Patents by Inventor Werner Constant Johan Embrechts

Werner Constant Johan Embrechts has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF
    Publication number: 20230278964
    Abstract: This application relates to quinazoline derivatives, processes for their preparation, pharmaceutical compositions, and medical uses thereof.
    Type: Application
    Filed: January 24, 2023
    Publication date: September 7, 2023
    Inventors: David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Jérôme Émile Georges GUILLEMONT, Ludwig Paul COOYMANS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie RABOISSON
  • 2,4-diaminoquinazoline derivatives and medical uses thereof
    Patent number: 11597704
    Abstract: This application relates to quinazoline derivatives of formula (I), pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds of formula (I) in the treatment or prevention of a viral infection, of a virus-induced disease, of cancer or of an allergy.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: March 7, 2023
    Assignee: JANSSEN SCIENCES IRELAND UNLIMITED COMPANY
    Inventors: David Craig Mc Gowan, Werner Constant Johan Embrechts, Jérôme Émile Georges Guillemont, Ludwig Paul Cooymans, Tim Hugo Maria Jonckers, Pierre Jean-Marie Raboisson
  • PYRAZOLYL QUINOXALINE KINASE INHIBITORS
    Publication number: 20220135544
    Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: October 20, 2021
    Publication date: May 5, 2022
    Applicant: ASTEX THERAPEUTICS LTD
    Inventors: Gordon SAXTY, Christopher William Murray, Valerio Berdini, Gilbert Ebai Besong, Christopher Charles Frederick Hamlett, Christopher Norbert Johnson, Steven John Woodhead, Michael Reader, David Charles Rees, Laurence Anne Mevellec, Patrick René Angibaud, Eddy Jean Edgard Freyne, Tom Cornelis Hortense Govaerts, Johan Erwin Edmond Weerts, Timothy Pietro Suren Perera, Ronaldus Arnodus Hendrika Joseph Gilissen, Berthold Wroblowski, Jean Fernand Armand Lacrampe, Alexandra Papanikos, Olivier Alexis Georges Querolle, Elisabeth Thérèse Jeanne Pasquier, Isabelle Noëlle Constance Pilatte, Pascal Ghislain André Bonnet, Werner Constant Johan Embrechts, Rhalid Akkari, Lieven Meerpoel
  • DIHYDROPYRANOPYRIMIDINES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20210387997
    Abstract: This invention relates to dihydropyranopyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: June 23, 2021
    Publication date: December 16, 2021
    Inventors: Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Jérôme Émile Georges GUILLEMONT, David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Ludwig Paul COOYMANS, Laurent CALMUS
  • PYRIMIDINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
    Publication number: 20210214317
    Abstract: This invention relates to pyrimidine prodrug derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Application
    Filed: March 25, 2021
    Publication date: July 15, 2021
    Inventors: Jérôme Émile Georges GUILLEMONT, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Bart Henri Theresia STOOPS, Florence Marie HERSCHKE, Jacques Armand Henri BOLLEKENS, Laurent Jacques Emile CALMUS
  • Dihydropyranopyrimidines for the treatment of viral infections
    Patent number: 11053256
    Abstract: This invention relates to dihydropyranopynmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: July 6, 2021
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Jérôme Émile Georges Guillemont, David Craig McGowan, Werner Constant Johan Embrechts, Ludwig Paul Cooymans, Laurent Calmus
  • Pyrimidine prodrugs for the treatment of viral infections and further diseases
    Patent number: 10968184
    Abstract: This invention relates to pyrimidine prodrug derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Grant
    Filed: September 28, 2017
    Date of Patent: April 6, 2021
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: Jérôme Émile Georges Guillemont, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, David Craig McGowan, Werner Constant Johan Embrechts, Bart Henri Theresia Stoops, Florence Marie Herschke, Jacques Armand Henri Bollekens, Laurent Jacques Emile Calmus
  • 2,4-DIAMINOQUINAZOLINE DERIVATIVES AND MEDICAL USES THEREOF
    Publication number: 20210040046
    Abstract: This application relates to quinazoline derivatives of formula (I), pharmaceutical compositions comprising the compounds of formula (I), and the use of the compounds of formula (I) in the treatment or prevention of a viral infection, of a virus-induced disease, of cancer or of an allergy.
