Patents by Inventor Werner Stuber
Werner Stuber has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7201260Abstract: A subassembly for the amplitude-dependent absorption of shock, especially in a dashpot for a motor vehicle with a piston and an oscillating piston rod. The piston (3) is accommodated in a housing (2), partitioning the housing into two compartments (4 & 5), and travels up and down inside the housing, radially aligned and axially subject to motion-limiting tension, on the end of the piston rod (1). The object is a simple and reliable subassembly that takes up little additional space. The piston is accordingly axially tensioned between two springs (17 & 18).Type: GrantFiled: May 26, 2004Date of Patent: April 10, 2007Assignee: ThyssenKrupp Bilstein GmbHInventors: Manfred Diederich, Jan Kirch, Werner Stüber
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Patent number: 6932968Abstract: Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibodies are suitable for purifying EPO, EPO derivatives or EPO peptides. The epitope-specific anti-EPO antibodies according to the invention can also be used for the detection of EPO and, in particular, for the epitope-specific detection of EPO. Additionally described are anti-idiotype antibodies which imitate a receptor region of EPO. Finally, pharmaceuticals which contain the EPO peptides, anti-EPO antibodies or anti-idiotype antibodies, and diagnostic aids for the detection of EPO or of anti-EPO antibodies, are described.Type: GrantFiled: July 21, 1997Date of Patent: August 23, 2005Assignee: Dade Behring Marburg GmbHInventors: Mathias Fibi, Werner Stüber
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Publication number: 20040245058Abstract: A subassembly for the amplitude-dependent absorption of shock, especially in a dashpot for a motor vehicle with a piston and an oscillating piston rod. The piston (3) is accommodated in a housing (2), partitioning the housing into two compartments (4 & 5), and travels up and down inside the housing, radially aligned and axially subject to motion-limiting tension, on the end of the piston rod (1). The object is a simple and reliable subassembly that takes up little additional space. The piston is accordingly axially tensioned between two springs (17 & 18).Type: ApplicationFiled: May 26, 2004Publication date: December 9, 2004Inventors: Manfred Diederich, Jan Kirch, Werner Stuber
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Publication number: 20040053372Abstract: The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof for the immunization of an animal and for the purification of specific antibodies, to antibodies against these peptides, and to the use of the antibodies for the determination of the fragments F2/F1+2. The antibodies hitherto used for the determination of the content of the fragments F2/F1+2 have been induced by immunization with natural, highly purified prothrombin fragments F2/F1+2. The isolation of these prothrombin fragments is elaborate and costly, and the antibodies generated therewith show cross-reactions with intact prothrombin. Used for the immunization according to the invention are synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic.Type: ApplicationFiled: January 31, 2003Publication date: March 18, 2004Inventors: Hermann Pelzer, Werner Stuber
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Patent number: 6566085Abstract: The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof for the immunization of an animal and for the purification of specific antibodies, to antibodies against these peptides, and to the use of the antibodies for the determination of the fragments F2/F1+2.Type: GrantFiled: November 20, 1991Date of Patent: May 20, 2003Assignee: Dade Behring Marburg GmbHInventors: Hermann Pelzer, Werner Stüber
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Patent number: 6538113Abstract: The invention relates to synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic, to the use thereof for the immunization of an animal and for the purification of specific antibodies, to antibodies against these peptides, and to the use of the antibodies for the determination of the fragments F2/F1+2. The antibodies hitherto used for the determination of the content of the fragments F2/F1+2 have been induced by immunization with natural, highly purified prothrombin fragments F2/F1+2. The isolation of these prothrombin fragments is elaborate and costly, and the antibodies generated therewith show cross-reactions with intact prothrombin. Used for the immunization according to the invention are synthetic peptides which have amino acid sequences which correspond, in whole or in part, to the amino acid sequence of prothrombin and are antigenic.Type: GrantFiled: June 7, 1995Date of Patent: March 25, 2003Assignee: Dade Behring Marburg GmbHInventors: Hermann Pelzer, Werner Stüber
