Abstract: The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.

Abstract: The present invention provides compositions and methods for delaying or preventing progression to type 2 diabetes mellitus in individuals with prediabetes and metabolic syndrome.

Abstract: A multiuse programmable dental device that allows the user to selectively program various fluid delivery regimens and methods of using and programming the irrigator device. The irrigator may also be operated manually, as desired by the operator. Other features, such as selective delivery of various fluids, monitoring fluids levels of the system, and the capability to store previously used regimens within the systems memory, are found in the present invention.

Abstract: The present invention relates to fusion proteins comprising an insulin receptor agonist fused to a human IgG Fc region through the use of a peptide linker, and the use of such fusion proteins in the treatment of diabetes. The fusion protein of the present invention has an extended time action profile and is useful for providing basal glucose control for an extended period of time.

Abstract: The present invention provides compositions and methods for delaying or preventing progression to type 2 diabetes mellitus in individuals with prediabetes and metabolic syndrome.

Abstract: A multiuse programmable dental device that allows the user to selectively program various fluid delivery regimens and methods of using and programming the irrigator device. The irrigator may also be operated manually, as desired by the operator. Other features, such as selective delivery of various fluids, monitoring fluids levels of the system, and the capability to store previously used regimens within the systems memory, are found in the present invention.

Abstract: A multiuse programmable dental device that allows the user to selectively program various fluid delivery regimens and methods of using and programming the irrigator device. The irrigator may also be operated manually, as desired by the operator. Other features, such as selective delivery of various fluids, monitoring fluids levels of the system, and the capability to store previously used regimens within the systems memory, are found in the present invention.

Abstract: This invention relates to methods and kits useful for improving or maintaining urogenital health using an estrogen agonist/antagonist. The methods of treatment are effective for improving or maintaining urogenital health while substantially reducing the concomitant liability of adverse effects associated with estrogen administration. This invention also relates to methods of assessing vaginal health.

Abstract: The present invention provides methods and kits for treating depression, perimenopausal depression, schizophrenia, anxiety, panic attacks, binge eating, social phobia, or preventing deterioration of cognitive function by administering to a patient in need thereof a therapeutically effect amount of an estrogen agonist/antagonist of formula I

Abstract: A bolt support member for use in cutting lock bolts of security containers. The bolt support member has a hook-shaped portion at one end for engaging a lock bolt, and threaded portion at another end. The hook-shaped portion is inserted into a hole in the container near the lock bolt and is clamped between the lock bolt and the surface of the container by a pair of knobs positioned on the threaded portion of the bolt support member. The bolt support member constrains the lock bolt from bending under cutting pressure and thus prevents binding against the cutter.