    Type: Application
    Filed: February 28, 2019
    Publication date: February 11, 2021
    Applicant: Janssen Sciences Ireland Unlimi
    Inventors: David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Jérôme Émile Georges GUILLEMONT, Ludwig Paul COOYMANS, Tim Hugo Maria JONCKERS, Pierre Jean-Marie RABOISSON
  • PYRAZOLYL QUINOXALINE KINASE INHIBITORS
    Publication number: 20200131153
    Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: October 25, 2019
    Publication date: April 30, 2020
    Applicant: ASTEX THERAPEUTICS LTD
    Inventors: Gordon SAXTY, Christopher William MURRAY, Valerio BERDINI, Gilbert Ebai BESONG, Christopher Charles Frederick HAMLETT, Christopher Norbert JOHNSON, Steven John WOODHEAD, Michael READER, David Charles REES, Laurence Anne MEVELLEC, Patrick René ANGIBAUD, Eddy Jean Edgard FREYNE, Tom Cornelis Hortense GOVAERTS, Johan Erwin Edmond WEERTS, Timothy Pietro Suren PERERA, Ronaldus Arnodus Hendrika Joseph GILISSEN, Berthold WROBLOWSKI, Jean Fernand Armand LACRAMPE, Alexandra PAPANIKOS, Olivier Alexis Georges QUEROLLE, Elisabeth Thérèse Jeanne PASQUIER, Isabelle Noëlle Constance PILATTE, Pascal Ghislain André BONNET, Werner Constant Johan EMBRECHTS, Rhalid AKKARI, Lieven MEERPOEL
  • Heterocyclic indoles for use in influenza virus infection
    Patent number: 10626108
    Abstract: The current invention relates to a compound of formula (I) which can be used for the treatment of, or against viral influenza infections.
    Type: Grant
    Filed: November 25, 2016
    Date of Patent: April 21, 2020
    Assignee: JANSSEN SCIENCES IRELAND UC
    Inventors: Tim Hugo Maria Jonckers, David Craig McGowan, Jérôme Émile Georges Guilllemont, Ludwig Paul Cooymans, Werner Constant Johan Embrechts, Christophe Francis Robert Nestor Buyck, Wendy Mia Albert Balemans, Pierre Jean-Marie Bernard Raboisson
  • Indoles for use in influenza virus infection
    Patent number: 10597390
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Grant
    Filed: August 7, 2015
    Date of Patent: March 24, 2020
    Assignee: Janssen Sciences Ireland UC
    Inventors: Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson, Jérôme Émile Georges Guillemont, David Craig McGowan, Werner Constant Johan Embrechts, Ludwig Paul Cooymans, Antoine Benjamin Michaut
  • PYRIMIDINE PRODRUGS FOR THE TREATMENT OF VIRAL INFECTIONS AND FURTHER DISEASES
    Publication number: 20200031779
    Abstract: This invention relates to pyrimidine prodrug derivatives, processes for their preparation, pharmaceutical compositions, and their use in therapy.