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Patent number: 6441141Abstract: The present invention is directed to the generation of antibodies which preferentially bind to fibrinogen fragments E1, E2 and E3, but exhibit little or no cross-reactivity against fibrin monomer and fibrinogen. Thus, the invention provides synthetic peptides containing defined amino acid sequences corresponding to the carboxy terminal regions of the E fragments which arise as a result of plasmin cleavage of fibrin and fibrinogen. The synthetic peptides may be synthesized chemically, or through genetic manipulations, and may contain additional amino acid sequences which are not contiguous with the defined E fragment sequences.Type: GrantFiled: September 29, 1999Date of Patent: August 27, 2002Assignee: Dade Behring Marburg GmbHInventors: Michael Kraus, Werner Stüber
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Patent number: 6143493Abstract: The invention relates to peptides for the immunochemical determination of human cytomegalovirus (HCMV)-specific antibodies and HCMV antigens, and to agents suitable for this method and to the use thereof.Type: GrantFiled: June 5, 1995Date of Patent: November 7, 2000Assignee: Dade Behring Marburg GmbHInventors: Werner Stuber, Leszek Wieczorek, Robert Ziegelmaier
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Patent number: 5981697Abstract: The present invention is directed to the generation of antibodies which preferentially bind to fibrinogen fragments E1, E2, and E3, but exhibit little or no cross-reactivity against fibrin monomer and fibrinogen. Thus, the invention provides synthetic peptides containing defined amino acid sequences corresponding to the carboxy terminal regions of the E fragments which arise as a result of plasmin cleavage of fibrin and fibrinogen. The synthetic peptides may be synthesized chemically, or through genetic manipulations, and may contain additional amino acid sequences which are not contiguous with the defined E fragment sequences.Type: GrantFiled: October 8, 1996Date of Patent: November 9, 1999Assignee: Behringwerke AktiengesellschaftInventors: Michael Kraus, Werner Stuber
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Patent number: 5859185Abstract: The invention relates to peptides for the immunochemical determination of human cytomegalovirus (HCMV)-specific antibodies and HCMV antigens, and to agents suitable for this method and to the use thereof.Type: GrantFiled: February 13, 1995Date of Patent: January 12, 1999Assignee: Behringwerke AktiengesellschaftInventors: Werner Stuber, Leszek Wieczorek, Robert Ziegelmaier
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Patent number: 5744298Abstract: The invention relates to a DNA sequence which encodes three specific human cytomegalovirus (HCMV) peptides of the pp150 protein. These peptides are shown to have novel immunogenic properties. The DNA sequence is also used in a method of hybridization for the detection of fully complementary sequences.Type: GrantFiled: June 5, 1995Date of Patent: April 28, 1998Assignee: Behringwerke AktiengesellschaftInventors: Werner Stuber, Leszek Wieczorek, Robert Ziegelmaier
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Patent number: 5712370Abstract: Erythropoietin (EPO) peptides and the use thereof for preparing epitope-specific anti-EPO antibodies are described. Also described are corresponding anti-EPO antibodies which take the form of polyclonal antibodies (antisera) or of monoclonal antibodies. These antibodies are suitable for purifying EPO, EPO derivatives or EPO peptides. The epitope-specific anti-EPO antibodies according to the invention can also be used for the detection of EPO and, in particular, for the epitope-specific detection of EPO. Additionally described are anti-idiotype antibodies which imitate a receptor region of EPO. Finally, pharmaceuticals which contain the EPO peptides, anti-EPO antibodies or anti-idiotype antibodies, and diagnostic aids for the detection of EPO or of anti-EPO antibodies, are described.Type: GrantFiled: June 29, 1994Date of Patent: January 27, 1998Assignee: Behringwerke AktiengesellschaftInventors: Mathias Fibi, Werner Stuber
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Patent number: 5607858Abstract: Peptide amides of the formula I (SEQ ID NOS: 3-21)GPRP--X--NR.sub.1 --R.sub.2 Iwhere G is the amino acid glycine, P is the amino acid L-proline, R is the amino acid L-arginine, X is a proteinogenous amino acid apart from proline or a dipeptide from these amino acids including proline, N is nitrogen and R.sub.1 and R.sub.2 are identical or different and are hydrogen or a lower alkyl chain having up to 4 carbon atoms; processes for the preparation thereof and the use thereof as medicament or for diagnostic purposes are described.Type: GrantFiled: June 7, 1995Date of Patent: March 4, 1997Assignee: Behringwerke AktiengesellschaftInventors: Werner Stuber, Karl Fickenscher
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Patent number: 5599678Abstract: The invention relates to antibodies which react with fibrinogen fragments E1, E2 and E3 raised by immunizing with a peptide. The invention also relates to assay methods for proteins containing an epitope which is common to fibrinogen fragments E1, E2 and E3 using these antibodies.Type: GrantFiled: December 15, 1993Date of Patent: February 4, 1997Assignee: Behringwerke AktiengesellschaftInventors: Michael Kraus, Werner Stuber
