Abstract: Provided is a method for determining, in a sample, enrichments of a first and a second stable-labeled tracer of a target substance including glucose, the first tracer and the second tracer having the same or similar chemical structure as the target substance, the method including: ionizing the first tracer, the second tracer and the target substance of the sample; measuring intensities of ions deriving from the target substance, the first tracer and the second tracer using a mass analyzer; calculating an enrichment of the first tracer from a first ratio of intensity of the ions deriving from the first tracer to the intensity of the ions deriving from the target substance employing a first calibration curve independent of enrichments of each of the second tracer; wherein the mass analyzer is operated so as to resolve an ion peak deriving from a tracer and having a width ?(m/z) at half maximum peak height equal to or smaller than 1×10?2.

Abstract: Provided is a method for determining, in a sample, enrichments of a first and a second stable-labeled tracer of a target substance including glucose, the first tracer and the second tracer having the same or similar chemical structure as the target substance, the method including: ionizing the first tracer, the second tracer and the target substance of the sample; measuring intensities of ions deriving from the target substance, the first tracer and the second tracer using a mass analyzer; calculating an enrichment of the first tracer from a first ratio of intensity of the ions deriving from the first tracer to the intensity of the ions deriving from the target substance employing a first calibration curve independent of enrichments of each of the second tracer; wherein the mass analyzer is operated so as to resolve an ion peak deriving from a tracer and having a width ?(m/z) at half maximum peak height equal to or smaller than 1×10?2.

Abstract: A placement aid for placing a catheter and a sensor wire into a body including a replacement device arranged in an interchangeable and replaceable manner having a main body, a placement needle, a catheter and a sensor wire. The placement needle is arranged within the catheter so that a tip of the placement needle protrudes from an end of the catheter along a puncturing direction and penetrates the skin when the catheter is inserted along the puncturing direction to generate a skin opening through which the catheter can be guided up to a subcutaneous final position. The sensor wire is arranged in the placement needle when the catheter is inserted along the puncturing direction and when the subcutaneous final position of the catheter is reached, the placement needle can be withdrawn from the catheter against the puncturing direction and the sensor wire remains in the catheter.

Abstract: A placement aid for placing a catheter and a sensor wire into a body including a replacement device arranged in an interchangeable and replaceable manner having a main body, a placement needle, a catheter and a sensor wire. The placement needle is arranged within the catheter so that a tip of the placement needle protrudes from an end of the catheter along a puncturing direction and penetrates the skin when the catheter is inserted along the puncturing direction to generate a skin opening through which the catheter can be guided up to a subcutaneous final position. The sensor wire is arranged in the placement needle when the catheter is inserted along the puncturing direction and when the subcutaneous final position of the catheter is reached, the placement needle can be withdrawn from the catheter against the puncturing direction and the sensor wire remains in the catheter.

Abstract: An arrangement for administering a predetermined amount of a substance into an organism is presented. The arrangement includes a member adapted to provide information indicative of a tissue resistance against flow of a fluid containing the substance upon administration into the tissue and a controller adapted to adjust an administration characteristic of the fluid based on the information such as to achieve an intended absorption rate of the substance.

Abstract: A medical apparatus for supplying a medication fluid into an organism and for detecting a substance of the organism is disclosed. The medical apparatus has a casing, cannula, and an insertion needle. The casing has a chamber accommodating the medication fluid and an opening in fluid communication with the chamber. The cannula has a lumen in fluid communication with the chamber. The insertion needle has a receptacle. A portion of the insertion needle is removably arrangeable within the lumen. The receptacle is configured to at least partially receive a sensor system for detecting the substance of the organism. A seal is adapted to annularly sealingly surround a portion of the sensor system when the insertion needle is removed from the opening and the portion of the sensor system is arranged in the opening.

Abstract: A medical apparatus for supplying a medication fluid into an organism and for detecting a substance of the organism is disclosed. The medical apparatus has a casing, cannula, and an insertion needle. The casing has a chamber accommodating the medication fluid and an opening in fluid communication with the chamber. The cannula has a lumen in fluid communication with the chamber. The insertion needle has a receptacle. A portion of the insertion needle is removably arrangeable with the lumen. The receptacle is configured to at least partially receive a sensor system for detecting the substance of the organism. A seal is adapted to annularly sealingly surround a portion of the sensor system when the insertion needle is removed from the opening and the portion of the sensor system is arranged in the opening.

Abstract: An arrangement for administering a predetermined amount of a substance into an organism is presented. The arrangement includes a member adapted to provide information indicative of a tissue resistance against flow of a fluid containing the substance upon administration into the tissue and a controller adapted to adjust an administration characteristic of the fluid based on the information such as to achieve an intended absorption rate of the substance.

Abstract: A device for delivery of glucose-regulating medication, particularly insulin, depending on the measured tissue glucose concentration, having a sensor for measuring the glucose concentration in tissue fluid, possibly a unit for removing fluid from subcutaneous tissue, as well as a container for the glucose-regulating medications, having a unit for subcutaneous delivery of the glucose-regulating medications, and having a unit connected to the glucose sensor for regulating the quantity of the glucose-regulating medication to be delivered depending on the measured tissue glucose concentrations. The device simulates the function of the natural pancreas and is constructed small and compact.

Abstract: A device for determining a value of a physiological parameter of a body fluid of a body under investigation, the device comprising a fluid reservoir for containing a perfusate fluid, a body interface insertable into the body under investigation for a fluid communication between the fluid reservoir and the body fluid, a fluid conduit between the fluid reservoir and the body interface, a bidirectional fluid transport unit for transporting the perfusate fluid from the fluid reservoir through the fluid conduit a the body interface into the body under investigation and for subsequently transporting a mixture of the perfusate fluid and the body fluid from the body under investigation through the body interface into the fluid conduit, and a sensor for sensing the value of the physiological parameter based on an analysis of the mixture of the perfusate fluid and the body fluid.

Abstract: A device (10) for delivery of glucose-regulating medication depending on the measured tissue glucose concentration, having a sensor (7) for measuring the glucose concentration in the tissue fluid, possibly a unit (1) for removing fluid from subcutaneous tissue (11), as well as a container (14) for the medications, having a unit (23) for subcutaneous delivery of the glucose-regulating medications, and having a unit (12) connected to the glucose sensor (7) for regulating the delivery of the glucose-regulating medication depending on the measured tissue glucose concentrations. To provide a device (10) simulating the function of the natural pancreas and being compact, the sensor (7) for measuring the tissue glucose concentration or the unit (1) for removing the tissue fluid is combined with the delivery unit (23), particularly in a shared catheter (25), so that the measurement of the tissue glucose concentration is essentially performed at the location of the delivery of the glucose-regulating medication.

Abstract: The invention relates to a device (5) for delivery of substances (9) to and removal of bodily substances (22) from a tissue (2) or vessel (25) of a body using an element (6) to be positioned in the tissue (2) or vessel (25).