Abstract: Disclosed are compounds of Formula I, methods of using the compounds for inhibiting KRAS activity and pharmaceutical compositions comprising such compounds. The compounds are useful in treating, preventing or ameliorating diseases or disorders associated with KRAS activity such as cancer.

Abstract: Disclosed are a method and device for controlling the state switching of a fluid torque converter, a vehicle and a storage medium, the method including: obtaining a target instruction when the torque converter of the vehicle is in a locked state, the target instruction triggering a change in the torque transmission direction of a transmission system of the vehicle; obtaining a state parameter, and determining whether the current vehicle is in a target operating condition according to the state parameter; and if the current vehicle is in the target operating condition, switching the fluid torque converter to an open state, and switching the torque converter back to the locked state after maintaining the open state for a preset period of time.

Abstract: Disclosed are a method and device for controlling the state switching of a fluid torque converter, a vehicle and a storage medium, the method including: obtaining a target instruction when the torque converter of the vehicle is in a locked state, the target instruction triggering a change in the torque transmission direction of a transmission system of the vehicle; obtaining a state parameter, and determining whether the current vehicle is in a target operating condition according to the state parameter; and if the current vehicle is in the target operating condition, switching the fluid torque converter to an open state, and switching the torque converter back to the locked state after maintaining the open state for a preset period of time.

Abstract: Disclosed is a hand-held optical apparatus and method for using the apparatus to activate and detect optical emissive materials as part of a safety interlock system. Typically, the hand-held optical apparatus will include one or more light sources capable of emitting at least one wavelength of light towards an optical emissive material, a light detector capable of detecting a response from the optical emissive material, and control circuitry configured to cause at least one of the one or more light sources to emit the at least one wavelength at a power density less than a predetermined threshold, receive a signal from the light detector representing a detected response, and repeat until the microprocessor determines the detected response matches an expected response.