communication between the sample source and a pressure creating device in all positions of the fluid diverting device, thus conserving the pressure inside the sample source during sampling. The sampling operation is controlled from a controller, which is equipped with a software for manual or intelligent control.