Abstract: Methods, devices, and systems for performing isoelectric focusing reactions are described. The systems or devices disclosed herein may comprise fixtures that have a membrane. In some instances, the disclosed devices may be designed to perform isoelectric focusing or other separation reactions followed by further characterization of the separated analytes using mass spectrometry. Two or more isoelectric focusing reactions may be performed in parallel. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.

Abstract: Disclosed and described herein is a cartridge assembly with a fluidic device and harness and method of use.

Abstract: A method of forming a master mold (52), comprising: a) forming a plurality of microstructure portions (42) in a substrate formed of a first material by a first micromachining process, each microstructure portion comprising a shaft (40) and a distal tip (38); b) preparing a negative mold (46) of the plurality of microstructure portions, wherein the mold is formed of a second material and comprises a plurality of cavities (48) corresponding to each microstructure portion in the plurality of microstructure portions (42); c) electroplating a metal (50) onto the negative mold to fill each cavity in the plurality of cavities and to form a base layer (54) extending from the negative mold; d) forming a proximal section (56) for each of the microstructures in the base layer using a second micromachining process (e.g. mechanical micromachining); and e) before or after said step d), removing the negative mold from the metal to form a master mold.

Abstract: An optical driving assembly includes an optical element having an optical axis, an optical sensor, and a driving module driving optical sensor to translate along a direction perpendicular to the optical axis. The driving module includes a fixation member provided with a moving cavity, a moving member provided in the first moving cavity and movably connected to the fixation member along a first direction and provided with a second moving cavity, a supporting member provided in the second moving cavity and movably connected to the moving member along a second direction and supporting the optical sensor, and first and second driving assemblies. The first and second driving assemblies include first and second shape memory alloy wires. The optical sensor can linearly move in two directions perpendicular to the optical axis, achieving optical image stabilization and independent movements in two directions that are not affected by each other.

Abstract: Methods, devices, and systems for performing isoelectric focusing reactions are described. The systems or devices disclosed herein may comprise fixtures that have a membrane. In some instances, the disclosed devices may be designed to perform isoelectric focusing or other separation reactions followed by further characterization of the separated analytes using mass spectrometry. Two or more isoelectric focusing reactions may be performed in parallel. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.

Abstract: Methods, devices, and systems for performing nebulization of a sample from a fluid channel of a microfluidic device are described. The systems or devices disclosed herein may comprise microfluidic devices that comprise a gas channel used for nebulization of the sample at a fluid outlet of the microfluidic device. In some instances, the disclosed devices may be designed to perform isoelectric focusing followed by further characterization of the separated analytes using electrospray ionization coupled with nebulization to introduce the samples into a mass spectrometer. The disclosed methods, devices, and systems provide for fast, accurate separation and characterization of protein analyte mixtures or other biological molecules by isoelectric point.

Abstract: An optical driving assembly includes an optical element having an optical axis, an optical sensor, and a driving module driving optical sensor to translate along a direction perpendicular to the optical axis. The driving module includes a fixation member provided with a moving cavity, a moving member provided in the first moving cavity and movably connected to the fixation member along a first direction and provided with a second moving cavity, a supporting member provided in the second moving cavity and movably connected to the moving member along a second direction and supporting the optical sensor, and first and second driving assemblies. The first and second driving assemblies include first and second shape memory alloy wires. The optical sensor can linearly move in two directions perpendicular to the optical axis, achieving optical image stabilization and independent movements in two directions that are not affected by each other.

Abstract: An actuation device and a camera device are provided. The actuation device includes a fixation base including a first bottom plate, a rotation base including a second bottom plate, a spindle assembly between the first bottom plate and the second bottom plate, a driving mechanism including two SMA wires connected to two suspension portions in a one-to-one correspondence, and a PCB connected to the driving mechanism. A first avoiding opening is provided on the first bottom plate. The two suspension portions extending toward the first avoiding opening is provided on the second bottom plate. Each SMA wire is connected to one suspension portion and a side of the first bottom plate. Two shape memory alloy wires drive the rotation base to rotate counterclockwise and clockwise around the central axis, respectively. The SMA wires can control the rotation base to rotate around the optical axis of the camera lens.

Abstract: A method of forming a master mold (52), comprising: a) forming a plurality of microstructure portions (42) in a substrate formed of a first material by a first micromachining process, each microstructure portion comprising a shaft (40) and a distal tip (38); b) in preparing a negative mold (46) of the plurality of microstructure portions, wherein the mold is formed of a second material and comprises a plurality of cavities (48) corresponding to each microstructure portion in the plurality of microstructure portions (42); c) electroplating a metal (50) onto the negative mold to fill each cavity in the plurality of cavities and to form abase layer (54) extending from the negative mold; d) forming a proximal section (56) for each of the microstructures in the base layer using a second micromachining process (e.g. mechanical micromachining); and e) before or after said step d), removing the negative mold from the metal to form a master mold.

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: A shoveling and throwing device for moving a material, such as snow, from a surface.

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

Abstract: The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.