Patents by Inventor Werner Hafelfinger
Werner Hafelfinger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11234702Abstract: Interatrial shunts having incorporated physiologic sensors are provided for monitoring and treating cardiovascular syndromes, including heart failure and pulmonary hypertension, in which the one or more sensors are affixed to the shunt to measure a physiologic parameter within the interatrial shunt. The one or more sensors may be directly affixed to or within a lumenal surface of the shunt or may be disposed on a support structure in a spaced relation to the shunt lumen, the one or more sensors disposed at locations subject to little or no pannus formation or cardiac wall motion artifact.Type: GrantFiled: November 13, 2020Date of Patent: February 1, 2022Assignee: V-Wave Ltd.Inventors: Neal Eigler, Erez Rozenfeld, Nir Nae, Nathan Bukhdruker, Lior Rosen, James S. Whiting, John Wardle, Werner Hafelfinger
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Publication number: 20210393421Abstract: Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilatation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium.Type: ApplicationFiled: September 2, 2021Publication date: December 23, 2021Applicant: V-Wave Ltd.Inventors: Lior ROSEN, Neal EIGLER, Erez ROZENFELD, Nir NAE, Werner HAFELFINGER, Yeela SCOP
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Publication number: 20210338990Abstract: Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.Type: ApplicationFiled: November 6, 2020Publication date: November 4, 2021Applicant: V-Wave Ltd.Inventors: Neal EIGLER, Nir NAE, Nathan BUKHDRUKER, James S. WHITING, Lior ROSEN, Erez ROZENFELD, Werner HAFELFINGER
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Patent number: 11109988Abstract: Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilatation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium.Type: GrantFiled: October 30, 2017Date of Patent: September 7, 2021Assignee: V-Wave Ltd.Inventors: Lior Rosen, Neal Eigler, Erez Rozenfeld, Nir Nae, Werner Hafelfinger, Yeela Scop
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Publication number: 20210161637Abstract: Systems and methods for implanting a shunt for regulating blood pressure between a patient's left and right atria are provided. The shunt comprises an anchor having a neck region, first and second end regions, and a conduit affixed with the anchor formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism. The shunt may be advanced through the sheath until the first region protrudes from the sheath and self-expands within the left atrium. The shunt and the sheath may then be retracted until the first region contacts the left side of the atrial septum. The sheath may further be retracted until the counterforce exerted by shunt tension on the atrial septum overcomes the friction of the retained portions of the shunt such that the second region is exposed from the sheath and self-expands within the second atrium.Type: ApplicationFiled: February 12, 2021Publication date: June 3, 2021Applicant: V-Wave Ltd.Inventors: Neal EIGLER, Nir NAE, Lior ROSEN, Werner HAFELFINGER, Erez ROZENFELD, James S. WHITING, Menashe YACOBY, Yaacov NITZAN
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Publication number: 20210100665Abstract: Systems and methods for the manufacture of an hourglass shaped stent-graft assembly having an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium. The encapsulated stents may also be used to treat pulmonary hypertension.Type: ApplicationFiled: November 11, 2020Publication date: April 8, 2021Applicant: V-Wave Ltd.Inventors: Nir NAE, Lior ROSEN, Neal EIGLER, Erez ROZENFELD, Werner HAFELFINGER, Yeela SCOP
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Patent number: 10925706Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.Type: GrantFiled: September 13, 2018Date of Patent: February 23, 2021Assignee: V-Wave Ltd.Inventors: Neal Eigler, Lior Rosen, Werner Hafelfinger, Erez Rozenfeld, Tamir Ben-David, Nir Nae, Menashe Yacoby, Yaacov Nitzan
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Patent number: 10898698Abstract: Devices are provided with an internal dimension that can be reduced and increased in vivo. In one example, an interatrial shunt for placement at an atrial septum of a patient's heart includes a body. The body includes first and second regions coupled in fluid communication by a neck region. The body includes a shape-memory material. The body defines a passageway through the neck region for blood to flow between a first atrium and a second atrium. The first and second regions are superelastic at body temperature, and the neck region is malleable at body temperature. A flow area of the passageway through the neck region may be adjusted in vivo.Type: GrantFiled: May 15, 2020Date of Patent: January 26, 2021Assignee: V-Wave Ltd.Inventors: Neal Eigler, Nir Nae, Nathan Bukhdruker, James S. Whiting, Lior Rosen, Erez Rozenfeld, Werner Hafelfinger
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Publication number: 20210000581Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.Type: ApplicationFiled: September 13, 2018Publication date: January 7, 2021Applicant: V-Wave Ltd.Inventors: Neal EIGLER, Lior ROSEN, Werner HAFELFINGER, Erez ROZENFELD, Tamir BEN-DAVID, Nir NAE, Menashe YACOBY, Yaacov NITZAN