    Type: Application
    Filed: September 28, 2017
    Publication date: January 30, 2020
    Inventors: Jérôme Émile Georges GUILLEMONT, Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Bart Henri Theresia STOOPS, Florence Marie HERSCHKE, Jacques Armand Henri BOLLEKENS, Laurent Jacques Emile CALMUS
  • Pyrazolyl quinoxaline kinase inhibitors
    Patent number: 10519137
    Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: December 31, 2019
    Assignee: ASTEX THERAPEUTICS LTD
    Inventors: Gordon Saxty, Christopher William Murray, Valerio Berdini, Gilbert Ebai Besong, Steven John Woodhead, Michael Reader, Laurence Anne Mevellec, Patrick René Angibaud, Eddy Jean Edgard Freyne, Timothy Pietro Suren Perera, Berthold Wroblowski, Alexandra Papanikos, Olivier Alexis Georges Querolle, Isabelle Noëlle Constance Pilatte, Pascal Ghislain André Bonnet, Werner Constant Johan Embrechts, Rhalid Akkari, Lieven Meerpoel
  • DIHYDROPYRANOPYRIMIDINES FOR THE TREATMENT OF VIRAL INFECTIONS
    Publication number: 20190322678
    Abstract: This invention relates to dihydropyranopynmidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treating viral infections.
    Type: Application
    Filed: June 30, 2017
    Publication date: October 24, 2019
    Applicant: Janssen Sciences Ireland Unlimited Company
    Inventors: Tim Hugo Maria JONCKERS, Pierre Jean-Marie Bernard RABOISSON, Jérôme Émile Georges GUILLEMONT, David Craig MC GOWAN, Werner Constant Johan EMBRECHTS, Ludwig Paul COOYMANS, Laurent CALMUS
  • Macrocyclic quinazole derivatives and their use as MTKI
    Patent number: 10208062
    Abstract: The present invention concerns the compounds of formula the N-oxide forms, the pharmaceutically acceptable addition salts and the stereochemically isomeric forms thereof, wherein Z represents NH; Y represents —C3-9alkyl-, —C1-5alkyl-NR13—C1-5alkyl-, —C1-5alkyl-NR14—CO—C1-5alkyl-, —C1-2alkyl-NR21—H2—CO—NH—C1-3alkyl- or —C1-2alkyl-NR23—CO—CR16R17—NH—; X1 represents O or —O—C1-2alkyl-; X2 represents a direct bond, C1-2alkyl, —CO—C1-2alkyl or NR12—C1-2alkyl; R1 represents hydrogen or halo; R2 represents halo, acetylene or Het1 R3 represents hydrogen or cyano; R4 represents Ar4—C1-4alkyloxy-, C1-4alkyloxy- or C1-4alkyloxy substituted with one or where possible two or more substituents selected from Het2, NR7R8, hydroxy and C1-4alkyloxy-C1-4alkyloxy-; R7 represents hydrogen or C1-4alkyl; R8 represents C1-4alkyl substituted with NR25R26 or C1-4alkylsulfonyl; R12 represents hydrogen or C1-4alkyl-; R13 represents Ar6-sulfonyl or C1-6alkyloxycarbonyl optionally substituted with phenyl; R16 and R17 represents hydr
    Type: Grant
    Filed: May 22, 2017
    Date of Patent: February 19, 2019
    Assignee: Janssen Pharmaceutica NV
    Inventors: Eddy Jean Edgard Freyne, Marc Willems, Peter Ten Holte, Alexandra Papanikos, Werner Constant Johan Embrechts, Pierre Henri Storck, Virginie Sophie Poncelet
  • HETEROCYCLIC INDOLES FOR USE IN INFLUENZA VIRUS INFECTION
    Publication number: 20180258074
    Abstract: The current invention relates to a compound of formula (I) which can be used for the treatment of, or against viral influenza infections.
    Type: Application
    Filed: November 25, 2016
    Publication date: September 13, 2018
    Inventors: Tim Hugo Maria JONCKERS, David Craig MCGOWAN, Jérôme Émile George GUILLLEMONT, Ludwig Paul COOYMANS, Werner Constant Johan EMBRECHTS, Christophe Francis Robert Nest BUYCK, Wendy Mia Albert BALEMANS, Pierre Jean-Marie Bernard RABOISSON
  • Macrocylic pyrimidine derivatives
    Patent number: 10017509
    Abstract: The present invention relates to substituted macrocylic pyrimidine derivatives of Formula (I) wherein the variables have the meaning defined in the claims. The compounds according to the present invention have EF2K inhibitory activity and optionally also Vps34 inhibitory activity. The invention further relates to processes for preparing such novel compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament.
