Patents by Inventor Werner Tueckmantel

Werner Tueckmantel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthesis of 4&agr;-arylepicatechins
    Patent number: 6476241
    Abstract: Oligomeric procyanidins containing 4&agr;-linked epicatechin units are rare in nature and have hitherto not been accessible through stereoselective synthesis. Provided herein is the preparation of the prototypical dimer, epicatechin-4&agr;,8-epicatechin, by reaction of the protected 4-ketones with aryllithium reagents derived by halogen/metal exchange from the aryl bromides. Removal of the 4-hydroxyl group from the resulting tertiary benzylic alcohols is effected by tri-n-butyltin hydride and trifluoroacetic acid in a completely stereoselective manner, resulting in hydride delivery exclusively from the &bgr; face.
    Type: Grant
    Filed: September 5, 2000
    Date of Patent: November 5, 2002
    Assignee: Mars Incorporated
    Inventors: Alan P. Kozikowski, Leo J. Romanczyk, Jr., Werner Tückmantel
  • Synthetic methods for polyphenols
    Publication number: 20020128493
    Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.
    Type: Application
    Filed: December 14, 2001
    Publication date: September 12, 2002
    Applicant: Mars, Incorporated
    Inventors: Leo J. Romanczyk, Alan P. Kozikowski, Werner Tueckmantel, Marc E. Lippman
  • Synthetic methods for preparation of protected proanthocyanidin(s)
    Patent number: 6420572
    Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomeric units, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomeric units. Advantageously, polyphenol monomeric units forming the polyphenol oligomers may be the same or different flavanoid compounds.
    Type: Grant
    Filed: October 9, 1998
    Date of Patent: July 16, 2002
    Assignee: Mars, Incorporated
    Inventors: Leo J. Romanczyk, Jr., Alan P. Kozikowski, Werner Tueckmantel, Marc E. Lippman
  • Bicyclic metabotropic glutamate receptor ligands
    Patent number: 6376532
    Abstract: The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.
    Type: Grant
    Filed: January 25, 2001
    Date of Patent: April 23, 2002
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Darryl Hugh Steensma, Werner Tueckmantel, Gian Luca Araldi
  • Bicyclic metabotropic glutamate receptor ligands
    Publication number: 20010018429
    Abstract: The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.
    Type: Application
    Filed: January 25, 2001
    Publication date: August 30, 2001
    Inventors: Alan P. Kozikowski, Darryl Hugh Steensma, Werner Tueckmantel, Gian Luca Araldi
  • Intermediates useful for the synthesis of huperzine A
    Patent number: 6271379
    Abstract: Intermediates useful for the synthesis of huperzine A represented by the structures below, and methods for their synthesis, wherein: R1 is lower alkyl, benzyl, or substituted benzyl; X is a suitable leaving group; Y is an electron withdrawing group that can subsequently be converted into an amino group; one broken line is present as a carbon—carbon bond and the other broken line is absent, where the broken line forms an unconjugated carbon—carbon double bond, which double bond may be endocyclic whereby n is 3 or the double bond may be exocyclic whereby n is 2.
    Type: Grant
    Filed: March 8, 2000
    Date of Patent: August 7, 2001
    Assignee: Georgetown University
    Inventors: Werner Tückmantel, Alan P. Kozikowski
  • Process for preparing procyanidin(4-6 or 4-8) oligomers and their derivatives
    Patent number: 6207842
    Abstract: A process is disclosed for the production of polyphenol oligomers having n polyphenol monomers, n being an integer from 2-18. The process includes coupling of a protected polyphenol, having protected phenolic hydroxyl groups, with a C-4 functionalized polyphenol monomer. The protected polyphenol may be a protected polyphenol monomer or a protected polyphenol oligomer having 2-17 monomers. Advantageously, polyphenol monomers forming the polyphenol oligomers may be the same or different.
    Type: Grant
    Filed: October 9, 1997
    Date of Patent: March 27, 2001
    Assignee: Mars Incorporated
    Inventors: Leo J. Romanczyk, Jr., Alan P. Kozikowski, Werner Tueckmantel
  • Bicyclic metabotropic glutamate receptor ligands
    Patent number: 6204292
    Abstract: The present invention provides bicyclic metabotropic glutamate receptor ligands, as well as compositions comprising such ligands, and and methods for their use.
    Type: Grant
    Filed: July 17, 1998
    Date of Patent: March 20, 2001
    Assignee: Georgetown University
    Inventors: Alan P. Kozikowski, Darryl Hugh Steensma, Werner Tueckmantel, Gian Luca Araldi