Patents by Inventor Wenyi Zhao

Wenyi Zhao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Heteroaryl derivatives and uses thereof
    Patent number: 9409893
    Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: August 9, 2016
    Assignee: Jacobus Pharmaceutical Company, Inc.
    Inventors: Gavin David Heffernan, David Penman Jacobus, Kurt William Saionz, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
  • SINGLE-CHIP SENSOR MULTI-FUNCTION IMAGING
    Publication number: 20160227129
    Abstract: Mixed mode imaging is implemented using a single-chip image capture sensor with a color filter array. The single-chip image capture sensor captures a frame including a first set of pixel data and a second set of pixel data. The first set of pixel data includes a first combined scene, and the second set of pixel data includes a second combined scene. The first combined scene is a first weighted combination of a fluorescence scene component and a visible scene component due to the leakage of a color filter array. The second combined scene includes a second weighted combination of the fluorescence scene component and the visible scene component. Two display scene components are extracted from the captured pixel data in the frame and presented on a display unit.
    Type: Application
    Filed: January 27, 2016
    Publication date: August 4, 2016
    Applicant: Intuitive Surgical Operations, Inc.
    Inventors: Wenyi Zhao, Jeffrey DiCarlo, Ian E. McDowall
  • Efficient 3-D telestration for local and remote robotic proctoring
    Patent number: 9402690
    Abstract: An apparatus is configured to show telestration in 3-D to a surgeon in real time. A proctor is shown one side of a stereo image pair, such that the proctor can draw a telestration line on the one side with an input device. Points of interest are identified for matching to the other side of the stereo image pair. In response to the identified points of interest, regions and features are identified and used to match the points of interest to the other side. Regions can be used to match the points of interest. Features of the first image can be matched to the second image and used to match the points of interest to the second image, for example when the confidence scores for the regions are below a threshold value. Constraints can be used to evaluate the matched points of interest, for example by excluding bad points.
    Type: Grant
    Filed: August 3, 2014
    Date of Patent: August 2, 2016
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Wenyi Zhao, Chenyu Wu, David Hirvonen, Christopher J. Hasser, Brian E. Miller, Catherine J. Mohr, Tao Zhao, Simon Di Maio, Brian D. Hoffman
  • Geometrically appropriate tool selection assistance for determined work site dimensions
    Patent number: 9375844
    Abstract: A robotic system includes a processor that is programmed to determine and cause work site measurements for user specified points in the work site to be graphically displayed in order to provide geometrically appropriate tool selection assistance to the user. The processor is also programmed to determine an optimal one of a plurality of tools of varying geometries for use at the work site and to cause graphical representations of at least the optimal tool to be displayed along with the work site measurements.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 28, 2016
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Brandon D. Itkowitz, Simon P. DiMaio, Craig R. Gerbi, Theodore W. Rogers, Wenyi Zhao
  • Aryl derivatives and uses thereof
    Patent number: 9296696
    Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: March 29, 2016
    Assignee: Jacobus Pharmaceuticals Company, Inc.
    Inventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
  • Single-chip sensor multi-function imaging
    Patent number: 9277205
    Abstract: Mixed mode imaging is implemented using a single-chip image capture sensor with a color filter array. The single-chip image capture sensor captures a frame including a first set of pixel data and a second set of pixel data. The first set of pixel data includes a first combined scene, and the second set of pixel data includes a second combined scene. The first combined scene is a first weighted combination of a fluorescence scene component and a visible scene component due to the leakage of a color filter array. The second combined scene includes a second weighted combination of the fluorescence scene component and the visible scene component. Two display scene components are extracted from the captured pixel data in the frame and presented on a display unit.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: March 1, 2016
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Wenyi Zhao, Jeffrey DiCarlo, Ian E. McDowall
  • TARGETS, FIXTURES, AND WORKFLOWS FOR CALIBRATING AN ENDOSCOPIC CAMERA
    Publication number: 20160048953
    Abstract: The present disclosure relates to calibration assemblies and methods for use with an imaging system, such as an endoscopic imaging system. A calibration assembly includes: an interface for constraining engagement with an endoscopic imaging system; a target coupled with the interface so as to be within the field of view of the imaging system, the target including multiple of markers having calibration features that include identification features; and a processor configured to identify from first and second images obtained at first and second relative spatial arrangements between the imaging system and the target, respectively, at least some of the markers from the identification features, and using the identified markers and calibration feature positions within the images to generate calibration data.
    Type: Application
    Filed: August 18, 2015
    Publication date: February 18, 2016
    Inventors: Tao Zhao, Wenyi Zhao, David D. Scott
  • Single-chip sensor multi-function imaging
    Patent number: 9258549
    Abstract: Mixed mode imaging is implemented using a single-chip image capture sensor with a color filter array. The single-chip image capture sensor captures a frame including a first set of pixel data and a second set of pixel data. The first set of pixel data includes a first combined scene, and the second set of pixel data includes a second combined scene. The first combined scene is a first weighted combination of a fluorescence scene component and a visible scene component due to the leakage of a color filter array. The second combined scene includes a second weighted combination of the fluorescence scene component and the visible scene component. Two display scene components are extracted from the captured pixel data in the frame and presented on a display unit.
