Abstract: The present invention provides compositions comprising a substance of a particle size between 1 ?m and 100 ?m and a solubility in water between 0.0001 g/l and 10 g/l, at least 2 wt % of at least one cellulose based polymer, at least one anionic surfactant, at least one non-ionic surfactant, wherein the non-ionic surfactant is present in an amount of non-ionic surfactant to at least one cellulose based polymer in the range of between 10:1 and 1:10, wherein the ratio of the at least one cellulose based polymer and the at least one non-ionic surfactant together to the substance is between 2:1 to 1:2, and wherein the concentration of the substance of a particle size between 1 ?m and 100 ?m and a solubility in water between 0.0001 g/l and 10 g/l is in the range of 10.1 wt % to 15 wt %. The present invention also provides methods of manufacturing the compositions.

Abstract: The present invention relates to an enteric coated pharmaceutical composition comprising a solid dispersion comprising regorafenib and at least one stabilizing agent outside of the solid dispersion, its process of preparation and its use for treating disorders.

Abstract: Disclosed herein is a method for the preparation of an amorphous solid dispersion (ASD) comprising the steps of providing an aqueous suspension comprising nano-particles having a solubility in the aqueous suspension of less than 10 g/1, water and at least one polymer, nano-dry-melting of the aqueous suspension comprising nano-particles for a time span between 0.1 seconds and 300 seconds, at a temperature between a) 20 K below the glass transition temperature as determined with DSC according to DIN EN ISO 11357-2 at a heating rate of 10 K/min of the solid components of the aqueous suspension comprising nano-particles or 20 K below the glass transition temperature of the at least one polymer, depending on what is higher, b) the decomposition temperature of the at least one polymer or the decomposition temperature of the nano-particles, depending which is lower to form the amorphous solid dispersion.

Abstract: The present invention relates to stable nanosuspensions of methyl {4,6-diamino-2-[5-fluoro-1-(2- fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate (Vericiguat, compound of formula (I)), processes for preparing the stable nanosuspensions, nanoparticles comprising the compound of formula (I), and pharmaceutical compositions in solid form made from the nanosuspensions.

Abstract: A process for the preparation of a nanoparticulate active ingredient comprises the steps of: a) providing a solvent, a pharmaceutical active ingredient dissolved in the solvent, a liquid antisolvent and a stabilizer which is dissolved in the solvent or in the antisolvent and wherein the antisolvent is miscible in the solvent; b) mixing the solvent, the active ingredient, the antisolvent and the stabilizer in a micromixer, thereby obtaining a suspension comprising a precipitate of the active ingredient, the solvent and the antisolvent. The active ingredient precipitate is present in the form of nanoparticles having an average particle size of ?10 nm to ?999 nm and a particle size distribution, determined by dynamic light scattering (DLS) according to ISO 22412:2017, having a polydispersity index of ?0.2.

Abstract: A process for producing a pharmaceutical formulation comprises the steps of: A) suspending a pharmaceutical active substance in an aqueous solution of a polymer; B) drying the mixture obtained in step A); wherein in step A) the pharmaceutical active substance is present in the form of particles having a d90 value in the particle size distribution of ?1 ?m and before step B) the pharmaceutical active substance is further contacted with an ionic surfactant.

Abstract: A process for producing a pharmaceutical formulation comprising the steps of: A) providing particles of a polymer, wherein particles of a pharmaceutical active substance are additionally at least partially embedded in the particles of the polymer; B) heating the particles of the polymer to a predetermined temperature for a predetermined time and C) cooling the particles of the polymer after the predetermined time to a temperature of 18° C. to 24° C., wherein the polymer is at least partially soluble in water and the active substance is at least partially soluble in the polymer. The particulate pharmaceutical active substance is present in the form of particles having a d90 value in the particle size distribution of ?1 ?m. The predetermined temperature is within a range from 10 K below the glass transition temperature (determined by DSC in accordance with DIN EN ISO 11357-2 at a heating rate of 10 K/min) of the polymer to the melting temperature of the active substance.

Abstract: The invention relates to an illumination device for illuminating at least one light modulator system of a liquid crystal display, the device comprising at least one waveguide substrate for guiding at least one targeted light beam that can be coupled into the waveguide substrate. The waveguide substrate is at least in optical contact with at least one holographic optical decoupling substrate comprising a plurality of decoupling regions and a decoupling region is at least designed to decouple part of the targeted light beam in the form of a plurality of sub-beams in the direction of the light modulator system. At least one diffuser module is provided, said diffuser module being designed in such a way that at least the outermost sub-beams of two neighboring decoupling regions are at least adjacent to one another before exiting the diffuser module.

