Abstract: The present invention relates to a benzo seven-membered ring bifunctional compound and an application thereof, and in particular to a compound represented by formula (IV) and a pharmaceutically acceptable salt thereof. The compound can be used for preparing a drug for treating diseases related to an estrogen receptor protein degradation targeting chimera.

Abstract: A live flaw detection system for a multi-bundled conductor splicing sleeve and an application method thereof are disclosed. The system includes an upper apparatus and a lower apparatus, where the upper apparatus includes an unmanned aerial vehicle and an industrial X-ray machine, and a laser sensor, and the lower apparatus includes a press plate frame apparatus, vertical screw slide table modules, a horizontal screw slide table module, a projection imager, and a linear retractable apparatus. The unmanned aerial vehicle functions as a power apparatus that controls the system to be online or offline, the industrial X-ray machine is configured to perform ray flaw detection on each splicing sleeve, the laser sensor is configured to guide the unmanned aerial vehicle to land the lower apparatus on splicing sleeves accurately, and the press plate frame apparatus is configured to fixedly clamp the splicing sleeves.

Abstract: A rotating shaft apparatus is provided, where the rotating shaft apparatus includes an adapter member, a spindle, and a crank-slider mechanism. The adapter member is fixedly connected to a load. The spindle is fixedly connected to the adapter member. The crank-slider mechanism acts on the spindle to provide a torque. The torque partially or completely counteracts a gravitational torque of the load. A compression spring is disposed in the crank-slider mechanism. A spring force of the compression spring acts on the spindle, so that the spring force changes with rotation of the spindle.

Abstract: Disclosed are a [1,2,4]triazolo[1,5-a]pyridine compound as JAK inhibitor and an application thereof in preparing a drug for treating a disease related to JAK1 or/and TYK2. Specifically, the present invention relates to a compound represented by formula (I), or an isomer or pharmaceutically acceptable salt thereof.

Abstract: A control device for reducing and homogenizing welding residual stress by acoustic waves, comprising: a fixing tool having two rows of through holes; a plurality of ultrasonic transducers each having a body and a conical horn transmitting portion at a lower end of the body, wherein lower ends of the horn transmitting portions are fixedly connected with flanges, the horn transmitting portions of the ultrasonic transducers extend into respective through holes of the fixing tool to be in contact with welded parts below the fixing tool, the flanges are fixed to the fixing tool by bolts, and the two rows of through holes are arranged both sides of a welding seam of the welded parts; and a driving device for driving the ultrasonic transducers to operate. A corresponding control method is also provided. The control device can be used to control residual stress at the welding seam of steels.

Abstract: Disclosed herein are methods and systems of utilizing sequencing reads for detecting and quantifying the presence of a tissue type or a disease type in cell-free DNA prepared from blood samples.

Abstract: Disclosed herein are methods and systems of utilizing sequencing reads for detecting and quantifying the presence of a tissue type or a disease type in cell-free DNA prepared from blood samples.

Abstract: A high temperature carbon monoxide sensor for in-situ combustion monitoring is provided having a yttrium-stabilized zirconia interface based emf-measuring electrochemical sensor and a nickel oxide (NiO) first sensing electrode for targeting carbon monoxide gas at a temperature range from between about 1000 degrees Centigrade to about 1200 degrees Centigrade. A method of measuring carbon monoxide using this sensor is provided.

Abstract: The present disclosure provides methods and systems for detecting or inferring levels of Copy Number Variants (CNVs) in cell-free nucleic acid samples to detect or assess cancer and prenatal diseases. Cell-free nucleic acid methylation sequencing data may be utilized to distinguish tumor-derived or fetal-derived sequencing reads from normal cfDNA sequencing reads. Each cell-free nucleic acid sequencing read (e.g., containing tumor or fetal methylation markers) may be classified as corresponding to a tumor/fetal-derived or a normal-plasma cell-free nucleic acid, based on the methylation cfDNA sequencing data (e.g., obtained using Bisulfite sequencing or bisulfite-free sequencing methods) and tumor/fetal methylation markers. Next, a profile of the tumor/fetal-derived sequencing read counts may be constructed and then normalized. The CNV status (e.g., gain or loss) of each genomic region may be inferred, and a diagnosis or prognosis can be made based on a subjects inferred CNV profile.

