Patents by Inventor Werner Simon

Werner Simon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20080152730
    Abstract: Novel purified extracts from Ligusticum species are obtained by submitting crude extracts from Ligusticum species, particularly from Ligusticum wallichii (chuanxiong) containing less than 50 wt.-% of ligustilide to rectification under specific conditions.
    Type: Application
    Filed: January 26, 2006
    Publication date: June 26, 2008
    Inventors: Ralf Proplesch, Christoph Riegger, Werner Simon, Swen Wolfram
  • Publication number: 20080008798
    Abstract: Salts of Astaxanthin derivatives of the general formula I for use as fish feed additive, wherein R is in each case a group —NH—CH(R1)—COOR2, —OR3 or —(Y)n-Z and R1, R2, R3, Y, Z and n are significances given in detail in the description, are novel compounds with improved stability during extrusion at the elevated temperatures as required in feed manufacture and during the storage of the manufactured feed and which accordingly are useful as pigmenting carotinoids for feed for aquatic animals. The derivatives are produced by reacting astaxanthin with the pertinent acid RCOOH as such or as its acid chloride RCOCl or acid anhydride (RCO)2O, or, in the cases where R signifies a group —NH—CH(R1)—COOR2, with the appropriate N-carbonyl-amino acid ester of the formula OCNCH(R1)COOR2.
    Type: Application
    Filed: January 10, 2007
    Publication date: January 10, 2008
    Inventors: Arnold Gloor, Werner Simon
  • Patent number: 7253297
    Abstract: Astaxanthin derivatives of the general formula (I) wherein R is in each case group —NH—CH(R1)—COOR2, —OR3 or —(Y)n-Z and R1, R2, R3, Y, Z and n are significances given in detail in the description, are novel compounds with improved stability during extrusion at the elevated temperatures as required in feed manufacture and during the storage of the manufactured feed and which accordingly are useful as pigmenting carotinoids for feed for aquatic animals. The derivatives are produced by reacting astaxanthin with the pertinent acid RCOOH as such or as its acid chloride RCOC1 or acid anhydride (RCO)2O, or, in the cases where R signifies a group —NH—CH(R1)—COOR2, with the appropriate N-carbonyl-amino acid ester of the formula OCNCH(R1)COOR2.
    Type: Grant
    Filed: January 29, 2003
    Date of Patent: August 7, 2007
    Assignee: DSM IP Assetts B.V.
    Inventors: Arnold Gloor, Werner Simon
  • Patent number: 7244741
    Abstract: The invention relates to novel fredericamycin derivatives of general formula (Ia) or (Ib), to medicaments containing the fredericamycin derivatives or salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially tumor diseases.
    Type: Grant
    Filed: July 9, 2003
    Date of Patent: July 17, 2007
    Assignee: Biofrontera Discovery GmbH
    Inventors: Werner Simon, Ulrich Abel
  • Publication number: 20070110881
    Abstract: Astaxanthin derivatives of the general formula I wherein R is in each case a group —NH—CH(R1)—COOR2, —OR3 or —(Y)n—Z and R1, R2, R3, Y, Z and n are significances given in detail in the description, are novel compounds with improved stability during extrusion at the elevated temperatures as required in feed manufacture and during the storage of the manufactured feed and which accordingly are useful as pigmenting carotinoids for feed for aquatic animals. The derivatives are produced by reacting astaxanthin with the pertinent acid RCOOH as such or as its acid chloride RCOCl or acid anhydride (RCO)2O, or, in the cases where R signifies a group —NH—CH(R1)—COOR2, with the appropriate N-carbonyl-amino acid ester of the formula OCNCH(R1)COOR2. In particular, astaxanthin disuccinate and astaxanthin dimethyldisuccinate are disclosed.
    Type: Application
    Filed: January 10, 2007
    Publication date: May 17, 2007
    Inventors: Arnold Gloor, Werner Simon
  • Publication number: 20060111309
    Abstract: The invention relates to novel chalcomycin derivatives, medicaments containing said derivatives or the salts thereof, and the use of chalcomycin derivatives for treating diseases, especially infections. The inventive chalcomycin derivatives are acylated on the sugar esters and derivatives are also acylated on the 9-carbonyl function.
