Patents by Inventor Werner Brox
Werner Brox has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9907756Abstract: The present invention relates to a suspension formulation containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate, to a capsule pharmaceutical dosage form containing said suspension formulation, to a process for preparing said suspension formulation, to a process for preparing said capsule comprising said suspension formulation and to the packaging material for the finished capsule.Type: GrantFiled: July 7, 2016Date of Patent: March 6, 2018Assignee: Boehringer Ingelheim International GmbHInventors: Roman Messerschmid, Rudolf Binder, Thomas Bock, Werner Brox
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Publication number: 20160324791Abstract: The present invention relates to a suspension formulation containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl -methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate, to a capsule pharmaceutical dosage form containing said suspension formulation, to a process for preparing said suspension formulation, to a process for preparing said capsule comprising said suspension formulation and to the packaging material for the finished capsule.Type: ApplicationFiled: July 7, 2016Publication date: November 10, 2016Inventors: Roman MESSERSCHMID, Rudolf BINDER, Thomas BOCK, Werner BROX
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Publication number: 20160022672Abstract: The present invention relates to a suspension formulation containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate, to a capsule pharmaceutical dosage form containing said suspension formulation, to a process for preparing said suspension formulation, to a process for preparing said to capsule comprising said suspension formulation and to the packaging material for the finished capsule.Type: ApplicationFiled: October 7, 2015Publication date: January 28, 2016Inventors: Roman MESSERSCHMID, Rudolf BINDER, Thomas BOCK, Werner BROX
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Publication number: 20140004187Abstract: The present invention relates to a suspension formulation containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate, to a capsule pharmaceutical dosage form containing said suspension formulation, to a process for preparing said suspension formulation, to a process for preparing said capsule comprising said suspension formulation and to the packaging material for the finished capsule.Type: ApplicationFiled: August 30, 2013Publication date: January 2, 2014Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Roman MESSERSCHMID, Rudolf BINDER, Thomas BOCK, Werner BROX
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Publication number: 20110301177Abstract: The present invention relates to a suspension formulation containing the active substance 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)-anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone-monoethanesulphonate, to a capsule pharmaceutical dosage form containing said suspension formulation, to a process for preparing said suspension formulation, to a process for preparing said capsule comprising said suspension formulation and to the packaging material for the finished capsule.Type: ApplicationFiled: June 4, 2009Publication date: December 8, 2011Applicant: BOEHRINGER INGELHEIM INTERNATIONAL GMBHInventors: Roman Messerschmid, Rudolf Binder, Thomas Bock, Werner Brox
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Patent number: 7078054Abstract: Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule filling and in the capsule shell. The manufacture of said capsules is improved, if in the process for making the soft gelatin capsules the gelatin bands are cooled with a liquid, and preferably with water.Type: GrantFiled: May 13, 2003Date of Patent: July 18, 2006Assignee: Novartis AGInventors: Werner Brox, Armin Meinzer, Horst Zande
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Publication number: 20030206930Abstract: Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule filling and in the capsule shell. The manufacture of said capsules is improved, if in the process for making the soft gelatin capsules the gelatin bands are cooled with a liquid, and preferably with water.Type: ApplicationFiled: May 13, 2003Publication date: November 6, 2003Inventors: Werner Brox, Armin Meinzer, Horst Zande
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Patent number: 6589536Abstract: Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule filling and in the capsule shell. The manufacture of said capsules is improved, if in the process for making the soft gelatin capsules the gelatin bands are cooled with a liquid, and preferably with water.Type: GrantFiled: February 7, 2000Date of Patent: July 8, 2003Assignee: Novartis AGInventors: Werner Brox, Armin Meinzer, Horst Zande
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Patent number: 6555132Abstract: Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule filling and in the capsule shell. The manufacture of said capsules is improved, if in the process for making the soft gelatin capsules the gelatin bands are cooled with a liquid, and preferably with water.Type: GrantFiled: October 17, 2000Date of Patent: April 29, 2003Assignee: Novartis AGInventors: Werner Brox, Armin Meinzer, Horst Zande