    Type: Grant
    Filed: May 14, 2013
    Date of Patent: February 9, 2016
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Jeffrey DiCarlo, Ian E. McDowall, Wenyi Zhao
  • Virtual measurement tool for minimally invasive surgery
    Patent number: 9155592
    Abstract: Robotic and/or measurement devices, systems, and methods for telesurgical and other applications employ input devices operatively coupled to tools so as to allow a system user to manipulate tissues and other structures being measured. The system may make use of three dimensional position information from stereoscopic images. Two or more discrete points can be designated in three dimensions so as to provide a cumulative length along a straight or curving structure, an area measurement, a volume measurement, or the like. The discrete points may be identified by a single surgical tool or by distances separating two or more surgical tools, with the user optionally measuring a structure longer than a field of view of the stereoscopic image capture device by walking a pair of tools “hand-over-hand” along the structure.
    Type: Grant
    Filed: June 16, 2009
    Date of Patent: October 13, 2015
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Brandon D. Itkowitz, Tao Zhao, Simon Dimaio, Wenyi Zhao, Christopher J. Hasser, Myriam J. Curet, Catherine J. Mohr, Hubert Stein
  • AUGMENTED STEREOSCOPIC VISUALIZATION FOR A SURGICAL ROBOT USING A CAPTURED VISIBLE IMAGE COMBINED WITH A FLUOROESCENCE IMAGE AND A CAPTURED VISIBLE IMAGE
    Publication number: 20150077519
    Abstract: An endoscope with a stereoscopic optical channel is held and positioned by a robotic surgical system. A capture unit captures (1) a visible first image and (2) a visible second image combined with a fluorescence second image from the light. An intelligent image processing system receives (1) the visible first image and (2) the visible second image combined with the fluorescence second image and generates at least one fluorescence image of a stereoscopic pair of fluorescence images and a visible second image. An augmented stereoscopic display system outputs a real-time stereoscopic image including a three-dimensional presentation including in one eye, a blend of the at least one fluorescence image of a stereoscopic pair of fluorescence images and one of the visible first and second images; and in the other eye, the other of the visible first and second images.
    Type: Application
    Filed: July 16, 2014
    Publication date: March 19, 2015
    Inventors: David Scott, Wenyi Zhao, Brian D. Hoffman, John D. Stern, Tao Zhao
  • Aryl Derivatives And Uses Thereof
    Publication number: 20150080324
    Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
    Type: Application
    Filed: November 25, 2014
    Publication date: March 19, 2015
    Inventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
  • Efficient vision and kinematic data fusion for robotic surgical instruments and other applications
    Patent number: 8971597
    Abstract: Robotic devices, systems, and methods for use in telesurgical therapies through minimally invasive apertures make use of joint-based data throughout much of the robotic kinematic chain, but selectively rely on information from an image capture device to determine location and orientation along the linkage adjacent a pivotal center at which a shaft of the robotic surgical tool enters the patient. A bias offset may be applied to a pose (including both an orientation and a location) at the pivotal center to enhance accuracy. The bias offset may be applied as a simple rigid transformation from the image-based pivotal center pose to a joint-based pivotal center pose.
    Type: Grant
    Filed: June 30, 2009
    Date of Patent: March 3, 2015
    Assignee: Intuitive Surgical Operations, Inc.
    Inventors: Tao Zhao, Wenyi Zhao, Brian D. Hoffman, William C. Nowlin, Hua Hui
  • Aryl derivatives and uses thereof
    Patent number: 8962657
    Abstract: The present invention relates to antimalarial compounds and their use against protozoa of the genus Plasmodium, including drug-resistant Plasmodia strains. This invention further relates to compositions containing such compounds and a process for making the compounds.
    Type: Grant
    Filed: November 8, 2013
    Date of Patent: February 24, 2015
    Assignee: Jacobus Pharmaceutical Company, Inc.
    Inventors: Gavin David Heffernan, David Penman Jacobus, Guy Alan Schiehser, Hong-Ming Shieh, Wenyi Zhao
  • Efficient Image Demosaicing and Local Contrast Enhancement
    Publication number: 20150042775
    Abstract: An efficient demosaicing method includes reconstructing missing green pixels after estimating green-red color difference signals and green-blue color difference signals that are used in the reconstruction, and then constructing missing red and blue pixels using the color difference signals. This method creates a full resolution frame of red, green and blue pixels. The full resolution frame of pixels is sent to a display unit for display. In an efficient demosaicing process that includes local contrast enhancement, image contrast is enhanced to build and boost a brightness component from the green pixels, and to build chromatic components from all of the red, green, and blue pixels. Color difference signals are used in place of the red and blue pixels in building the chromatic components.