    Type: Application
    Filed: April 15, 2005
    Publication date: May 25, 2006
    Applicant: Biofrontera Discovery GmbH
    Inventors: Werner Simon, Rajendra Maskey, Hartmut Laatsch, Elisabeth Helmke, Friedrich Hansske
  • Publication number: 20050256066
    Abstract: The invention relates to novel fredericamycin derivatives, to drugs containing said derivatives or the salts thereof, and to the use of the fredericamycin derivatives for treating diseases, especially cancer diseases.
    Type: Application
    Filed: March 20, 2003
    Publication date: November 17, 2005
    Applicant: Biofrontera Discovery GmbH
    Inventors: Ulrich Abel, Werner Simon
  • Publication number: 20050215579
    Abstract: The invention relates to novel fredericamycin derivatives of general formula (Ia) or (Ib), to medicaments containing said derivatives or the salts of the same, and to the use of said fredericamycin derivatives for treating diseases, especially tumour diseases.
    Type: Application
    Filed: July 9, 2003
    Publication date: September 29, 2005
    Applicant: Biofrontera Discovery GmbH
    Inventors: Werner Simon, Ulrich Abel
  • Publication number: 20050153997
    Abstract: The invention relates to novel Fredericamycin derivatives, to medicaments containing these derivatives or salts thereof, and to the use of Fredericamycin derivatives for treating diseases, particularly tumor diseases.
    Type: Application
    Filed: March 28, 2003
    Publication date: July 14, 2005
    Applicant: Biofrontera Discovery Gmbh
    Inventors: Werner Simon, Ulrich Abel
  • Patent number: 6896895
    Abstract: The present invention is a method for pigmenting a food or foodstuff comprising combining in a source of feed, a carotenoid ester of formula I: wherein R is methyl, C3-16-alkyl, C3-16-alkenyl, or C5-8-cycloalkyl. Further embraced by the invention are the carotenoid-enriched feeds, e.g., for poultry, fish, or crustacea, premixes for incorporation in such feeds, and beadlets containing the carotenoid ester for incorporation in such premixes. A further aspect of the present invention is carotenoid esters of formula I.
    Type: Grant
    Filed: September 10, 2001
    Date of Patent: May 24, 2005
    Assignee: DSM IP Assets B.V.
    Inventors: Joseph Schierle, Werner Simon, Wolfgang Steinberg
  • Publication number: 20050096477
    Abstract: Astaxanthin derivatives of the general formula (I) wherein R is in each case group —NH—CH(R1)—COOR2, —OR3 or —(Y)n-Z and R1, R2, R3, Y, Z and n are significances given in detail in the description, are novel compounds with improved stability during extrusion at the elevated temperatures as required in feed manufacture and during the storage of the manufactured feed and which accordingly are useful as pigmenting carotinoids for feed for aquatic animals. The derivatives are produced by reacting astaxanthin with the pertinent acid RCOOH as such or as its acid chloride RCOCl or acid anhydride (RCO)2O, or, in the cases where R signifies a group —NH—CH(R1)—COOR2, with the appropriate N-carbonyl-amino acid ester of the formula OCNCH(R1)COOR2.
    Type: Application
    Filed: January 29, 2003
    Publication date: May 5, 2005
    Inventors: Arnold Gloor, Werner Simon
  • Patent number: 6465698
    Abstract: A process for catalytically isomerizing Z-3-methylpent-2-en-4-yn-1-ol to E-3-methylpent-2-en-4-yn-1-ol is provided. This process includes contacting a stereoisomeric mixture containing Z-3-methylpent-2-en-4-yn-1-ol and E-3-methylpent-2-en-4-yn-1-ol with a source of bromine radicals in a two-phase reaction mixture having an aqueous phase and a stereoisomeric mixture phase, intermixing the reaction mixture, and heating the reaction mixture to a temperature from about −10° C. to about 100° C.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: October 15, 2002
    Assignee: Roche Vitamins, Inc.
