Patent number: 6423851
Abstract: The present invention provides a process for preparing of d,l-&agr;-tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol. This process includes carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine [HN(SO2CF3)2] or a metal salt thereof of the formula Met (N(SO2CF3)2)n (I) as the catalyst and supercritical carbon dioxide or nitrous oxide as the solvent, wherein Met is a metal atom such as for example boron, magnesium, aluminum, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, neodymium, praseodymium, europium, dysprosium, ytterbium, hafnium, platinum and gold, and n is the corresponding valency (1, 2, 3, or 4) of the metal atom Met. A cosolvent may also be used, which is a lower aliphatic alkanol, ketone or hydrocarbon. The product of the process is the most active member of the vitamin E group.
Type:
Grant
Filed:
August 17, 2001
Date of Patent:
July 23, 2002
Assignee:
Roche Vitamins Inc.
Inventors:
Werner Bonrath, Shaoning Wang
Publication number: 20020010347
Abstract: The present invention provides a process for preparing of d,l-&agr;-tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol. This process includes carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine [HN(SO2CF3)2] or a metal salt thereof of the formula Met (N(SO2CF3)2)n (I) as the catalyst and supercritical carbon dioxide or nitrous oxide as the solvent, wherein Met is a metal atom such as for example boron, magnesium, aluminum, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, neodymium, praseodymium, europium, dysprosium, ytterbium, hafnium, platinum and gold, and n is the corresponding valency (1, 2, 3, or 4) of the metal atom Met. A cosolvent may also be used, which is a lower aliphatic alkanol, ketone or hydrocarbon. The product of the process is the most active member of the vitamin E group.
Type:
Application
Filed:
August 17, 2001
Publication date:
January 24, 2002
Applicant:
ROCHE VITAMINS INC.
Inventors:
Werner Bonrath, Shaoning Wang
Patent number: 5908939
Abstract: A process for the manufacture of d,1-.alpha.-tocopherol by the catalyzed condensation of trimethylhydroquinone with isophytol comprises carrying out the condensation in the presence of bis-(trifluoromethylsulphonyl)amine ?HN(SO.sub.2 CF.sub.3).sub.2 ! or a metal salt thereof of the formula Met ?N(SO.sub.2 CF.sub.3).sub.2 !.sub.n (I), wherein Met signifies a metal atom selected from the group of lithium, boron, magnesium, aluminium, silicon, scandium, titanium, vanadium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, rhodium, palladium, silver, tin, lanthanum, cerium, neodymium, praseodymium, europium, dysprosium, ytterbium, hafnium, platinum and gold and n signifies the corresponding valency (1, 2, 3, or 4) of the metal atom Met, as the catalyst or of a combination of a metal salt of formula I and a strong Bronsted acid as the catalyst system in an organic solvent. The product of the process is the most active member of the vitamin E group.
Type:
Grant
Filed:
October 16, 1997
Date of Patent:
June 1, 1999
Assignee:
Roche Vitamins Inc.
Inventors:
Marcel Baak, Werner Bonrath, Horst Pauling