Patents by Inventor Werner Traunecker
Werner Traunecker has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 5223614Abstract: Compounds of formula ##STR1## wherein the substituents are defined hereinbelow, useful in the treatment of bronchospasm are described.Type: GrantFiled: October 25, 1990Date of Patent: June 29, 1993Assignee: Boehringer Ingelheim GmbHInventors: Kurt Schromm, Anton Mentrup, Ernst-Otto Renth, Gojko Mualcevic, Werner Traunecker
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Patent number: 4609672Abstract: The invention relates to a compound of the formula ##STR1## wherein R.sub.1 is a linear or branched alkyl of 4 to 20 carbon atoms;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; andR.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other, are --(CH.sub.2).sub.p --, where p is an integer from 4 to 6, inclusive,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.Type: GrantFiled: June 25, 1984Date of Patent: September 2, 1986Assignee: C. H. Boehringer SohnInventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker
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Patent number: 4546102Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl of 1 to 4 carbon atoms or trifluoromethyl;R.sub.2, R.sub.3 and R.sub.4 are each independently hydrogen, methyl or ethyl;R.sub.5 is hydrogen, alkyl of 1 to 8 carbon atoms, phenyl-(alkyl of 1 to 8 carbon atoms), cycloalkyl of 3 to 7 carbon atoms, (alkoxy of 1 to 4 carbon atoms) carbonyl-methyl, phenyl, substituted phenyl, naphthyl or substituted naphthyl; orR.sub.4 and R.sub.5, together with each other, are alkylene of 4 to 5 carbon atoms, optionally interrupted by --O-- or --NR.sub.6 --, where R.sub.6 is alkyl of 1 to 4 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as cardiotonics.Type: GrantFiled: October 31, 1983Date of Patent: October 8, 1985Assignee: Boehringer Ingelheim KGInventors: Ernst-Otto Renth, Anton Mentrup, Kurt Schromm, Werner Traunecker, Richard Reichl
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Patent number: 4499106Abstract: Lipolytic pharmaceutical composition containing 1-(4-hydroxy-3-dimethylamino-sulfonamidophenyl)-1-hydroxy-2-(1-phenoxy-iso propylamino)ethane or a pharmaceutically acceptable acid addition salt thereof as the active ingredient, and a method of combatting obesity therewith.Type: GrantFiled: May 20, 1983Date of Patent: February 12, 1985Assignee: Boehringer Ingelheim KGInventors: Werner Traunecker, Wilhelm Frolke, Heinrich Kreuzer, Hans P. Kollmer
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Patent number: 4442120Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, lower alkinyloxy, lower cycloalkyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or the ring-forming group (--CH.dbd.CH).sub.2 or --(CH.sub.Type: GrantFiled: July 15, 1982Date of Patent: April 10, 1984Assignee: Boehringer Ingelheim KGInventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker
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Patent number: 4442121Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is cycloalkyl of 3 to 10 carbon atoms; phenyl; mono- or poly-substituted phenyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkenyloxy, lower alkinyl, nitro, trifluoromethyl, hydroxyl, acyl, acyloxy, lower alkoxycarbonyl, hydroxy-lower alkyl, lower alkoxy-lower alkyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the phenyl ring; aryloxy-lower alkyl; (mono- or poly-substituted aryl)-oxy-lower alkyl, where the substituents are halogen, lower alkyl, lower alkoxy, lower alkenyl, lower alkinyl, acyl, acyloxy, nitro, trifluoromethyl or the ring-forming groups (--CH.dbd.CH--).sub.2 or --O--CH.sub.2 --O-- attached to vicinal carbon atoms of the aryl ring;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or the ring-forming group (--CH.dbd.CH ).sub.2 or --(CH.sub.2).sub.Type: GrantFiled: July 15, 1982Date of Patent: April 10, 1984Assignee: Boehringer Ingelheim K.G.Inventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker
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Patent number: 4438143Abstract: This invention relates to compounds of the formula ##STR1## wherein R.sub.1 represents a linear or branched alkyl of from 1 to 20 carbon atoms;R.sub.2 represents a hydrogen or halogen atom, a linear or branched alkyl or alkoxy of from 1 to 4 carbon atoms, or a divalent group --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, in which n is an integer of from 3 to 5, with the free valences bonded in the o-position relative to one another; andR.sub.3 represents a linear or branched alkyl of from 3 to 10 carbon atoms, with the provisos that R.sub.3 is not tert.butyl when R.sub.1 is ethyl or propyl and R.sub.2 is a hydrogen atom and that R.sub.3 is not isopropyl when R.sub.1 is propyl and R.sub.2 is a hydrogen atom,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of Formula I are useful for treatment and prophylaxis of diseases of the coronaries, for the treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.Type: GrantFiled: September 21, 1982Date of Patent: March 20, 1984Assignee: Boehringer Ingelheim KGInventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker
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Patent number: 4363814Abstract: Racemic or optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl, orR.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy;n is an integer from 2 to 6, inclusive; andR is hydrogen, benzyl or ##STR2## and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as vasodilators and CNS-stimulators.Type: GrantFiled: December 22, 1980Date of Patent: December 14, 1982Assignee: Boehringer Ingelheim GmbHInventors: Anton Mentrup, Kurt Schromm, Ernst-Otto Renth, Richard Reichl, Werner Traunecker
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Patent number: 4344964Abstract: This invention relates to a compound of the formula ##STR1## wherein R.sub.1 is ethyl or isopropyl;R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or a bivalent radical --CH.dbd.CH--CH.dbd.CH-- or --(CH.sub.2).sub.n --, where n is an integer from 3 to 5, inclusive, and the free bonds of said bivalent radical are attached to adjacent carbon atoms of the phenyl ring; andR.sub.3 is hydrogen or alkyl of 1 to 3 carbon atoms;R.sub.4 is alkyl of 1 to 3 carbon atoms; orR.sub.3 and R.sub.4, together with each other, are --(CH.sub.2).sub.p --, where p is an integer from 4 to 6, inclusive,or a non-toxic, pharmacologically acceptable acid addition salt thereof. The compounds of formula I are useful for treatment and prophylaxis of diseases of the coronaries, for treatment of hypertension, and for treatment of cardiac arrhythmia, particularly tachycardia.Type: GrantFiled: March 9, 1981Date of Patent: August 17, 1982Assignee: C. H. Boehringer SohnInventors: Herbert Koppe, Werner Kummer, Helmut Stahle, Gojko Muacevic, Werner Traunecker
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Patent number: 4322418Abstract: This invention relates to substituted 1-(.alpha.-aminocarbonyl-benzyl)-3,4-dihydro-isoquinolines in the racemic or optically active form and the non-toxic pharmacologically acceptable salts thereof. These compounds are useful in the promotion of blood circulation in warm-blooded animals.Type: GrantFiled: April 3, 1981Date of Patent: March 30, 1982Assignee: C. H. Boehringer SohnInventors: Walter Losel, Franz Esser, Otto Roos, Richard Reichl, Franz J. Kuhn, Werner Traunecker
