Abstract: Described herein are assays and methods to detect and/or treat a non-responsive or treatment resistant p16 positive tumor in a subject in need thereof. The disclosed method can also involve determining if the subject is HPV positive or negative, whether the HPV is integrated or episomal, and selecting a suitable treatment based on these determinations. Also disclosed herein is a method of treating an oropharyngeal squamous cell carcinoma in a subject using the arrays and methods disclosed herein.

Abstract: Mobile terminals include a portable housing and a wireless communication network interface circuit in the housing. A memory is coupled to the housing and a user interface is in the housing. A data interface in the housing is configured to be operatively coupled to a game module and a controller in the housing is configured to couple the memory and/or the user interface of the mobile terminal to the game module through the data interface to supplement resources of the game module using the memory and/or the user interface. Methods and computer program products are also provided.

Abstract: A low pressure, self-contained fire suppression system comprising a source of pressurized gas, a water reservoir tank containing water, a foam concentrate tank containing foam concentrate, and a water driven volumetric metering pump. The source of gas under pressure communicates with the water reservoir tank to provide a source of water under pressure. A conduit communicates the pressurized water tank with a first inlet port of the metering pump. The foam concentrate tank communicates with the metering pump via a second inlet port. Concentrate is supplied to the metering pump at a predetermined volumetric flow rate in response to water flowing through the metering pump. The source of pressurized gas also communicates via a conduit with the outlet port of said metering pump to thereby introduce gas under pressure to the water/foam concentrate mixture as it exits the metering pump. The water, foam concentrate and gas mixture is passed through a conduit, such as a hose, wherein a foam is generated.