Patents by Inventor Wera Hofmann
Wera Hofmann has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11965207Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: GrantFiled: July 28, 2020Date of Patent: April 23, 2024Assignee: EUROFINS LIFECODEXX GMBHInventors: Sebastian Grömminger, Wera Hofmann, Hamed Said, Matthias Sachse
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Patent number: 11773443Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: GrantFiled: June 11, 2018Date of Patent: October 3, 2023Assignee: EUROFINS LIFECODEXX GMBHInventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Patent number: 11753684Abstract: Methods for detecting a chromosomal aneuploidy in a foetus carried by a pregnant female are provided. Such methods are based on one or more of particular configurations and/or detections and/or analyses of two or more regions of DNA, including those that show differential methylation between DNA that originates from cells of a foetus (and/or the placenta of a foetus) and DNA of maternal origin. Such methods utilise a sample taken from a pregnant female, which sample comprises DNA that originates from cells of a foetus and/or the placenta of a foetus in admixture with differently methylated DNA of maternal origin. Such methods have diagnostic, prognostic and/or predictive utility; in particular for the detection/diagnosis of chromosomal aneuploidy, such as a trisomy, in a foetus, and/or for detecting an increased risk of a pregnant female suffering from or developing a pregnancy-associated medical condition.Type: GrantFiled: November 9, 2016Date of Patent: September 12, 2023Assignee: EUROFINS LIFECODEXX GMBHInventors: Steffi Werler, Wera Hofmann, Matthias Sachse
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Publication number: 20200407793Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: ApplicationFiled: July 28, 2020Publication date: December 31, 2020Inventors: Sebastian Grömminger, Wera Hofmann, Hamed Said, Matthias Sachse
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Patent number: 10801067Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: GrantFiled: May 8, 2015Date of Patent: October 13, 2020Assignee: Eurofins LifeCodexx GmbHInventors: Sebastian Grömminger, Wera Hofmann, Hamed Said, Matthias Sachse
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Publication number: 20190249249Abstract: The present invention relates to methods for detecting a chromosomal aneuploidy in a foetus carried by a pregnant female. Such methods are based on one or more of particular configurations and/or detections and/or analyses of two or more regions of DNA, including those that show differential methylation between DNA that originates from cells of a foetus (and/or the placenta of a foetus) and DNA of maternal origin. Such methods utilise a sample taken from said pregnant female, which sample comprises DNA that originates from cells of a foetus and/or the placenta of a foetus in admixture with differently methylated DNA of maternal origin. Such methods have diagnostic, prognostic and/or predictive utility; in particular for the detection/diagnosis of chromosomal aneuploidy, such as a trisomy, in a foetus, and/or for detecting an increased risk of a pregnant female suffering from or developing a pregnancy-associated medical condition.Type: ApplicationFiled: November 9, 2016Publication date: August 15, 2019Inventors: Steffi Werler, Wera Hofmann, Matthias Sachse
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Publication number: 20180334715Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: ApplicationFiled: June 11, 2018Publication date: November 22, 2018Inventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Patent number: 10017818Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on different methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumor.Type: GrantFiled: May 8, 2015Date of Patent: July 10, 2018Assignee: LifeCodexx AGInventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Publication number: 20170363628Abstract: The invention relates to a prenatal diagnostic method for the determination of a fetal chromosomal aneuploidy in a biological sample obtained from a pregnant woman, which method comprises enrichment and quantification of selected cell-free deoxyribonucleic acid sequences showing consensus nucleosome binding regions.Type: ApplicationFiled: September 6, 2017Publication date: December 21, 2017Applicant: LifeCodexxInventors: Marcus BENZ, Wera HOFMANN, Thomas POHL, Christoph Von KALLE
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Patent number: 9822412Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumor.Type: GrantFiled: May 8, 2015Date of Patent: November 21, 2017Assignee: LifeCodexx AGInventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Patent number: 9822413Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumor.Type: GrantFiled: May 8, 2015Date of Patent: November 21, 2017Assignee: LifeCodexx AGInventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Publication number: 20170314073Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: ApplicationFiled: May 8, 2015Publication date: November 2, 2017Inventors: Sebastian Grömminger, Wera Hofmann, Hamed Said, Matthias Sachse
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Patent number: 9784742Abstract: The invention relates to a prenatal diagnostic method for the determination of a fetal chromosomal aneuploidy in a biological sample obtained from a pregnant woman, which method comprises enrichment and quantification of selected cell-free deoxyribonucleic acid sequences showing consensus nucleosome binding regions.Type: GrantFiled: October 26, 2010Date of Patent: October 10, 2017Assignee: LifeCodexxInventors: Marcus Benz, Wera Hofmann, Thomas Pohl, Christoph Von Kalle
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Publication number: 20150322512Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on different methylation, at certain regions of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: ApplicationFiled: May 8, 2015Publication date: November 12, 2015Inventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Publication number: 20150322513Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA thst originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: ApplicationFiled: May 8, 2015Publication date: November 12, 2015Inventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Publication number: 20150322511Abstract: The present invention relates to methods to detect an amount of DNA that originates from cells of a given type, where the sample comprising such DNA in admixture with DNA that does not originate from such cells. Such methods are based on differential methylation, at certain regions, of the DNA that originates from the given type of cells compared to the admixed DNA. Such methods have particular application in the detection, from a biological fluid from a pregnant female, of cell free DNA that originates from a foetus or the placenta of a foetus, or the detection, from a biological fluid from an individual, of cell free DNA that originates from cells of a tumour.Type: ApplicationFiled: May 8, 2015Publication date: November 12, 2015Inventors: Sebastian Gromminger, Wera Hofmann, Hamed Said
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Publication number: 20130017958Abstract: The invention relates to a prenatal diagnostic method for the determination of a fetal chromosomal aneuploidy in a biological sample obtained from a pregnant woman, which method comprises enrichment and quantification of selected cell-free deoxyribonucleic acid sequences showing consensus nucleosome binding regions.Type: ApplicationFiled: October 26, 2010Publication date: January 17, 2013Inventors: Marcus Benz, Wera Hofmann, Thomas Pohl, Christoph Von Kalle