    Type: Application
    Filed: August 5, 2014
    Publication date: February 12, 2015
    Inventor: Wenyi Zhao
  • EFFICIENT 3-D TELESTRATION FOR LOCAL AND REMOTE ROBOTIC PROCTORING
    Publication number: 20150025392
    Abstract: An apparatus is configured to show telestration in 3-D to a surgeon in real time. A proctor is shown one side of a stereo image pair, such that the proctor can draw a telestration line on the one side with an input device. Points of interest are identified for matching to the other side of the stereo image pair. In response to the identified points of interest, regions and features are identified and used to match the points of interest to the other side. Regions can be used to match the points of interest. Features of the first image can be matched to the second image and used to match the points of interest to the second image, for example when the confidence scores for the regions are below a threshold value. Constraints can be used to evaluate the matched points of interest, for example by excluding bad points.
    Type: Application
    Filed: August 3, 2014
    Publication date: January 22, 2015
    Applicant: Intuitive Surgical Operations Inc.
    Inventors: WENYI ZHAO, CHENYU WU, DAVID HIRVONEN, CHRISTOPHER J. HASSER, BRIAN E. MILLER, CATHERINE J. MOHR, TAO ZHAO, SIMON DI MAIO, BRIAN D. HOFFMAN
  • METHODS OF LOCATING AND TRACKING ROBOTIC INSTRUMENTS IN ROBOTIC SURGICAL SYSTEMS
    Publication number: 20150005622
    Abstract: In one embodiment of the invention, a method is disclosed to locate a robotic instrument in the field of view of a camera. The method includes capturing sequential images in a field of view of a camera. The sequential images are correlated between successive views. The method further includes receiving a kinematic datum to provide an approximate location of the robotic instrument and then analyzing the sequential images in response to the approximate location of the robotic instrument. An additional method for robotic systems is disclosed. Further disclosed is a method for indicating tool entrance into the field of view of a camera.
    Type: Application
    Filed: June 25, 2014
    Publication date: January 1, 2015
    Inventors: Wenyi Zhao, Christopher J. Hasser, William C. Nowlin, Brian D. Hoffman
  • DEPTH BASED MODIFICATION OF CAPTURED IMAGES
    Publication number: 20140267603
    Abstract: An imaging system processes images of a plurality of objects which have been captured by an image capture device for display. Normal processing of the images is modified as either a function of a depth corresponding to one or more of the plurality of objects appearing in the captured images relative to the image capture device or as a function of the depth and one or more image characteristics extracted from the captured images. A depth threshold may be used to avoid inadvertent modifications due to noise.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Intuitive Surgical Operations, Inc.
    Inventors: AMY E. KERDOK, WENYI ZHAO
  • ROBOTIC SYSTEM PROVIDING USER SELECTABLE ACTIONS ASSOCIATED WITH GAZE TRACKING
    Publication number: 20140282196
    Abstract: A robotic system provides user selectable actions associated with gaze tracking according to user interface types. User initiated correction and/or recalibration of the gaze tracking may be performed during the processing of individual of the user selectable actions.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Intuitive Surgical Operations, Inc.
    Inventors: Wenyi Zhao, Christopher J. Hasser, Brandon D. Itkowitz, Paul E. Lilagan, David D. Scott, Paul W. Mohr, Simon P. DiMaio, David W. Robinson, Tao Zhao
  • GEOMETRICALLY APPROPRIATE TOOL SELECTION ASSISTANCE FOR DETERMINED WORK SITE DIMENSIONS
    Publication number: 20140277736
    Abstract: A robotic system includes a processor that is programmed to determine and cause work site measurements for user specified points in the work site to be graphically displayed in order to provide geometrically appropriate tool selection assistance to the user. The processor is also programmed to determine an optimal one of a plurality of tools of varying geometries for use at the work site and to cause graphical representations of at least the optimal tool to be displayed along with the work site measurements.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Intuitive Surgical Operations, Inc.
    Inventors: Brandon D. Itkowitz, Simon P. DiMaio, Craig R. Gerbi, Theodore W. Rogers, Wenyi Zhao
  • INTELLIGENT MANUAL ADJUSTMENT OF AN IMAGE CONTROL ELEMENT
    Publication number: 20140267626
    Abstract: An imaging system comprises an image capturing device, a viewer, a control element, and a processor. The control element controls or adjusts an image characteristic of one of the image capturing device and the viewer. The processor is programmed to determine a depth value relative to the image capturing device, determine a desirable adjustment to the control element by using the determined depth value, and control adjustment of the control element to assist manual adjustment of the control element to the desirable adjustment. The processor may also be programmed to determine whether the adjustment of the control element is to be automatically or manually adjusted and control adjustment of the control element automatically to the desirable adjustment if the control element is to be automatically adjusted.
    Type: Application
    Filed: March 14, 2014
    Publication date: September 18, 2014
    Applicant: Intuitive Surgical Operations, Inc.
    Inventors: Paul E. Lilagan, Wenyi Zhao