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Patent number: 4215119Abstract: Racemic and optically active compounds of the formulaQ-C.sub.n H.sub.2n -NH-Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl,R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, andA is --O--, --CH.sub.2 --CH.sub.2 --, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl or 1 to 4 carbon atoms,n is an integer from 2 to 6, inclusive, andR is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl,R.sub.5, R.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.8 O--, methylsulfonylmethyl or, when one or two of R.sub.5 through R.sub.Type: GrantFiled: April 3, 1979Date of Patent: July 29, 1980Assignee: Boehringer Ingelheim GmbHInventors: Anton Mentrup, Kurt Schromm, Ernst-Otto Renth, Richard Reichl, Werner Traunecker, Wolfgang Hoefke
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Patent number: 4154829Abstract: Racemic and optically active compounds of the formulaQ--C.sub.n H.sub.2n --NH--Rwherein Q is ##STR1## where R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, trifluoromethyl or amino,R.sub.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or trifluoromethyl,R.sub.1 and R.sub.2, together with each other, are methylenedioxy or ethylenedioxy, andA is --O--, --CH.sub.2 --CH.sub.2 --, --O--CH.sub.2 -- where the oxygen is bonded to the benzene ring, or --NR.sub.3 -- where R.sub.3 is hydrogen or alkyl of 1 to 4 carbon atoms,N is an integer from 2 to 6, inclusive, andR is hydrogen, benzyl or ##STR2## where R.sub.4 is hydrogen, methyl or ethyl,R.sub.5, r.sub.6 and R.sub.7, which may be identical to or different from each other, are each hydrogen, halogen, hydroxymethyl, trifluoromethyl, alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms, nitro, cyano, --CONHR.sub.3, --CONHOH, --COOR.sub.3, R.sub.Type: GrantFiled: March 2, 1977Date of Patent: May 15, 1979Assignee: Boehringer Ingelheim GmbHInventors: Anton Mentrup, Kurt Schromm, Ernst-Otto Renth, Richard Reichl, Werner Traunecker, Wolfgang Hoefke
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Patent number: 4146645Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, --(CH.sub.2).sub.n --R.sub.4 or --CO--R.sub.5,where n is 1 or 2,R.sub.4 is hydrogen, cyano or benzoyl, andR.sub.5 is hydrogen, lower alkoxy, benzyloxy, --CH.sub.2 --NH.sub.2, --CH(CH.sub.3)--NH.sub.2, --CH.sub.2 --NH--CH.sub.2 --C.sub.6 H.sub.5 or --CH(CH.sub.3)--NH--CH.sub.2 --C.sub.6 H.sub.5,R.sub.2 is hydrogen or methyl, andR.sub.3 is amino, nitro, --NH--CO--R.sub.6 or --NH--A--R.sub.7,where R.sub.6 is hydrogen, methyl, methoxy, ethoxy, methylthio or ethylthio,R.sub.7 is amino, methylamino or dimethylamino, andA is --CO-- or --SO.sub.2 --,provided, however, that R.sub.1 and R.sub.4 are other than hydrogen and R.sub.2 is other than hydrogen or methyl when R.sub.6 is hydrogen or methyl, and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as hypertensives.Type: GrantFiled: January 24, 1977Date of Patent: March 27, 1979Assignee: Boehringer Ingelheim GmbHInventors: Kurt Schromm, Anton Mentrup, Ernst-Otto Renth, Ludwig Pichler, Werner Traunecker
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Patent number: 4046913Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is alkyl of 6 to 19 carbon atoms, andR.sub.2 is methyl or ethyl,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as the salts are useful as pharmaceuticals for the treatment of cardiac and circulatory insufficiencies.Type: GrantFiled: February 23, 1976Date of Patent: September 6, 1977Assignee: Boehringer Ingelheim GmbHInventors: Anton Mentrup, Kurt Schromm, Ernst-Otto Renth, Werner Traunecker
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Patent number: 4038314Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen or methyl, and R.sub.2 is phenoxy-(alkyl of 2 to 3 carbon atoms), phenyl-(alkyl of 4 to 5 carbon atoms), hydroxyphenyl-(alkyl of 3 to 5 carbon atoms), or naphthyl-(alkyl of 4 to 5 carbon atoms);And their non-toxic, pharmacologically acceptable acid additions salts; the compounds as well as the salts are useful as dilators of the peripheral blood vessels, as cardiotonics and as broncholytics.Type: GrantFiled: March 21, 1974Date of Patent: July 26, 1977Assignee: Boehringer Ingelheim GmbHInventors: Anton Mentrup, Kurt Schromm, Ernst-Otto Renth, Werner Traunecker
