Abstract: In an aspect, a data processing system includes a computer-readable memory comprising computer-executable instructions, and at least one processor configured to execute executable logic including at least one artificial neural network trained to predict one or more responses to a chemical substance by identifying one or more discrete biological tissue components in a biological image. When the at least one processor is executing the computer-executable instructions, the at least one processor is configured to carry out operations including: receiving spatially arranged image data representing a biological image of a patient; generating spatially arranged image tile data representing a plurality of image tiles; processing the spatially arranged image tile data through one or more data structures storing one or more portions of executable logic included in the artificial neural network to predict one or more responses of a patient.