Patents by Inventor Werner Sieghart

Werner Sieghart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS AND THEIR METHODS OF USE
    Publication number: 20210047322
    Abstract: Provided herein are novel pyrazoloquinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis; depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.
    Type: Application
    Filed: October 23, 2020
    Publication date: February 18, 2021
    Inventors: Lih-Chu Chiou, James Cook, Margot Ernst, Pi-Chuan Fan, Daniel Knutson, Matheus Meirelles, Marko Mihovilovic, Werner Sieghart, Zdravko Varagic, Ranjit Verma, Laurin Wimmer, Christopher Witzigmann, David Chan Bodin Siebert, Miroslav M. Savic
  • LIGANDS SELECTIVE TO ALPHA 6 SUBUNIT-CONTAINING GABAA RECEPTORS AND THEIR METHODS OF USE
    Publication number: 20180134698
    Abstract: Provided herein are novel pyrazolo-quinolinone compounds and method of using such compounds to treat disorders such as neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia, tic disorders, attention deficit hyperactivity disorder, obsessive compulsive disorder, panic disorder, Huntington's disease and nocturnal enuresis;depression; temporomandibular myofascial pain; disorders of trigeminal nerve, such as trigeminal neuralgia and trigeminal neuropathy; migraine; and tinnitus.
    Type: Application
    Filed: June 3, 2016
    Publication date: May 17, 2018
    Inventors: Lih-Chu Chiou, James Cook, Margot Ernst, Pi-Chuan Fan, Daniel Knutson, Matheus Meirelles, Marko Mihovilovic, Werner Sieghart, Zdravko Varagic, Ranjit Verma, Laurin Wimmer, Christopher Witzigmann, David Chan Bodin Siebert, Miroslav M. Savic
  • N substituted 3-amino-2,2-di-c-alkyl-1,4-butyrolactones and 1,4-thiobutyrolactones for use as promoter of &ggr;-aminobutyric acid activity and for treating nervous disorders and preparation method
    Patent number: 6660769
    Abstract: The invention concerns compounds represented by general formula (I) wherein: Z represents a sulfur or oxygen atom; the groups R1 and R2, identical or different, represent each a alkyl group or an alkenyl group; X represents a CO, a CO2, an SO, or an SO2 and the group R represents an alkyl, aryl, alkenyl, or aralkyl group, provided that when Z represents an oxygen atom, X an SO2 and R a group (a), R1 and R2 do not both represent the methyl group. The invention also concerns methods for preparing said compounds, pharmaceutical compositions containing them and their use as promoter of &ggr;-aminobutyric acid and as medicine particularly designed for treating nervous disorders.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: December 9, 2003
    Assignees: Centre National de la Recherche Scientifique (CNRS), Innovationsagentur GmbH, Universite de Bern
    Inventors: Robert Dodd, Ahmed El Hadri, Jean-Paul Pierre Potier, Werner Sieghart, Frantisek Jursky, Roman Furtmuller, Erwin Sigel, Urs Thomet
  • N-substituted 1-(lactone) isoquinolones for treating nervous disorders
    Patent number: 6649626
    Abstract: The invention concerns compounds of general formula (I) wherein: Z represents a sulphur or oxygen atom, NH, N-alkyl or Nboc; group R′, identical or different, represent each a hydrogen atom, a OCH3 group or a OCH2O group; group R″ represents a hydrogen or a CH3 group; group X represents a carbonyl, sulphonyl or CO2 group; and group R represents an alkyl, aryl, alkenyl or aralkyl group. The invention also concerns the preparation of said compounds, pharmaceutical compositions containing them and their use for stimulating &ggr;-amino-butyric acid activity and as medicine for treating nervous disorders.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: November 18, 2003
    Assignees: Centre National de la Recherche Scientifique (CNRS), Universite de Bern, Innovationsagentur GmbH
    Inventors: Robert Dodd, Rodolphe Razet, Pierre Jean-Paul Potier, Werner Sieghart, Frantisek Jursky, Roman Furtmuller, Erwin Sigel, Urs Thomet