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Patent number: 5556941Abstract: Glycopeptide derivatives, a process for their preparation and pharmaceutical agents containing these compounds N-Glycopeptide derivatives of the formula I ##STR1## where aromatic is an unsubstituted or substituted benzene residue, naphthalene residue, chroman residue, chromene residue or coumarone residue,a is 0 to 5, b is 0 to 4, c is 0 or 1, d is 1 or 2R.sup.1 is (C.sub.1 -C.sub.3)-alkyl,R.sup.2 is (C.sub.1 -C.sub.3)-alkyl or (C.sub.1 -C.sub.3)-alkyloxy,R.sup.3 is H, OH, (C.sub.1 -C.sub.3)-alkyloxy, NH.sub.2, NH-(C.sub.1 -C.sub.6)-alkanoyl, NH-benzoyl, NH--SO.sub.3 H or NH-acyl radical of a natural N-acetylated amino acid,R.sup.4 is H, OH, or (C.sub.1 -C.sub.3)-alkyloxy,R.sup.5 is H, OH, (C.sub.1 -C.sub.3)-alkyloxy, fluorine, chlorine or bromine,R.sup.6 is H, CH.sub.3, CH.sub.2 OH, CH.sub.2 O--(C.sub.1 -C.sub.6), CH.sub.2 NHCOCH.sub.3 or CH.sub.2 NH--SO.sub.3 H,R.sup.5 and R.sup.6 are together O--CH.sub.2 --O--CH.sub.2, --O--CH(CH.sub.3)--O--CH.sub.2 or O--C(CH.sub.3).sub.2 --O--CH.sub.2,R.sup.Type: GrantFiled: August 16, 1994Date of Patent: September 17, 1996Assignee: Behringwerke AktiengesellschaftInventors: Cenek Kolar, Werner Stuber
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Patent number: 5478810Abstract: Peptide amides of the formula I (SEQ ID NOS: 3-21)GPRP--X--NR.sub.1 --R.sub.2 Iwhere G is the amino acid glycine, P is the amino acid L-proline, R is the amino acid L-arginine, X is a proteinogenous amino acid apart from proline or a dipeptide from these amino acids including proline, N is nitrogen and R.sub.1 and R.sub.2 are identical or different and are hydrogen or a lower alkyl chain having up to 4 carbon atoms; processes for the preparation thereof and the use thereof as medicament or for diagnostic purposes are described.Type: GrantFiled: February 24, 1993Date of Patent: December 26, 1995Assignee: Behringwerke AktiengesellschaftInventors: Werner Stuber, Karl Fickenscher
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Patent number: 5457114Abstract: Amidinophenylalanine derivatives of the formula I ##STR1## the synthesis of these compounds, the use thereof and pharmaceutical agents which contain these compounds are described.Type: GrantFiled: January 25, 1994Date of Patent: October 10, 1995Assignee: Behringwerke AktiengesellschaftInventors: Werner Stuber, Gerhard Dickneite, Rainer Koschinsky, Cenek Kolar
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Patent number: 5334506Abstract: Compounds of the formula I ##STR1## in which X denotes a hydrogen atom, a group which irreversibly masks the terminal amino group, or a protecting group which is conventional in peptide chemistry, such as, for example, Boc-, Z- or Fmoc-,A and B may be identical or different and denote an alpha- beta- or gamma-amino acid which comprises 2 to 15 carbon atoms and up to 4 nitrogen atoms, 2 sulfur atoms and 6 oxygen atoms and whose side chain may be substituted, and B, if appropriate, denotes a dipeptide formed from these amino acids,C denotes arginine, Lysine, tyrosine, phenylalanine or tryptophane, and their homologs,R.sub.1 and R.sub.2 are identical or different and denote a hydrogen atom or an alkyl radical having up to 4 carbon atoms,R.sub.3 to R.sub.8 are identical or different and denote hydrogen, an alkyl radical, an alkoxy radical or a halogen radical,Y denotes oxygen, andAn.sup.- denotes an anion, and their water-soluble salts, and a process for their preparation are described.Type: GrantFiled: October 30, 1991Date of Patent: August 2, 1994Assignee: Behringwerke AktiengesellschaftInventors: Werner Stuber, Dieter Schnaitmann
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Patent number: 5254672Abstract: The invention relates to synthetic peptides which contain certain partial sequences from factor VIIa, the synthesis thereof and the use of these peptides for immunizing an animal and for purifying specific antibodies against the said peptides, to antibodies against these peptides and the use of these antibodies and peptides in therapy and diagnosis.Type: GrantFiled: March 11, 1991Date of Patent: October 19, 1993Assignee: Behringwerke AktiengesellschaftInventors: Hermann Pelzer, Werner Stuber
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Patent number: 5204240Abstract: A method for the detection and for the determination of blood coagulation factor XIII in plasma, as well as a kit containing means which can be used in this method, are described.Used in this method are a fibrin-aggregation inhibitor, thrombin, a glutamine-containing peptide as substrate for factor XIII, an amine and a system for detecting ammonia which is formed.The kit containing means which can be used in this method contains a fibrin-aggregation inhibitor and a glutamine-containing peptide, where appropriate in addition to other components necessary for the method.Type: GrantFiled: April 5, 1989Date of Patent: April 20, 1993Assignee: Behringwerke AktiengesellschaftInventor: Werner Stuber