Patents by Inventor Werner Aretz

Werner Aretz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Calcium salts of lipopeptide antibiotics, method for producing same and their use
    Patent number: 6624143
    Abstract: The invention relates to a calcium salt of the compound of formula (II), where R1 is a straight-chain or branched, saturated or unsaturated aliphatic acyl radical having 8 to 22 carbon atoms, which can optionally be interrupted by or linked to one or more phenyl or cycloalkyl groups and optionally interrupted by oxygen. The invention also relates to a method for producing said calcium salt and to its use as a medicine.
    Type: Grant
    Filed: August 25, 2000
    Date of Patent: September 23, 2003
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Laszló Vértesy, Werner Aretz, Heinrich Decker, Eberhard Ehlers, Michael Kurz, Frank Rainer Schmidt
  • Process for using the yeast ADH II promoter system for the production of heterologous proteins in high yields
    Patent number: 5866371
    Abstract: The invention relates to a novel process for using the yeast ADH II promoter system for the production of heterologous proteins in high yields, for example for preparing hirudins, miniproinsulins, leptins or derivatives thereof.
    Type: Grant
    Filed: November 27, 1996
    Date of Patent: February 2, 1999
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Badziong, Paul Habermann, Joerg Moeller, Werner Aretz
  • Process for the preparation of glutarylacylase in large quantities
    Patent number: 5830743
    Abstract: The gene encoding glutarylacylase (GA) contained in the plasmid pCM 145 (DSM 6409) permits the expression of GA in E. coli in high yields.
    Type: Grant
    Filed: September 28, 1994
    Date of Patent: November 3, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Klaus-Peter Koller, Gunther Johannes Riess, Werner Aretz
  • Induction-free process for the recombinant preparation of glutarylamidase
    Patent number: 5766881
    Abstract: Improved, induction-free process for the recombinant preparation of glutarylamidase. The invention relates to a recombinant process for preparing glutarylamidase (GA), wherein the GA gene is expressed constitutively from an expression vector. In certain embodiments, the promoter for constitutively expressing the GA gene is a trc promoter or a trc-equivalent promoter which does not have any repressor or has a non-functional repressor.
    Type: Grant
    Filed: October 17, 1995
    Date of Patent: June 16, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Ulrich Holst, Klaus Peter Koller
  • Oxygen-dependent fermentation of microorganisms
    Patent number: 5714348
    Abstract: The present invention relates to a growth-coupled fed-batch fermentation of oxygen-dependent microorganisms. It has been found that oxygen-dependent microorganisms can be advantageously fermented if the carbon supply is carried out as a function of the oxygen uptake rate.
    Type: Grant
    Filed: August 20, 1996
    Date of Patent: February 3, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Philipp Willems
  • 7-methoxymethly-3-methyl-1-(5-oxohexyl)xanthine
    Patent number: 5710272
    Abstract: A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be convened into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereoselectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: January 20, 1998
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Harald Furrer, Ulrich Gebert, Heinz-Joachim Hinze
  • Process for the preparation of L-phosphinothricin using transaminases of different specificities in a linked process
    Patent number: 5587319
    Abstract: L-2-Amino-4-methylphosphinobutyric acid can be prepared by a racemate resolution in the presence of D-aminoacid and L-aminoacid transaminases by reaction with .alpha.-keto acids and amino-group donors. In particular, transaminases from Bacillus licheniformis and from Escherichia coli are used.
    Type: Grant
    Filed: July 8, 1994
    Date of Patent: December 24, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Johann Then, Werner Aretz, Klaus Sauber
  • 7-amino-3-methoxymethyl-3-cephem-4-carboxylic ester hydrolase, process for its preparation, and its use
    Patent number: 5527697
    Abstract: An esterase with a molecular weight of 55,200 .+-.300 Da is suitable for the chemoselective conversion of a compound of the formula II into a compound of the formula I.
    Type: Grant
    Filed: July 12, 1994
    Date of Patent: June 18, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Klaus Sauber
  • Chelating agents, their preparation from the antibiotics salmycin A,B,C, or D, and their use
    Patent number: 5519123
    Abstract: The novel substances nordanoxamine and desferrinordanoxamine, and desferrisalmycin A, B, C and D, as well as the known substances danoxamine and desferridanoxamine, are prepared from the antibiotics salmycin A, B, C and D, which are obtained by fermentation. These substances are used as chelating agents and pharmaceuticals.
    Type: Grant
    Filed: August 5, 1994
    Date of Patent: May 21, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Werner Aretz, Hans-Wolfram Fehlhaber
  • Bacillus strain for breaking down moenomycins
    Patent number: 5506140
    Abstract: A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.
    Type: Grant
    Filed: March 14, 1995
    Date of Patent: April 9, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Dirk Bottger, Gerhard Seibert, Alois Tumulka, Peter Welzel, Kurt Hobert
  • Salmycins, a process for their preparation and their use as a pharmaceutical
    Patent number: 5475094
    Abstract: Salmycins, a process for their preparation and their use as a pharmaceutical Compounds of formula I, ##STR1## wherein R denotes .dbd.NOH (a), .dbd.O (b); --OH and --H (c), --NH.sub.2 and --H (d) or .dbd.N--O--R'(e);R' denotes phenyl or a branched or unbranched alkyl with 1 to 10 carbon atoms,R" denotes H, alkyl, hydroxy-alkyl and amino-alkyl, as well as the chemical equivalents and physiologically acceptable salts thereof. The salmycins and their derivatives are used as a pharmaceutical.
