Patents by Inventor Wenzhao Li

Wenzhao Li has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11453862
    Abstract: Cord blood or peripheral blood NK cells are prepared from whole blood mononuclear cells without the need to isolate CD34+ hematopoietic stem cells or NK cells, and without the need for a feeder layer. Advantageously, the methods presented herein use an enrichment process that uses antiCD16 agonist antibodies, antiCD3 antibodies, and N-803. Moreover, contemplated processes are suitable for adaptation into a fully automated production process (GMP in a box).
    Type: Grant
    Filed: July 8, 2019
    Date of Patent: September 27, 2022
    Assignee: ImmunityBio, Inc.
    Inventors: Rohit Duggal, Ranjeet Sinha, Wenzhao Li, Jason Isaacson, Karl Marquez, Patrick Soon-Shiong
  • Publication number: 20210361711
    Abstract: Cytokine induced memory like (CIML) NK cells with enhanced cytotoxicity are presented. Most typically, the CIML NK cells are derived from a mononuclear cell fraction of peripheral blood or cord blood. In further contemplated aspects, the CIML NK cells are expanded and induced in a contained and automated production environment that substantially reduces operational complexity and production cost.
    Type: Application
    Filed: July 14, 2021
    Publication date: November 25, 2021
    Inventors: Rohit Duggal, Ranjeet Sinha, Wenzhao Li, Jason Isaacson, Patrick Soon-Shiong
  • Publication number: 20210153537
    Abstract: The disclosure relates to a compound beverage containing corn peptides and Pueraria root extract which can alleviate hangover with high contents of nutrients and desired palatability and stability. The compound beverage includes components in parts by weight as follows: 0.35-0.75 parts of corn peptides, 0.1-0.5 parts of Pueraria root extract, 6-10 parts of sweetener, 0.2-1.0 parts of ?-cyclodextrin, 0.1-0.3 parts of sour agent, 0.1-0.5 parts of fruit juice concentrate, 0.05-0.13 parts of stabilizer, and treated water as balance. The compound beverage containing corn peptides of the disclosure uses corn peptides as a main component. The corn peptides have high nutrition value and can supplement a variety of amino acids necessary for the human body. At the same time, Pueraria root extract is added which can lower blood pressure, dilate coronary arteries and regulate alcohol metabolism.
    Type: Application
    Filed: November 18, 2020
    Publication date: May 27, 2021
    Inventors: Wenzhao LI, Miaomiao TIAN, Jialin TANG
  • Publication number: 20210009954
    Abstract: Cord blood or peripheral blood NK cells are prepared from whole blood mononuclear cells without the need to isolate CD34+ hematopoietic stem cells or NK cells, and without the need for a feeder layer. Advantageously, the methods presented herein use an enrichment process that uses antiCD16 agonist antibodies, antiCD3 antibodies, and N-803. Moreover, contemplated processes are suitable for adaptation into a fully automated production process (GMP in a box).
    Type: Application
    Filed: February 20, 2020
    Publication date: January 14, 2021
    Inventors: Rohit Duggal, Ranjeet Sinha, Wenzhao Li, Jason Isaacson, Karl Marquez, Patrick Soon-Shiong
  • Publication number: 20210009953
    Abstract: Cord blood or peripheral blood NK cells are prepared from whole blood mononuclear cells without the need to isolate CD34+ hematopoietic stem cells or NK cells, and without the need for a feeder layer. Advantageously, the methods presented herein use an enrichment process that uses antiCD16 agonist antibodies, antiCD3 antibodies, and N-803. Moreover, contemplated processes are suitable for adaptation into a fully automated production process (GMP in a box).
    Type: Application
    Filed: July 8, 2019
    Publication date: January 14, 2021
    Inventors: Rohit Duggal, Ranjeet Sinha, Wenzhao Li, Jason Isaacson, Karl Marquez, Patrick Soon-Shiong
  • Publication number: 20210008112
    Abstract: Cytokine induced memory like (CIML) NK cells with enhanced cytotoxicity are presented. Most typically, the CIML NK cells are derived from a mononuclear cell fraction of peripheral blood or cord blood. In further contemplated aspects, the CIML NK cells are expanded and induced in a contained and automated production environment that substantially reduces operational complexity and production cost.
    Type: Application
    Filed: August 5, 2020
    Publication date: January 14, 2021
    Inventors: Rohit Duggal, Ranjeet Sinha, Wenzhao Li, Jason Isaacson, Patrick Soon-Shiong
  • Publication number: 20210008107
    Abstract: Cytokine induced memory like (CIML) NK cells with enhanced cytotoxicity are presented. Most typically, the CIML NK cells are derived from a mononuclear cell fraction of peripheral blood or cord blood. In further contemplated aspects, the CIML NK cells are expanded and induced in a contained and automated production environment that substantially reduces operational complexity and production cost.
    Type: Application
    Filed: July 8, 2019
    Publication date: January 14, 2021
    Inventors: Rohit Duggal, Ranjeet Sinha, Wenzhao Li, Jason Isaacson, Patrick Soon-Shiong
  • Patent number: 10609141
    Abstract: Apparatuses and methods are disclosed for cluster switching. An exemplary method may include synchronizing original data on a first cluster to a second cluster after starting to switch clusters. A priority of the original data on the second cluster is set to a lower priority. The method may also include responding to a write operation request on the second cluster in the period of synchronizing the original data on the first cluster to the second cluster. A priority of new data corresponding to the write operation request is set to a higher priority. A version of data with a higher priority can overwrite another version of data. The method may further include responding to the write operation request on the second cluster after synchronizing the original data on the first cluster to the second cluster.
