Abstract: The invention discloses small molecular compounds targeting SRSF6 protein, its preparation method and applications. The compound is shown in formula (I). This molecule can selectively inhibit abnormal cells with high expression of SRSF6, thereby reducing the occurrence of abnormal alternative splicing events and inhibiting the occurrence and development of tumors, especially colorectal tumors. It can be used as a candidate new drug for anti-colorectal cancer.

Abstract: Under the action of the movement of the formation crude oil and the production pressure difference, the upper part of the water layer of the oil and gas reservoir is continuously heated within a certain pressure range. The water continues to boil, and the bottom water vapor is used to inhibit and delay the intrusion of bottom water into the oil layer, and the combined driving force of bottom water vapor flooding, bottom hot water flooding formed by the uplift of the oil-water interface and reservoir thermal expansion elastic pressure flooding is used to recover oil and gas.

Abstract: A method for centralized thermal recovery, comprising: first, providing a horizontal well in the upper part of the water layer in which a heating system is configured; then centralized preheating the oil reservoir via electrically heating the water layer, then starting centralized producing the oil after the top of the oil layer reaches an expected temperature. An electric heating system for horizontal well to heat the water, comprising, an inner liner with the upper half slotted, a heat insulation board, a sealing board, a vacuum chamber, an electric heater, a ferrite permanent magnet rod.

Abstract: In one aspect, the invention relates to substituted 6-amino-5,8-dioxo-5,8-dihydronaphthalene-1-sulfonamide analogs and derivatives thereof, substituted 4-amino-5H-naphtho[1,8-cd]isothiazol-5-one 1,1-dioxide analogs and derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: In one aspect, the invention relates to substituted 6-amino-5,8-dioxo-5,8-dihydronaphthalene-1-sulfonamide analogs and derivatives thereof, substituted 4-amino-5H-naphtho[1,8-cd]isothiazol-5-one 1,1-dioxide analogs and derivatives thereof, and related compounds, which are useful as inhibitors of STAT protein activity; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of treating disorders of uncontrolled cellular proliferation associated with a STAT protein activity dysfunction using the compounds and compositions. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.