Patents by Inventor Werner Guethlein

Werner Guethlein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5274095
    Abstract: Diarylimidazoles of the general formula: ##STR1## wherein R.sup.1 is a radical of the general formula: ##STR2## in which R.sup.3 and R.sup.6 are hydrogen atoms, R.sup.4 and R.sup.5, which can be the same or different, are lower alkyl radicals or R.sup.3 /R.sup.4 and /or R.sup.5 /R.sup.6 in each case together represent a lower alkylene radical and R.sup.2 is a lower alkyl radical, and/or of a salt thereof, are useful as redox indicators, particularly in the presence of a SH group-containing substance.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: December 28, 1993
    Assignee: Boehringer Mannheim GmbH
    Inventors: Hans-Peter Braun, Ulfert Deneke, Werner Guethlein, Rolf Nagel
  • Patent number: 5215924
    Abstract: The invention relates to a method for determining an ion in an aqueous sample. The method involves contacting the sample with a water immiscible material including an ionophore, a pH indicator and a compound which stabilizes sensitivity of the assay. The ion reacts with the ionophore in the water immiscible material, releasing a proton which reacts with the pH indicator generating a color change which is representative of the ion to be measured. The stabilizing compound stabilizes this change. Also described are compositions including the three recited elements, and various new compounds useful as the stabilizer.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: June 1, 1993
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter Rittersdorf, Werner Guethlein, Detlef Thym, Peter Vogel
  • Patent number: 5194389
    Abstract: The subject matter of the present invention are naphthol derivatives having the general formula I ##STR1## in which R.sup.1, R.sup.2, R.sup.3 are the same or different and each represents hydrogen, an alkyl or alkoxy group, in which at least one of the residues is a (C.sub.8 -C.sub.30)-alkyl or alkoxy residueR.sup.4 is hydrogen or an alkyl groupR.sup.5 is a nitro group, an alkyl group substituted by halogen, a cyano group, a sulfonamide group or an alkylsulfonyl groupX is nitrogen or the residue CR.sup.6 andY is sulphur or the residue CR.sup.7 =CR.sup.8in which R.sup.6, R.sup.7, R.sup.8 are the same or different and each denotes hydrogen, halogen, a nitro group, a cyano group, an alkyl or an alkyl group substituted by halogen or an alkylsulfonyl group, a process for their production and their use as a pH indicator or in methods and agents for the determination of an ion in an aqueous liquid.
    Type: Grant
    Filed: May 10, 1991
    Date of Patent: March 16, 1993
    Assignee: Boehringer Mannheim GmbH
    Inventors: Walter Rittersdorf, Werner Guethlein, Peter Vogel, Detlef Thym
  • Patent number: 5162200
    Abstract: Diarylimidazoles of the general formula: ##STR1## wherein R.sup.1 is a radical of the general formula: ##STR2## in which R.sup.3 and R.sup.6 are hydrogen atoms, R.sup.4 and R.sup.5, which can be the same or different, are lower alkyl radicals or R.sup.3 /R.sup.4 and/or R.sup.5 /R.sup.6 in each case together represent a lower alkylene radical and R.sup.2 is a lower alkyl radical, and/or of a salt thereof, are used as redox indicators in the colorimetric diarylimidazoles are not influenced by the presence of a SH group-containing substance. The peroxidate-acting substance can be used to determine the presence of creatine kinase.
    Type: Grant
    Filed: May 30, 1990
    Date of Patent: November 10, 1992
    Assignee: Boehringer Manneheim GmbH
    Inventors: Hans-Peter Braun, Ulfert Deneke, Werner Guethlein, Rolf Nagel
  • Patent number: 4985414
    Abstract: New 1-naphtholphthalein monophosphates of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 is hydrogen or halogen, and each of M.sup.1 and M.sup.2 is a proton or an alkali metal, alkaline earth metal, ammonium, dicyclohexylammonium, tetraalkylammonium or alkanolammonium cation, and the tautomeric transformation products thereof, are useful as substrates for detection and photometric determination of alkaline phosphotase.
    Type: Grant
    Filed: November 18, 1988
    Date of Patent: January 15, 1991
    Assignee: Boehringer Mannheim GmbH
    Inventors: Werner Guethlein, Hartmut Merdes