Abstract: A cutting tool comprises a coating on a substrate. The coating comprises a first layer element having an overall composition comprising the metal or metalloid elements aluminum, chromium, titanium, and silicon. The first layer element comprises at least 2 Nlay first layer element layers. Each of the first layer element layers comprises a nitride layer comprising the metal or metalloid elements aluminum, chromium, titanium and silicon. The Nlay first layer element layers comprise at least two different types of layers that at least differ in a silicon content. A first type of the layers has a highest silicon content CSi,H, (in at. %) and a second type of the layers has a lowest silicon content CSi,L (in at. %), both relative to a total of the metal and metalloid elements, and with a ratio of the lowest silicon content CSi,L to the highest silicon content CSi,H in the range of 0.25?CSi,L/CSi,H?0.9.

Abstract: A method of manufacturing compacts and an arrangement for manufacturing compacts, in which the disadvantages of the state of the art are overcome and an efficient method and at the same time a simple construction and a simple implementation are achieved. This involves a method for manufacturing compacts, wherein after feeding the feedstock, pre-pressing into a pre-agglomerate using at least one pre-pressing punch or at least one stuffing screw and subsequently main pressing of the pre-agglomerate into a compact in at least one pressing die using at least one main pressing punch and subsequently ejection of the compact from the at least one pressing die are performed, pre-pressing, main pressing and ejection being performed in a mutually parallel working direction. This also involves an arrangement for manufacturing compacts, wherein at least one pressing die is provided in die tool receptacle with a feed for feedstock.

Abstract: A method for determining properties of a pipeline includes feeding a sound wave signal at a predetermined feed point into the pipeline so that the sound wave signal propagates in an axial direction of the pipeline. The frequency spectrum of the transmitted sound wave signal has a frequency component or a spectral range with a maximum frequency that is smaller than the lower limit frequency for the first upper mode. Reflected portions of the transmitted sound wave signal are detected as received sound wave signal and are evaluated with regard to the transmitted sound wave signal to determine at least the distance of each reflection site from the feed point.

Abstract: The invention relates to a method for determining properties of a pipeline, in particular the position of a branch of a sewage pipeline, in which a transmitted sound wave signal (S, S?) is fed at a predetermined feed point into the pipeline (1) and propagates in an axial direction of the pipeline (1), wherein the frequency spectrum of the transmitted sound wave signal (S, S?) has a frequency component or a spectral range with a maximum frequency that is smaller than the lower limit frequency (fc) for the first upper mode, in which, within the pipeline (1), reflected portions (Sr1, Sr2, Sr3, S?r1, S?r2, S?r3) of the transmitted sound wave signal (S, S?) are detected as received sound wave signal (E, E?), and in which the pipeline (1) is examined by an evaluation of the received sound wave signal (E, E?) with regard to the transmitted sound wave signal (S, S?) as to the presence of reflection sites causing sound wave reflections (Sr1, Sr2, Sr3, S?r1, S?r2, S?r3) along the pipeline (1), wherein, by means of the

Abstract: An air purification device for reducing pollutants in the air comprises an ionizer, which is exposed to the air flow and impinged upon by an ionization power from a drive stage for ionizing the air that is supplied by the air flow, and a gas sensor for measuring pollutant concentrations. To provide an air purification device, which purifies the air according to requirements even if the pollutant concentrations change rapidly and/or have extreme values, the driver stage, ionizer and gas sensor cooperate with a controller in a closed loop control circuit, in such a way that the output signal of the gas sensor essentially corresponds to a predetermined target value.

Abstract: The present invention relates to monoclonal antibodies binding to the N-terminal procollagen (III) propeptide (PIIINP) molecule which is a proteolytic fragment emanating from the specific cleavage of procollagen (III) by N-proteinase after exocytosis and to an assay using these antibodies.

Abstract: A process is disclosed for sterilising ambient air conducted in an air duct (401), as well as a use of a device for breaking down gaseous hydrocarbon emissions in order to sterilise ambient air conducted in an air duct (104), and a device for sterilising ambient air conducted in an air duct (401). Ambient air is supplied to the air duct (401) of an UV unit (403) for irradiation with UV radiation, and the thus pre-purified ambient air is supplied to a downstream ionization unit (407) arranged in the air duct and in which the ambient air is ionised.

Abstract: The invention relates to a device for purifying used air containing harmful substances, comprising a reaction stage according to the photooxidation principle. The reaction stage encompasses at least one air conduit inside which a tubular UV emitter is disposed along the direction of flow of the used air. In order to increase the decomposition rate within the used air conduit in a simple manner, the cross section of the at least one air conduit is embodied as a regular polygon having at least five sides.