    Type: Grant
    Filed: January 12, 2018
    Date of Patent: March 31, 2020
    Assignee: ALIBABA GROUP HOLDING LIMITED
    Inventors: Ting Zhang, Zhongyu Zou, Wenzhao Li, Ming Yang, Jinbo Wu
  • Patent number: 10599337
    Abstract: The present application provides methods and devices for writing data and acquiring data in a distributed storage system. According to an exemplary method, in a process of writing data, a data file is not overwritten but is instead updated by making a copy in a newly allocated storage block and an updated description file is persisted by using an atomic operation. This way, in a process of appending data, it can be ensured that a data file is not damaged, and the readability and consistency of data are maintained, facilitating the use by a user. Further, writing data according to some embodiments of the present application supports a write in which a user specifies a write position of to-be-written data, and also supports a write in which the user does not specify a write position of to-be-written data, thereby improving the flexibility of writing data.
    Type: Grant
    Filed: March 8, 2018
    Date of Patent: March 24, 2020
    Assignee: ALIBABA GROUP HOLDING LIMITED
    Inventors: Ming Yang, Wenzhao Li, Zhongyu Zou
  • Publication number: 20180203606
    Abstract: The present application provides methods and devices for writing data and acquiring data in a distributed storage system. According to an exemplary method, in a process of writing data, a data file is not overwritten but is instead updated by making a copy in a newly allocated storage block and an updated description file is persisted by using an atomic operation. This way, in a process of appending data, it can be ensured that a data file is not damaged, and the readability and consistency of data are maintained, facilitating the use by a user. Further, writing data according to some embodiments of the present application supports a write in which a user specifies a write position of to-be-written data, and also supports a write in which the user does not specify a write position of to-be-written data, thereby improving the flexibility of writing data.
    Type: Application
    Filed: March 8, 2018
    Publication date: July 19, 2018
    Inventors: Ming YANG, Wenzhao LI, Zhongyu ZOU
  • Publication number: 20180139280
    Abstract: Apparatuses and methods are disclosed for cluster switching. An exemplary method may include synchronizing original data on a first cluster to a second cluster after starting to switch clusters. A priority of the original data on the second cluster is set to a lower priority. The method may also include responding to a write operation request on the second cluster in the period of synchronizing the original data on the first cluster to the second cluster. A priority of new data corresponding to the write operation request is set to a higher priority. A version of data with a higher priority can overwrite another version of data. The method may further include responding to the write operation request on the second cluster after synchronizing the original data on the first cluster to the second cluster.
    Type: Application
    Filed: January 12, 2018
    Publication date: May 17, 2018
    Inventors: Ting ZHANG, Zhongyu ZOU, Wenzhao LI, Ming YANG, Jinbo WU
  • Patent number: 8052775
    Abstract: Process for preparing a two layer metal palladium or palladium alloy composite membrane consisting of a porous substrate support and a palladium or palladium alloy membrane by rinsing/washing and drying the porous substrate support, treating the porous substrate support with a pore filler in order to decorate the pores of the support and the disfigurements of the substrate surface, sensitizing and activating with a palladium solution the decorated substrate support, and plating the resulting support with a palladium solution to form the two layer composite membrane, drying. The resulting composite membrane is subjected to a post-processing where the pore fillers residing in the pore-channels of the porous substrate are partly removed or reduced in volume through heating.
    Type: Grant
    Filed: January 7, 2005
    Date of Patent: November 8, 2011
    Assignees: BP P.L.C., Dalian Institute of Chemical Physics
    Inventors: Shoufu Hou, Kui Jiang, Wenzhao Li, Hengyong Xu, Lixiang Yuan
  • Publication number: 20090264543
    Abstract: The present invention relates to a novel integrated process for the co-production of methanol and dimethyl ether (DME) from syngas containing nitrogen, which is based on a two-stage reaction. In the first stage, most of the syngas is converted into methanol by using one reactor or two tandem reactors or multistage series reactors. In the second stage, the small amount of remaining syngas is further diluted by N2 and is converted to DME in the following reactor. Thus, the catalyst sintering is avoided due to the alleviated heat transfer limitations. An overall CO single pass conversion as high as ˜90% is obtained, which is maintained during 2000 h's of continuous operation. This invention provides a novel, economic and easy to operate process to convert syngas to methanol/DME in single pass.
    Type: Application
    Filed: August 1, 2005
    Publication date: October 22, 2009
    Applicants: BP, P.L.C., Dalian Institute of Chemical Physics Chinese Academy of Sciences
    Inventors: Hengyong Xu, Qingjie Ge, Chunhua Tang, Shoufu Hou, Wenzhao Li
  • Publication number: 20090130477
    Abstract: The present invention relates to a metal palladium composite membrane or an alloy palladium composite membrane in which essentially the metal palladium membrane or alloy palladium membrane exists substantially on the outer surface of the porous substrate support, with little or no presence in the pore channels of the support, and to process for its preparation. The process comprises the steps of treating the porous substrate with a pore filler before plating it with a palladium solution to form the composite membrane.
    Type: Application
    Filed: January 7, 2005
    Publication date: May 21, 2009
    Applicants: BP P.L.C., DALIAN INSTITUTE OF CHEMICAL PHYSICS
    Inventors: Shoufu Hou, Kui Jiang, Wenzhao Li, Hengyong Xu, Lixiang Yuan