    Type: Grant
    Filed: April 2, 2015
    Date of Patent: July 10, 2018
    Assignee: Janssen Pharmaceutica NV
    Inventors: Gaston Stanislas Marcella Diels, Bruno Schoentjes, Matthias Luc Aime Versele, Didier Jean-Claude Berthelot, Marc Willems, Marcel Viellevoye, Werner Constant Johan Embrechts, Berthold Wroblowski, Lieven Meerpoel
  • PYRAZOLYL QUINOXALINE KINASE INHIBITORS
    Publication number: 20180127397
    Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Application
    Filed: November 13, 2017
    Publication date: May 10, 2018
    Applicant: ASTEX THERAPEUTICS LTD
    Inventors: Gordon SAXTY, Christopher William MURRAY, Valerio BERDINI, Gilbert Ebai BESONG, Christopher Charles Frederick HAMLETT, Christopher Norbert JOHNSON, Steven John WOODHEAD, Michael READER, David Charles REES, Laurence Anne MEVELLEC, Patrick René ANGIBAUD, Eddy Jean Edgard FREYNE, Tom Cornelis Hortense GOVAERTS, Johan Erwin Edmond WEERTS, Timothy Pietro Suren PERERA, Ronaldus Arnodus Hendrika Joseph GILISSEN, Berthold WROBLOWSKI, Jean Fernand Armand LACRAMPE, Alexandra PAPANIKOS, Olivier Alexis Georges QUEROLLE, Elisabeth Thérèse Jeanne PASQUIER, Isabelle Noëlle Constance PILATTE, Pascal Ghislain André BONNET, Werner Constant Johan EMBRECHTS, Rhalid AKKARI, Lieven MEERPOEL
  • Pyrrolopyrimidines for use in influenza virus infection
    Patent number: 9932346
    Abstract: The invention relates to compounds having the structure of formula (I) which can be used for the treatment of or against influenza infections.
    Type: Grant
    Filed: September 7, 2015
    Date of Patent: April 3, 2018
    Assignee: Janssen Sciences Ireland UC
    Inventors: Tim Hugo Maria Jonckers, David Craig McGowan, Pierre Jean-Marie Bernard Raboisson, Werner Constant Johan Embrechts, Jérôme Émile Georges Guillemont
  • Pyrazolyl quinoxaline kinase inhibitors
    Patent number: 9850228
    Abstract: The invention relates to new quinoxaline derivative compounds, to pharmaceutical compositions comprising said compounds, to processes for the preparation of said compounds and to the use of said compounds in the treatment of diseases, e.g. cancer.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: December 26, 2017
    Assignee: ASTEX THERAPEUTICS LTD
    Inventors: Gordon Saxty, Christopher William Murray, Valerio Berdini, Gilbert Ebai Besong, Christopher Charles Frederick Hamlett, Christopher Norbert Johnson, Steven John Woodhead, Michael Reader, David Charles Rees, Laurence Anne Mevellec, Patrick René Angibaud, Eddy Jean Edgard Freyne, Tom Cornelis Hortense Govaerts, Johan Erwin Edmond Weerts, Timothy Pietro Suren Perera, Ronaldus Arnodus Hendrika Joseph Gilissen, Berthold Wroblowski, Jean Fernand Armand Lacrampe, Alexandra Papanikos, Olivier Alexis Georges Querolle, Elisabeth Thérèse Jeanne Pasquier, Isabelle Noëlle Constance Pilatte, Pascal Ghislain André Bonnet, Werner Constant Johan Embrechts, Rhalid Akkari, Lieven Meerpoel