Abstract: The present invention discloses a method for efficiently dispersing carbon nanotubes. The method comprises mixing, in parts by mass, 1-30 parts of carbon nanotubes, 0.2-10 parts of functionalized carbon nanotubes and 400-1200 parts of a solvent, adjusting the pH of the resulting mixture to 5-9, and then ultrasonically dispersing the mixture to obtain a stably dispersed carbon nanotube dispersion; the functionalized carbon nanotube is one or more of a carboxylated carbon nanotube, a hydroxylated carbon nanotube, an aminated carbon nanotube, an acyl-chlorinated carbon nanotube, and a sulfonated carbon nanotube.

Abstract: The present disclosure provides a probabilistic model for accurate and sensitive somatic single nucleotide variant (SNV) detection in cell-free nucleic acid samples comprising a set of sequence data. A joint genotype may be determined for each locus in the set of sequence data, and germline mutations may be intrinsically removed. A set of filtrations can be applied to eliminate low quality somatic variant calls. Further, a global tumor cell-free deoxyribonucleic acid (cfDNA) fraction and overlapping read mates can be considered, thereby enabling accurate SNV detection and variant allele frequency estimation from samples with low tumor cfDNA fraction. A sensitive early detection of minimal residual disease (MRD) is designed by using the probabilistic model and the machine learning model for distinguishing true variants from sequencing errors.

Abstract: Disclosed herein are methods and systems of utilizing sequencing reads for detecting and quantifying the presence of a tissue type or a disease type in cell-free DNA prepared from blood samples.

Abstract: Steam-hydrocarbon reforming reactor with a reformer tube containing ceramic-supported catalyst pellets and metal foam particles. The ceramic-supported catalyst pellets have a porous support comprising one or more of alumina, calcium aluminate, and magnesium aluminate. The metal foam particles comprise Fe and/or Ni. The ceramic-supported catalyst pellets and metal foam particles may be layered or interspersed.

Abstract: Steam-hydrocarbon reforming reactor with a reformer tube containing ceramic-supported catalyst pellets and metal foam particles. The ceramic-supported catalyst pellets have a porous support comprising one or more of alumina, calcium aluminate, and magnesium aluminate. The metal foam particles comprise Fe and/or Ni. The ceramic-supported catalyst pellets and metal foam particles may be layered or interspersed.

Abstract: A focusing method and a focusing system based on a distance sensor of mobile terminal is provided. The method may include: acquiring an initial distance between a camera and an object to be shot by using the distance sensor; judging whether the distance between the camera and the object changed; in response to judging that the distance changed, acquiring a micro-adjustment range of a motor according to the distance; controlling the motor to move based on the micro-adjustment ranges; collecting images from the camera in a real-time manner; acquiring focus values of the collected images; and moving the motor to a position corresponding to a largest focus value of the focus values to focus the camera.

Abstract: A method of identifying voltage instability in a power system via identification of a weakest line and bus that contribute to the collapse of the system is provided. The method includes periodically calculating an extended line stability index for the transmission lines monitored in the power system; and using the extended line stability index to determine the distance of an operation state in the power system from a collapse point of the system caused by voltage instability.

Abstract: A system and method for estimating parameters of transmission lines employing phasor measurement units is provided, wherein measurements are provided from the phasor measurement units relating to a transmission line. These measurements are filtered to remove invalid measurements. Using the remaining valid measurements, resistance, reactance and grounding admittance are calculated and estimated and checked for errors.

Abstract: A system and method for estimating parameters of transmission lines employing phasor measurement units is provided, wherein measurements are provided from the phasor measurement units relating to a transmission line. These measurements are filtered to remove invalid measurements. Using the remaining valid measurements, resistance, reactance and grounding admittance are calculated and estimated and checked for errors.

Abstract: A method of identifying voltage instability in a power system via identification of a weakest line and bus that contribute to the collapse of the system is provided. The method includes periodically calculating an extended line stability index for the transmission lines monitored in the power system; and using the extended line stability index to determine the distance of an operation state in the power system from a collapse point of the system caused by voltage instability.