    Inventors: Arnold Gloor, Hansjoerg Gruendler, Werner Simon
  • Publication number: 20020114867
    Abstract: The present invention is a method for pigmenting a food or foodstuff comprising combining in a source of feed, a carotenoid ester of formula I: 1
    Type: Application
    Filed: September 10, 2001
    Publication date: August 22, 2002
    Inventors: Joseph Schierle, Werner Simon, Wolfgang Steinberg
  • Patent number: 6418871
    Abstract: The invention relates to a connector (15) which consists of an anchor connection component (16) and a chain connection component (17). Said anchor connection component (16) is provided at its one end with a location fork (21) for the anchor. Said chain connection component (17) is provided at its one end with a fork part (41) for accommodating a chain link. One screw bolt (25, 46) each penetrates the limbs (23, 24) of the location fork and the limbs (44, 45) of the fork part (41). Said screw bolt is fixed with its head in the one limb and with its screw shaft (28, 47) in the other limb and is secured by an attachment screw (48) if required. The anchor connection component (16) and the chain connection component (17) are linked with one another via a ball-and-socket joint (19). One component is provided with a ball (38) and the other component with a socket (34) with an opening (37) leading to the location fork (21).
    Type: Grant
    Filed: December 18, 2000
    Date of Patent: July 16, 2002
    Inventor: Werner Simon
  • Publication number: 20020042547
    Abstract: A process for catalytically isomerizing Z-3-methylpent-2-en-4-yn-1-ol to E-3-methylpent-2-en-4-yn-1-ol is provided. This process includes contacting a stereoisomeric mixture containing Z-3-methylpent-2-en-4-yn-1-ol and E-3-methylpent-2-en-4-yn-1-ol with a source of bromine radicals in a two-phase reaction mixture having an aqueous phase and a stereoisomeric mixture phase, intermixing the reaction mixture, and heating the reaction mixture to a temperature from about −10° C. to about 100° C.
    Type: Application
    Filed: June 11, 2001
    Publication date: April 11, 2002
    Applicant: Roche Vitamins Inc.
    Inventors: Arnold Gloor, Hansjoerg Gruendler, Werner Simon
  • Patent number: 6242498
    Abstract: Substituted benzophenone compounds and a process for manufacturing them, are disclosed. The compounds have the formula: The compounds are useful as fungicides having high systemicities.
    Type: Grant
    Filed: August 5, 1998
    Date of Patent: June 5, 2001
    Inventors: Juergen Curtze, Werner Simon, Andreas Waldeck, Henry Van Tuyl Cotter, Annerose Rehnig
  • Patent number: 6225484
    Abstract: The invention relates to an improved process for the preparation of a compound of formula I wherein R1 represents an optionally substituted aryl group, R2 represents an optionally substituted alkyl group, and R3 and R4 each individually represent an alkyl group; which comprises heating a mixture of a compound of formula II an alcohol, a tri-alkoxymethane, an acid and, optionally, an inert diluent.
    Type: Grant
    Filed: August 12, 1999
    Date of Patent: May 1, 2001
    Assignee: American Cyanamid Co.
    Inventors: Werner Simon, Thomas Petry
  • Patent number: 6062791
    Abstract: The screw unit for the adjustable and lockable spanning of distances between structural components, brackets, and for adjusting assemblies, etc., consists of a threaded pin, which has adjusting surfaces and a central bore passing through it, and a nut, which is screwed onto the threaded pin. This nut is designed as a support sleeve with an internal thread and adjusting surfaces, into which the threaded pin can be screwed until it is more or less flush. On the end facing an adjusting collar, the support sleeve is provided with an inward-projecting, ring-shaped collar with the internal thread, whereas the free end of the threaded pin is provided with a stop element to prevent the pin from being completely unscrewed.
    Type: Grant
    Filed: February 9, 1999
    Date of Patent: May 16, 2000
    Inventor: Werner Simon
  • Patent number: 5945567
    Abstract: Substituted benzophenone compounds are disclosed, having the formula: ##STR1## The compounds are useful as fungicides having high systemicities.
    Type: Grant
    Filed: August 20, 1997
    Date of Patent: August 31, 1999
    Assignee: American Cyanamid Company
    Inventors: Juergen Curtze, Werner Simon, Gerd Morschhaeuser, Andreas Waldeck, Karl-Otto Stumm, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Gunther Reichert
  • Patent number: 5922905
    Abstract: Substituted benzoic acid compounds are disclosed, having the formula: ##STR1## The compounds find use as intermediates for the production of agricultural fungicides.
    Type: Grant
    Filed: October 17, 1997
    Date of Patent: July 13, 1999
    Assignee: American Cyanamid Company
    Inventors: Juergen Curtze, Werner Simon, Gerd Morschhaeuser, Andreas Waldeck, Karl-Otto Stumm, Henry Van Tuyl Cotter, Guido Albert, Annerose Rehnig, Gunther Reichert