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Patent number: 5985321Abstract: Soft gelatin capsules having a capsule shell comprising gelatin, plasticizers and, if desired or required, further auxiliary agents, and a capsule filling containing a solvent including a migrateable solvent such as 1,2-propyleneglycol as a solvent in the capsule filling and in the capsule shell. The manufacture of said capsules is improved, if in the process for making the soft gelatin capsules the gelatin bands are cooled with a liquid, and preferably with water.Type: GrantFiled: April 29, 1997Date of Patent: November 16, 1999Assignees: Novartis AG, R.P. Scherer GmbHInventors: Werner Brox, Armin Meinzer, Horst Zande
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Patent number: 5529767Abstract: This invention is comprised of printed shaped bodies and sheets comprising gelatin or having at least an outer surface comprised of at least 5% gelatin or chemically modified gelatin, the shaped bodies and sheets being printed with ink by an ink jet. In particular, the ink applied to the shaped bodies and sheets by the ink jet contains an aluminum and/or calcium compound in addition to dyes and/or pigments, or an aluminum and/or calcium dye compound, and optionally non-volatile proportions of solubilizers and/or dispersants. Further, where the ink contains an aluminum compound, the ink is preferably adjusted to alkaline condition. The invention allows shaped bodies or sheets of gelatin to be printed with ink that is unlikely to be transferred in the form of "ghost images" to adjacent shaped bodies or sheets.Type: GrantFiled: June 5, 1995Date of Patent: June 25, 1996Assignee: R. P. Scherer CorporationInventors: Werner Brox, Peter Block, Reiner Schafer
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Patent number: 4891229Abstract: Soft gelatin capsules with a gelatin shell, at least one plasticizer and a capsule filling that contains at least one pharmacologically-active substance and a solvent containing at least 50% by weight of a mixture of polyethylene glycol ethers of tetrahydrofurfuryl alcohol having the formula I ##STR1## where n=1 to 6. The capsules must be dried for 5 to 10 days in manufacture.Type: GrantFiled: October 14, 1988Date of Patent: January 2, 1990Inventors: Werner Brox, Wilfried Gabler
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Patent number: 4888239Abstract: Gelatin capsules of the type having an outer shell comprising gelatin and, optionally, a plasticizer, and a capsule filling, the filling containing at least one active substance and/or a dietetic agent or foodstuff as well as a solvent mixture, the solvent mixture containing about 5-50% by weight, preferably 10-30% by weight of ethanol and about 20-95% by weight, preferably 40-90% by weight of one or more of partial glycerides of fatty acids havig from 6 to 18 carbon atoms. The capsules are prepared by dissolving the active ingredients in the solvent mixture and filling the resulting mixture into the gelatin capsules.Type: GrantFiled: August 25, 1987Date of Patent: December 19, 1989Assignee: R. P. Scherer CorporationInventor: Werner Brox
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Patent number: 4829057Abstract: Soft elastic gelatin capsules containing primarily the crystalline form A of oxytetracycline hydrochloride exhibit increased storage ability.Type: GrantFiled: May 13, 1988Date of Patent: May 9, 1989Assignee: R. P. Scherer CorporationInventors: Werner Brox, Artur Burger
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Patent number: 4780316Abstract: A pharmaceutical dosage unit form comprises one or more pharmaceutically active materials dissolved or suspended in a liquid polyethylene glycol and encapsulated in a soft gelatin capsule shell, in which the capsule shell comprises gelatin, a plasticizer therefor, and an embrittlement inhibiting composition comprising a mixture of sorbitol and at least one sorbitan. Preferably the polyethylene glycol also contains glycerin, sorbitol or propylene glycol.Type: GrantFiled: October 1, 1986Date of Patent: October 25, 1988Assignee: R.P. Scherer CorporationInventor: Werner Brox
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Patent number: 4744988Abstract: A soft gelatin capsule comprising a shell of gelatin and a softener, and a filling consisting of a polyethylene glycol and a low polyhydric alcohol and at least one active substance, characterized in that(a) the dried shell of the capsule contains 4 to 40% by weight of sorbital or sorbitanes;(b) at least 50% by weight of the polyethylene glycol used in the filling for dissolving or suspending the active substance is a polyethylene glycol having a mean molecular weight of 600; and(c) the capsule filling comprises up to 20% by weight of glycerol and/or 1,2-propylene glycol.Type: GrantFiled: December 17, 1986Date of Patent: May 17, 1988Assignee: R. P. Scherer CorporationInventor: Werner Brox