Patents by Inventor Wenying Chai

Wenying Chai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1,2,6-SUBSTITUTED BENZIMIDAZOLES AS FLAP MODULATORS
    Publication number: 20140275029
    Abstract: The present invention relates to compounds of Formula (I), and solvates, hydrates, and pharmaceutically acceptable salts thereof, wherein X1, X1?, X1?, R1, R2 and R3 are as defined herein, useful as FLAP modulators. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Inventors: Wenying Chai, Curt A. Dvorak, Wendy Eccles, James P. Edwards, Steven D. Goldberg, Paul J. Krawczuk, Alec D. Lebsack, Jing Liu, Daniel J. Pippel, Zachary S. Sales, Virginia M. Tanis, Mark S. Tichenor, John J. M. Wiener
  • DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
    Publication number: 20140179697
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: December 23, 2013
    Publication date: June 26, 2014
    Applicant: JANSSEN PHARMACEUTICA NV
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode Johnson, Emily M. Stocking, Devin M. Swanson
  • Disubstituted octahydropyrrolo[3,4-c]pyrroles as orexin receptor modulators
    Patent number: 8653263
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Grant
    Filed: October 21, 2010
    Date of Patent: February 18, 2014
    Assignee: Janssen Pharmaceutica
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode-Johnson, Emily M. Stocking, Devin M. Swanson
  • SEROTONIN RECEPTOR MODULATOR
    Publication number: 20140038943
    Abstract: Certain biphenyic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Application
    Filed: October 10, 2013
    Publication date: February 6, 2014
    Applicant: Janssen Pharmaceutica NV
    Inventors: Nicholas I. Carruthers, Wenying Chai, Jill A. Jablonowski, Chandravadan R. Shah, Brock T. Shireman, Devin M. Swanson, Vi Tran, Victoria Wong
  • Serotonin receptor modulators
    Patent number: 8642583
    Abstract: The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Grant
    Filed: October 29, 2009
    Date of Patent: February 4, 2014
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nicholas I. Carruthers, Wenying Chai, Jill A. Jablonowski, Chandravadan R. Shah, Brock T. Shireman, Devin M. Swanson, Vi T. Tran, Victoria D. Wong
  • DISUBSTITUTED OCTAHYDROPYRROLO[3,4-c]PYRROLES AS OREXIN RECEPTOR MODULATORS
    Publication number: 20120208812
    Abstract: Disubstituted octahydropyrrolo[3,4-c]pyrrole compounds are described, which are useful as orexin receptor modulators. Such compounds may be useful in pharmaceutical compositions and methods for the treatment of diseased states, disorders, and conditions mediated by orexin activity, such as insomnia.
    Type: Application
    Filed: October 21, 2010
    Publication date: August 16, 2012
    Applicant: Janssen Pharmaceutica N.V.
    Inventors: Wenying Chai, Michael A. Letavic, Kiev S. Ly, Daniel J. Pippel, Dale A. Rudolph, Kathleen C. Sappey, Brad M. Savall, Chandravadan R. Shah, Brock T. Shireman, Akinola Soyode-Johnson, Emily M. Stocking, Devin M. Swanson
  • PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
    Publication number: 20120129870
    Abstract: The present invention is directed to piperidinyl and piperazinyl derivatives of formula (II) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
    Type: Application
    Filed: December 17, 2008
    Publication date: May 24, 2012
    Inventors: Wenying Chai, Jill A. Jablonowski, Dale A. Rudolph, Chandravadan R. Shah, Devin M. Swanson, Victoria D. Wong
  • Substituted piperazines and piperidines as modulators of the neuropeptide Y2 receptor
    Patent number: 8183239
    Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
    Type: Grant
    Filed: October 27, 2006
    Date of Patent: May 22, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Pascal Bonaventure, Nicholas I. Carruthers, Wenying Chai, Curt A. Dvorak, Jill A. Jablonowski, Dale A. Rudolph, Mark Seierstad, Chandravadan R. Shah, Devin M. Swanson, Victoria D. Wong
  • PIPERAZINYL DERIVATIVES USEFUL AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
    Publication number: 20120015957
    Abstract: The present invention is directed to piperidinyl and piperazinyl derivatives of formula (I) useful as inhibitors of the NPY Y2 receptor, pharmaceutical compositions comprising said compounds, processes for the preparation of said compounds and the use of said compounds for the treatment and/or prevention of disorders, diseases and conditions mediated by the NPY Y2 receptor.