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Publication number: 20200368505Abstract: A device for precise control of blood flow across an interatrial septum is provided. The device includes a sheath having a first set of openings disposed within a first atrium while a second set of openings is disposed within a second atrium. An actuator may be actuated to move an inner sleeve within the sheath to modify the area of second set of openings to permit blood to flow between the first and second atria responsive to a pressure gradient across the interatrial septum via the first and second openings at a blood flow rate corresponding with the area of the second set of openings of the sheath. In addition, the patient's hemodynamics responsive to the shunting of blood across the interatrial septum at each incremental area of the opening may be monitored for selecting a specific sized implantable interatrial shunt for the patient.Type: ApplicationFiled: May 18, 2020Publication date: November 26, 2020Applicant: V-Wave Ltd.Inventors: Nir NAE, Tal WEISINGER, Lior ROSEN, James WHITING, Neal EIGLER, Werner HAFELFINGER, Erez ROZENFELD
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Patent number: 10835394Abstract: Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium. The encapsulated stents may also be used to treat pulmonary hypertension.Type: GrantFiled: November 29, 2018Date of Patent: November 17, 2020Assignee: V-Wave, Ltd.Inventors: Nir Nae, Lior Rosen, Neal Eigler, Erez Rozenfeld, Werner Hafelfinger, Yeela Scop
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Publication number: 20200078196Abstract: Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilatation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium.Type: ApplicationFiled: October 30, 2017Publication date: March 12, 2020Inventors: Lior ROSEN, Neal EIGLER, Erez ROZENFELD, Nir NAE, Werner HAFELFINGER, Yeela SCOP
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Publication number: 20190298516Abstract: A fixation device for securing together leaflets of a heart valve is provided. The fixation device may comprise two plates that are disposed on either side of the tricuspid valve. The plates may be secured to one another by a locking clip, thereby securing the valve leaflets between the plates.Type: ApplicationFiled: July 22, 2016Publication date: October 3, 2019Inventors: Robert James Siegel, Lawrence Eric Ong, Werner Hafelfinger, Niclas Henning Zieger
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Publication number: 20190110911Abstract: Systems and methods for the manufacture of an hourglass shaped stent-graft assembly comprising an hourglass shaped stent, graft layers, and an assembly mandrel having an hourglass shaped mandrel portion. Hourglass shaped stent may have superelastic and self-expanding properties. Hourglass shaped stent may be encapsulated using hourglass shaped mandrel assembly coupled to a dilation mandrel used for depositing graft layers upon hourglass shaped mandrel assembly. Hourglass shaped mandrel assembly may have removably coupled conical portions. The stent-graft assembly may be compressed and heated to form a monolithic layer of biocompatible material. Encapsulated hourglass shaped stents may be used to treat subjects suffering from heart failure by implanting the encapsulated stent securely in the atrial septum to allow blood flow from the left atrium to the right atrium when blood pressure in the left atrium exceeds that on the right atrium. The encapsulated stents may also be used to treat pulmonary hypertension.Type: ApplicationFiled: November 29, 2018Publication date: April 18, 2019Applicant: V-Wave Ltd.Inventors: Nir NAE, Lior ROSEN, Neal EIGLER, Erez ROZENFELD, Werner HAFELFINGER, Yeela SCOP
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Patent number: 10251740Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.Type: GrantFiled: September 13, 2018Date of Patent: April 9, 2019Assignee: V-Wave Ltd.Inventors: Neal Eigler, Lior Rosen, Werner Hafelfinger, Erez Rozenfeld, Tamir Ben-David, Nir Nae, Menashe Yacoby, Yaacov Nitzan
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Publication number: 20190015188Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.Type: ApplicationFiled: September 13, 2018Publication date: January 17, 2019Applicant: V-Wave Ltd.Inventors: Neal EIGLER, Lior ROSEN, Werner HAFELFINGER, Erez ROZENFELD, Tamir BEN-DAVID, Nir NAE, Menashe YACOBY, Yaacov NITZAN
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Publication number: 20190008628Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.Type: ApplicationFiled: September 13, 2018Publication date: January 10, 2019Inventors: Neal EIGLER, Lior ROSEN, Werner HAFELFINGER, Erez ROZENFELD, Tamir BEN-DAVID, Nir NAE, Menashe YACOBY, Yaacov NITZAN
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Patent number: 10076403Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.Type: GrantFiled: March 3, 2017Date of Patent: September 18, 2018Assignee: V-Wave Ltd.Inventors: Neal Eigler, Lior Rosen, Werner Hafelfinger, Erez Rozenfeld, Tamir Ben-David, Nir Nae, Menashe Yacoby, Yaacov Nitzan
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Publication number: 20180243071Abstract: A shunt for regulating blood pressure between a patient's left atrium and right atrium comprises an anchor comprising a neck region, first and second end regions, and a conduit affixed with the anchor that formed of a biocompatible material that is resistant to transmural and translation tissue ingrowth and that reduces a risk of paradoxical embolism.Type: ApplicationFiled: March 3, 2017Publication date: August 30, 2018Applicant: V-Wave Ltd.Inventors: Neal EIGLER, Lior ROSEN, Werner HAFELFINGER, Erez ROZENFELD, Tamir BEN-DAVID, Nir NAE, Menashe YACOBY, Yaacov Nitzan
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Patent number: 9918677Abstract: This invention relates generally to systems and methods for optimizing the performance and minimizing complications related to implanted sensors, such as pressure sensors, for the purposes of detecting, diagnosing and treating cardiovascular disease in a medical patient. Systems and methods for anchoring implanted sensors to various body structures is also provided.Type: GrantFiled: June 23, 2015Date of Patent: March 20, 2018Assignee: Pacesetter, Inc.Inventors: Neal L. Eigler, Brian M. Mann, James S. Whiting, Werner Hafelfinger