Abstract: The present invention refers to an optimized 3-phytase which is a bio-efficacious phytase mutant having sequence identity of at least 95% around 3-phytase (SEQ ID NO. 1) comprising a sequence of SEQ ID NO. 2 and one or more mutations. The invention is further directed to the use of such optimized 3-phytase in the production of a food or feed product.

Abstract: The present invention relates to a method for detecting an analyte in a sample comprising the steps of providing detection probes being labeled with a first reporter, which detection probes are capable of binding to the analyte, providing a solid support, providing capture probes being bound or capable of binding to the solid support, which capture probes are capable of binding to the analyte, thus concentrating the analyte on the solid support, contacting the sample with the detection probes, the solid support and the capture probes, and detecting the detection probes, wherein the detection of detection probes is conducted in the presence of quenching probes binding to surplus detection probes not being bound to the analyte and thereby quenching at least partially an emission of the first reporter of said surplus detection probes and/or the solid support is labeled with a second reporter different from the first reporter, imaging the sample at an emission wavelength of the second reporter, generating a m

Abstract: The present invention relates to an improved microplate which is constructed of at least one frame part and at least one bottom part, where the bottom part has a maximum thickness of 500 ?m.

Abstract: The present invention relates to a method for detecting an analyte in a sample comprising the steps of providing detection probes being labeled with a first reporter, which detection probes are capable of binding to the analyte, providing a solid support, providing capture probes being bound or capable of binding to the solid support, which capture probes are capable of binding to the analyte, thus concentrating the analyte on the solid support, contacting the sample with the detection probes, the solid support and the capture probes, and detecting the detection probes, wherein the detection of detection probes is conducted in the presence of quenching probes binding to surplus detection probes not being bound to the analyte and thereby quenching at least partially an emission of the first reporter of said surplus detection probes and/or the solid support is labeled with a second reporter different from the first reporter, imaging the sample at an emission wavelength of the second reporter, generating a m

Abstract: The present invention relates to a method for detecting analytes in a sample comprising the steps of providing a solid support, providing capture probes being bound or capable of binding to the solid support, which capture probes are also capable of binding to the analytes, thus concentrating the analytes on the solid support, providing detection probes which are capable of binding to the analytes, contacting the sample with the detection probes, the solid support and the capture probes, and detecting through use of confocal observation the analytes which are bound to the detection probes.

Abstract: The present invention relates to a method for detecting analytes in a sample comprising the steps of providing a solid support, providing capture probes being bound or capable of binding to the solid support, which capture probes are also capable of binding to the analytes, thus concentrating the analytes on the solid support, providing detection probes which are capable of binding to the analytes, contacting the sample with the detection probes, the solid support and the capture probes, and detecting through use of confocal observation the analytes which are bound to the detection probes.

Abstract: The present invention relates to 6-carboxyphenyldihydropyridazinone derivatives having the formula wherein R1, R2, R3, A, D, G, and E are as defined in the specification and claims, a process for preparing these materials, pharmaceutical compositions containing them, and a method for using them in the treatment of anemias.

Abstract: The invention relates to the area of erythropoiesis, in particular to the use of tetrahydroquinolinyl-6-methyldihydrothiadiazinones of general formula (I) for treating anaemia. The invention also relates to novel tetrahydroquinolinyl-6-methyldihydrothiadiazinone derivatives and to the production thereof.