    Type: Application
    Filed: December 17, 2008
    Publication date: January 19, 2012
    Inventors: Wenying Chai, Curt A. Dvorak, Jill A. Jablonowski, Dale A. Rudolph, Chandravadan R. Shah, Victoria D. Wong
  • SEROTONIN RECEPTOR MODULATORS
    Publication number: 20110207714
    Abstract: The biphenyic compounds of formula (I) are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Application
    Filed: October 29, 2009
    Publication date: August 25, 2011
    Inventors: Nicholas I. Carruthers, Brock T. Shireman, Vi T. Tran, Victoria D. Wong, Jill A. Jablonowski, Wenying Chai
  • Fused heterocyclic compounds
    Patent number: 7897771
    Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Grant
    Filed: July 2, 2009
    Date of Patent: March 1, 2011
    Assignee: Janssen Pharmaceutica NV
    Inventors: Nicholas I. Carruthers, Wenying Chai, Xiaohu Deng, Curt A. Dvorak, Annette K. Kwok, Jimmy T. Liang, Neelakandha Mani, Dale A. Rudolph, Victoria D. Wong
  • FUSED HETEROCYCLIC COMPOUNDS
    Publication number: 20110040088
    Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Application
    Filed: October 25, 2010
    Publication date: February 17, 2011
    Inventors: Nicholas I. Carruthers, Wenying Chai, Xiaohu Deng, Curt A. Ovorak, Annette K. Kwok, Jimmiy T. Liang, Neelakandha Mani, Dale A. Rudolph, Victoria D. Wong
  • FUSED HETEROCYCLIC COMPOUNDS
    Publication number: 20090270370
    Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Application
    Filed: July 2, 2009
    Publication date: October 29, 2009
    Inventors: Nicholas I. Carruthers, Wenying Chai, Xiaohu Deng, Curt A. Dvorak, Annette K. Kwok, Jimmy T. Liang, Neelakandha Mani, Dale A. Rudolph, Victoria D. Wong
  • OCTAHYDRO-INDOLIZINE AND QUINOLIZINE AND HEXAHYDRO-PYRROLIZINES
    Publication number: 20090263322
    Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
    Type: Application
    Filed: June 30, 2009
    Publication date: October 22, 2009
    Inventors: Richard Apodaca, Nicholas I. Carruthers, John R. Carson, Wenying Chai, Annette K. Kwok, Xiaobing Li, Timothy W. Lovenberg, Dale A. Rudolph, Chandravadan R. Shah
  • Fused heterocyclic compounds
    Patent number: 7402680
    Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: July 22, 2008
    Assignee: Janssen Pharmaceutica, N.V.
    Inventors: Nicholas I. Carruthers, Wenying Chai, Xiaohu Deng, Curt A. Dvorak, Annette K. Kwok, Jimmy T. Liang, Neelakandha Mani, Dale A. Rudolph, Victoria D. Wong
  • NON-PEPTIDIC NPY Y2 RECEPTOR INHIBITORS
    Publication number: 20080132540
    Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
    Type: Application
    Filed: November 19, 2007
    Publication date: June 5, 2008
    Inventors: Nicholas I. Carruthers, Wenying Chai, Scott L. Dax, Jill A. Jablonowski, Xiaobing Li, Timothy W. Lovenberg, William V. Murray, Dale A. Rudolph, Mark Seierstad, Mark A. Youngman
  • FUSED HETEROCYCLIC COMPOUNDS
    Publication number: 20080103132
    Abstract: Certain fused pyrrole- and pyrazole-containing heterocyclic compounds are serotonin modulators useful in the treatment of serotonin-mediated diseases.
    Type: Application
    Filed: October 25, 2007
    Publication date: May 1, 2008
    Inventors: Nicholas Carruthers, Wenying Chai, Xiaohu Deng, Curt Dvorak, Annette Kwok, Jimmy Liang, Neelakandha Mani, Dale Rudolph, Victoria Wong
  • Non-peptidic NPY Y2 receptor inhibitors
    Patent number: 7317025
    Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
    Type: Grant
    Filed: September 24, 2004
    Date of Patent: January 8, 2008
    Assignee: Johnson & Johnson Pharmaceutical Research & Development, LLC
    Inventors: Nicholas I. Carruthers, Wenying Chai, Scott L. Dax, Jill A. Jablonowski, Xiaobing Li, Timothy W. Lovenberg, William V. Murray, Dale A. Rudolph, Mark Seierstad, Mark A. Youngman
  • SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
    Publication number: 20070100141
    Abstract: The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
    Type: Application
    Filed: October 27, 2006
    Publication date: May 3, 2007
    Inventors: Pascal Bonaventure, Nicholas Carruthers, Wenying Chai, Curt Dvorak, Jill Jablonowski, Dale Rudolph, Mark Seierstad, Chandravadan Shah, Devin Swanson, Victoria Wong
  • Octahydro-indolizine and quinolizine and hexahydro-pyrrolizine
    Publication number: 20050288323
    Abstract: The invention features substituted fused bicyclic compounds, pharmaceutical compositions containing them, and methods of using them to treat or prevent histamine-mediated diseases and conditions.
    Type: Application
    Filed: August 17, 2005
    Publication date: December 29, 2005
    Inventors: Richard Apodaca, Nicholas Carruthers, John Carson, Wenying Chai, Annette Kwok, Xiaobing Li, Timothy Lovenberg, Dale Rudolph, Chandravadan Shah