Abstract: A lift truck is described, which comprises a frame (8), wheels fixed thereon close to (5) and remote from the load, a lifting mechanism, a load carrier (3), which is fixed to the lifting mechanism so as to be movable and can be moved up and down by means of a free-lift cylinder (44) via a free-lift chain (47) or a band-like transmission element, possibly a staged cylinder comprising a plurality of cylinders moving telescopically one inside the other for extending and retracting any sections of the lifting mechanism present, possibly a cabin roof. The lifting mechanism has only one mast, which comprises a first section (42) or a first section and further sections (40, 41) arranged within the first section. Therein, the first section is fixed on the frame and the first and further sections are in each case made of a non-circular hollow profile (60, 61, 62), which is closed in its azimuthal direction.

Abstract: The invention relates to an air purification device for reducing pollutants in the air. Said device comprises an ioniser, which is exposed to an air flow and impinged upon by an ionization power from a drive stage for ionising the air that is supplied by the air flow, and a gas sensor for measuring pollutant concentrations. To provide an air purification device, which purifies the air according to requirements even if the pollutant concentrations change rapidly and/or have extreme values, the driver stage, ionizer and gas sensor co-operate with a controller in a closed loop control circuit, in such a way that the output signal of the gas sensor essentially corresponds to a predetermined target value.

Abstract: The invention relates to novel 3-oxo-2,1-benzisomazol-1(3H)-carboxamides (I), where R1, R2 are the same or different and independently=H, halogen, C1 C6 alkyl C1 C6 alkoxy, C1 C3 perfluoroalkyl, or a group NR5R6; R3, R4 are the same or different and independently=C1 C8 alkyl, whose carbon chain is optionally interrupted by an O, S or NR7 and is optionally singly or severally substituted by C3 C6 cycloalkyl, C1 C4 alkoxy, OH, halogen or NR8R9; C3 C8 cycloalkyl whose carbon chain is optionally interrupted by an O, S or NR10 and is optionally singly or severally substituted by C1 C4 alkoxy, OH, halogen or NR11R12, or R3 and R4 together with a nitrogen atom form a saturated or partially unsaturated 3- to 10-membered mono- or bi-cyclic heteocycle, which, optionally, contains up to two further heteroatoms, from N, O or S and is, optionally, substituted by C1 C4 alkyl, C1 C4 alkoxy, OH, halogen, COOR13 or NR14R15 and X=O or S.

Abstract: The present invention relates to aprotinin variants having improved enzyme-inhibitory, immunological and pharmacokinetic properties and their preparation.

Abstract: The present invention relates to aprotinin variants having improved enzyme-inhibitory, immunological and pharmacokinetic properties and their preparation.

Abstract: The present invention relates to aprotinin variants having improved enzyme-inhibitory, immunological and pharmacokinetic properties and their preparation.

Abstract: The present invention relates to novel 2-aminocarbonyl-5(2H)-isoxazolones as selective ligands of a high-affinity binding site of diisopropyl fluorophosphate (DFP) on brain membranes for the prophylaxis and treatment of disorders of the central nervous system, in particular cognitive disorders, depression, schizophrenia and anxiety.

Abstract: The invention relates to acarviosyl transferase from actinomycetes, mainly from Actinoplanes sp. SE 50/110 and its mutants, to a process for isolating, purifying and characterizing the enzyme, to the isolation and characterization of the acbD gene encoding the acarviosyl transferase, to the expression of the acarviosyl transferase in a heterologous host organism, to the use of the acarviosyl transferase for converting acarbose minor constituents into acarbose or for preparing acarbose homologues, to the use of the acarviosyl transferase in acarbose purification, and also to the preparation of production mutants in which formation of minor constituents is reduced by means of inactivation of the acarviosyl transferase gene.

Abstract: Peptides having essentially the sequence of bovine pancreatic trypsin inhibitor (aprotinin) wherein one or more of the amino acids at positions 15, 16, 17, 18, 34, 39 and 52 are replaced by any naturally occurring amino acid produced by recombinant DNA technology, process, expression vector and recominant host therefor and pharmaceutical use thereof. Such peptides being useful as therapeutic agents in diseases connected with the presence of excessive amounts of proteinases.

Abstract: A method and device for reading out a fiber gyroscope based on the concept of determining, by gating the light signal for particular time intervals, only one particular phase section of the read-out signal of a photodetector of the fiber optic gyroscope modulated with a periodic function. Further phase sections are determined in sequence and cyclically in the same manner so that the entire photodetector signal is detected after one full cycle. Signals associated with individual phase sections are averaged separately and processed to obtain a rotation rate-proportional signal. The read-out signals can also be processed so that a control signal for deviation of the phase modulator is obtained and/or the gyroscope scale factor is stabilized.

Abstract: Peptides having essentially the sequence of bovine pancreatic trypsin inhibitor (aprotinin) wherein one or more of the amino acids at positions 15, 16, 17, 18, 34, 39 and 52 are replaced by any naturally occurring amino acid produced by recombinant DNA technology, process, expression vector and recominant host therefor and pharmaceutical use thereof. Such peptides being useful as therapeutic agents in diseases connected with the presence of excessive amounts of proteinases.