Abstract: A method for cleaning primary packaging means in pharmaceutical filling and/or packaging installations. The method includes a step of treating at least one surface of the primary packaging by means of blasting with carbon dioxide (CO2) snow, a step of using a gas flow for the suction extraction of substances cleaned off from the surface, and a step of filtering the gas flow comprising the substances contained in the cleaned-off substances. A related system includes a supply device for supplying liquid CO2 and compressed air to at least one nozzle designed to generate solid particles by means of expanding the liquid CO2 to be directed onto a surface to be treated, a holding device for primary packaging, a substance removal device to remove substances cleaned from at least one surface by means of a gas flow; and a filter device for the gas flow comprising the cleaned substances.