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Patent number: 4031212Abstract: The compound of the formula ##STR1## which is useful as a cardiotonic.Type: GrantFiled: July 30, 1975Date of Patent: June 21, 1977Assignee: Boehringer Ingelheim GmbHInventors: Walter Losel, Werner Traunecker, Wolfgang Hoefke
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Patent number: 4025646Abstract: Pharmaceutical compositions containing as an active ingredient a racemic or optically active compound of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy of 1 to 4 carbon atoms, andR.sub.2 is straight or branched hydroxyalkyl of 3 to 6 carbon atoms,Or a non-toxic, pharmacologically acceptable acid addition salt thereof; and a method of using the same as .beta.-adrenergic receptor blocking agents and hypotensives.Type: GrantFiled: January 26, 1976Date of Patent: May 24, 1977Assignee: Boehringer Ingelheim GmbHInventors: Herbert Koppe, Helmut Stahle, Werner Kummer, Werner Traunecker
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Patent number: 4021547Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are hydrogen or carboxylic acyl, particularly acetyl, benzoyl or p-nitro-benzoyl; the compounds are useful as cardiotonics.Type: GrantFiled: January 21, 1976Date of Patent: May 3, 1977Assignee: Boehringer Ingelheim GmbHInventors: Walter Losel, Werner Traunecker, Wolfgang Hoefke
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Patent number: 4021485Abstract: Compounds of the formula ##STR1## WHEREIN R.sub.1 is hydrogen or methyl,m is 0 or an integer from 1 to 8, inclusive, andAr is ##STR2## WHERE R is hydrogen or acyl, andR.sub.2 is hydrogen or --OR, as defined above, ##STR3## WHERE R has the meanings defined above, andR.sub.3 is hydroxy-lower alkyl, --NH--CO--R.sub.4, --NH--SO.sub.2 --R.sub.5, --CH.sub.2 --NH--CO--R.sub.4, --CH.sub.2 --NH--SO.sub.2 --R.sub.5 or --CH.sub.2 --NH--CO--NH--R.sub.4,whereR.sub.4 is hydrogen or lower alkyl, andR.sub.5 is lower alkyl or di-lower alkyl-amino, ##STR4## WHERE R.sub.6 is hydrogen, amino or hydroxyl,X is chlorine or bromine, andY is hydrogen, chlorine or bromineor ##STR5## WHERE R has the meanings defined above, andA is a saturated or unsaturated 5- to 6-membered ring,And their non-toxic, pharmacologically acceptable acid addition salts; the compounds as well as their salts are useful as bronchospasmolytics, uterine spasmolytics, antipruritics and antiallergics.Type: GrantFiled: November 4, 1975Date of Patent: May 3, 1977Assignee: Boehringer Ingelheim GmbHInventors: Kurt Schromm, Anton Mentrup, Ernst-Otto Renth, Werner Traunecker
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Patent number: 4015011Abstract: Compounds of the formula ##STR1## wherein R.sub.1 is hydrogen, --(CH.sub.2).sub.n --R.sub.4 or --CO--R.sub.5, wheren is 1 or 2,R.sub.4 is hydrogen, cyano or benzoyl, andR.sub.5 is hydrogen, lower alkoxy, benzyloxy, --CH.sub.2 --NH.sub.2, --CH(CH.sub.3)--NH.sub.2, --CH.sub.2 --NH--CH.sub.2 --C.sub.6 H.sub.5 or --CH(CH.sub.3)--NH--CH.sub.2 --C.sub.6 H.sub.5,R.sub.2 is hydrogen or methyl, andR.sub.3 is amino, nitro, --NH--CO--R.sub.6 or --NH--A--R.sub.7, whereR.sub.6 is hydrogen, methyl, methoxy, ethoxy, methylthio or ethylthio,R.sub.7 is amino, methylamino or dimethylamino, andA is --CO-- or --SO.sub.2 --,and non-toxic, pharmacologically acceptable acid addition salts thereof; the compounds as well as their salts are useful as hypertensives.Type: GrantFiled: April 25, 1975Date of Patent: March 29, 1977Assignee: Boehringer Ingelheim GmbHInventors: Kurt Schromm, Anton Mentrup, Ernst Otto Renth, Ludwig Pichler, Werner Traunecker