Abstract: The invention relates to a continuous-flow synthesis process for the preparation of high quality indium phosphide/zinc sulfide core/shell semiconduting nanocrystals in particular quantum dots (QD) conducted in a micro-reaction system comprising at least one mixing chamber connected to one reaction chamber.

Abstract: The invention relates to a continuous-flow synthesis process for the preparation of high quality indium phosphide/zinc sulfide core/shell semiconduting nanocrystals in particular quantum dots (QD) conducted in a micro-reaction system comprising at least one mixing chamber connected to one reaction chamber.

Abstract: The invention relates to a dispersion comprising a dispersion medium, a polymeric dispersing agent, and carbon nanotubes dispersed in the dispersion medium. The proportion of carbon nanotubes present in the form of agglomerates with an average agglomerate size of >=1 [mu]m to the total quantity of carbon nanotubes <=10 vol %, and >=70% of the carbon nanotubes which are not present in the agglomerated form have a length of >=200 nm. the invention further relates to a method for producing such a dispersion, to a method for producing an electrode with the dispersion, to an electrode obtained in this manner, and to an electrochemical element containing the electrode.

Abstract: The invention relates to a planar light distribution module for a display, comprising a light guide plate through which light coupled in via at least one side face can propagate by means of total reflection, and at least one out-coupling device (2), which is applied on one or both of the main faces of the light guide plate (1), is in optical contact therewith and has a multiplicity of holographic optical elements (13) formed therein, which are configured in such a way that they can couple light out of the light guide plate (1), the light distribution module being characterized in that the holographic optical elements (13), independently of one another, have an extent of at least 300 ?m in at least one spatial axis extending parallel to the surface of the out-coupling device (2). The invention furthermore relates to an optical display, in particular an electronic display.

Abstract: The invention relates to a planar light distribution module for a display, comprising a light guide plate through which light coupled in via at least one side face can propagate by means of total reflection, and at least one planar out-coupling device (2), which is applied on one or both of the main faces of the light guide plate (1), is in optical contact therewith and has a multiplicity of holographic optical elements (13) formed therein, which are configured in such a way that they can couple light out of the light guide plate (1), the light distribution module being characterized in that the holographic optical elements (13) are arranged in the out-coupling device (2) without translational symmetry. The invention furthermore relates to an optical display, in particular an electronic display, which contains a light distribution module according to the invention.

Abstract: The invention relates to an illumination device for illuminating at least one light modulator system of a liquid crystal display, the device comprising at least one waveguide substrate for guiding at least one targeted light beam that can be coupled into the waveguide substrate. The waveguide substrate is at least in optical contact with at least one holographic optical decoupling substrate comprising a plurality of decoupling regions and a decoupling region is at least designed to decouple part of the targeted light beam in the form of a plurality of sub-beams in the direction of the light modulator system. At least one diffuser module is provided, said diffuser module being designed in such a way that at least the outermost sub-beams of two neighbouring decoupling regions are at least adjacent to one another before exiting the diffuser module.

Abstract: The invention relates to a continuous-flow synthesis process for the preparation of high quality indium phosphide/zinc sulfide core/shell semiconduting nanocrystals in particular quantum dots (QD) conducted in a micro-reaction system comprising at least one mixing chamber connected to one reaction chamber.

Abstract: Nanoparticles having a hydrophilic surface coatings having biological, molecular biological, biochemical and medical applications, and method for their production.

Abstract: The present invention relates to a method for treatment of semiconducting nanoparticles wherein in a step A semiconducting nanoparticles comprising long chain insulting primary ligands are dispersed in a volatile dispersion solvent capable of dissolving insulating primary ligands and precipitated using a washing agent. TGA-MS analysis shows that the treatment according to the method of the present invention allows complete removal of the outer layer of synthesis ligands of the surface of prepared nanoparticles and improves removal of synthesis ligands on the surface of prepared nanoparticles. The present invention also relates to semiconducting nanoparticles, ink formulation and electronic devices comprising the semiconducting nanoparticles obtainable by the procedure of the invention.

Abstract: Process for producing metal particle sols having a metal particle content of ?1 g/l, comprising the steps of a) reacting a metal salt solution with a solution containing hydroxide ions b) reacting the solution obtained from step a) with a reducing agent, wherein at least one of the solutions in step a) comprises a dispersing assistant, metal particles produced by the process and the use thereof.

Abstract: Luminescent inorganic nanoparticles comprising: (a) a core made from a first metal salt or oxide being surrounded by (b) a shell made from a second metal salt or oxide being luminescent and having non-semiconductor properties. These nanoparticles can be advantageously used in (fluorescence) resonance energy transfer ((F)RET)-based bioassays in view of their higher (F)RET efficiency.

Abstract: The present invention relates to nanoparticles having a hydrophilic surface coating, to methods of production thereof and to the use thereof in biological, molecular biological, biochemical and medical applications.