    Type: Grant
    Filed: August 11, 1994
    Date of Patent: December 12, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Laszlo Vertesy, Werner Aretz, Hans-Wolfram Fehlhaber, Bimal N. Ganguli
  • Rhodotorula rubra useful in a process for the preparation of (.omega.-1)-hydroxyalkylxanthines
    Patent number: 5472873
    Abstract: A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be converted into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereo-selectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.
    Type: Grant
    Filed: February 10, 1994
    Date of Patent: December 5, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Harald Furrer, Ulrich Gebert, Heinz-Joachim Hinze
  • Process for the preparation of MA
    Patent number: 5316929
    Abstract: The invention relates to a process for the preparation of MA, which ensures MA production by enzymatic catalysis in glycine/NaOH buffer, and by the use of a phosphate-containing culture medium for Bacillus sp. DSM 4675 and by extraction of the biomass with acetone.
    Type: Grant
    Filed: August 11, 1993
    Date of Patent: May 31, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Eberhard Ehlers, Udo Hedtmann
  • Microorganism for breaking down moenomycins, a process for the breakdown, and the use of the breakdown products
    Patent number: 5315038
    Abstract: A new microorganism for breaking down moenomycins, a process for the breakdown, and the use of the breakdown products are disclosed. A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.
    Type: Grant
    Filed: April 20, 1993
    Date of Patent: May 24, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Dirk Bottger, Gerhard Seibert, Alois Tumulka, Peter Welzel, Kurt Hobert
  • Process for the enantioselective preparation of (.beta.-1)-hydroxyalkylxanthines by reduction using Rhodotorula rubra
    Patent number: 5310666
    Abstract: A Rhodotorula rubra strain has been found which reduces pentoxifylline to 100% to give the S-alcohol. Moreover, other oxoalkylxanthine derivatives can also be converted into the corresponding S-alcohol. The microbiologically obtained S-(+)-enantiomers can then be converted stereoselectively into the respective R-(-)-enantiomers. The corresponding S-alcohols and the R-alcohols obtained by enantioselective inversion of configuration cause an increase in cerebral blood flow.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: May 10, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Harald Furrer, Ulrich Gebert, Heinz-Joachim Hinze
  • Enzymes for breaking down moenomycins
    Patent number: 5260206
    Abstract: A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylas inhibitors.
    Type: Grant
    Filed: September 3, 1992
    Date of Patent: November 9, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Dirk Bottger, Gerhard Seibert, Alois Tumulka, Peter Welzel, Kurt Hobert
  • 2-alkenyloxy-3-(phosphono)oxypropanoic acids derived from the cleavage of phosphoglycolipid antibiotics
    Patent number: 5206405
    Abstract: A new Bacillus species and the appropriate enzymes obtained therefrom can be used to break down phosphoglycolipid antibiotics. The breakdown products of moenomycins display antibiotic activity or can be used as building blocks for the synthetic preparation of transglycosylase inhibitors.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: April 27, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Dirk Bottger, Gerhard Seibert, Alois Tumulka, Peter Welzel, Kurt Hobert
  • .gamma.-glutamyltranspeptidase, its preparation and its use
    Patent number: 4990444
    Abstract: It is possible with the aid of a .gamma.-glutamyltranspeptidase, which can be prepared by fermentation, to hydrolyze adipinyl- or glutaryl-monoamino compounds, in particular .alpha.-keto-adipinyl- or glutaryl-7-aminocephalosporanic acid.
    Type: Grant
    Filed: January 15, 1988
    Date of Patent: February 5, 1991
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Klaus Sauber
  • L-aminoacid oxidase from yeasts of the genus cryptococcus, their preparation and use
    Patent number: 4783404
    Abstract: Yeasts of the genus cryptococcus, preferably of the species C. Laurentii, form, in the presence of aminoacids, an L-aminoacid oxidase which stereospecifically converts L-aminoacids and their derivatives into the corresponding .alpha.-ketoacids. The immobilized cells are advantageously used for this conversion, which can also be used to resolve racemates.
    Type: Grant
    Filed: September 14, 1984
    Date of Patent: November 8, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Klaus Sauber
  • Novel d-aminoacid transaminase and its use
    Patent number: 4745061
    Abstract: A D-aminoacid transaminase which converts CPC with .DELTA.-keto acids into .DELTA.-ketoadipinyl-7-ACA can be isolated from Bacillus Licheniformis ATCC 9945. This transamination can be applied to other D-amino acids and can also be used for the preparation of D-amino acids from .DELTA.-keto acids. The enzyme is also suitable for resolving racemates of D,L-amino acids and for detection of .DELTA.-keto acids alongside L-amino acids.
    Type: Grant
    Filed: December 20, 1985
    Date of Patent: May 17, 1988
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Werner Aretz, Klaus Sauber